CompaRNA - on-line benchmarks of RNA structure prediction methods

FAQ

Metric	Murlet(seed)		Multilign(20)
MCC	0.439	>	0.380
Average MCC ± 95% Confidence Intervals	0.443 ± 0.115	>	0.387 ± 0.200
Sensitivity	0.234	<	0.317
Positive Predictive Value	0.829	>	0.462
Total TP	68	<	92
Total TN	48033	>	47916
Total FP	17	<	124
Total FP CONTRA	1	<	14
Total FP INCONS	13	<	93
Total FP COMP	3	<	17
Total FN	222	>	198
P-value	0.0

Comparison of performance of Murlet(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and Multilign(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and Multilign(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and Multilign(20)).

Total Scores
MCC	0.439
Average MCC ± 95% Confidence Intervals	0.443 ± 0.115
Sensitivity	0.234
Positive Predictive Value	0.829
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
3J3E_8	5_8S_rRNA links to Rfam database...	0.25	0.06	1.00	2	7501	2	0	0	2	31
3J3F_8	5_8S_rRNA links to Rfam database...	0.44	0.19	1.00	7	12239	0	0	0	0	29
3RKF_A	Purine links to Rfam database...	0.53	0.35	0.80	12	2196	3	1	2	0	22
3SD1_A	THF links to Rfam database...	0.47	0.26	0.85	11	3903	2	0	2	0	31
4A1C_2	5_8S_rRNA links to Rfam database...	0.46	0.21	1.00	7	11774	0	0	0	0	26
4AOB_A	SAM links to Rfam database...	0.58	0.33	1.00	14	4357	1	0	0	1	28
4ENB_A	crcB links to Rfam database...	0.56	0.32	1.00	6	1269	0	0	0	0	13
4ENC_A	crcB links to Rfam database...	0.56	0.32	1.00	6	1320	0	0	0	0	13
4FRG_B	AdoCbl-variant links to Rfam database...	0.15	0.09	0.25	3	3474	9	0	9	0	29

Total Scores
MCC	0.380
Average MCC ± 95% Confidence Intervals	0.387 ± 0.200
Sensitivity	0.317
Positive Predictive Value	0.462
Nr of predictions	9

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
3J3E_8	5_8S_rRNA links to Rfam database...	0.00	0.00	0.00	0	7481	22	6	16	0	33
3J3F_8	5_8S_rRNA links to Rfam database...	0.41	0.36	0.46	13	12218	27	1	14	12	23
3RKF_A	Purine links to Rfam database...	0.77	0.62	0.95	21	2189	1	0	1	0	13
3SD1_A	THF links to Rfam database...	0.57	0.48	0.69	20	3887	9	1	8	0	22
4A1C_2	5_8S_rRNA links to Rfam database...	0.15	0.15	0.15	5	11747	33	3	26	4	28
4AOB_A	SAM links to Rfam database...	0.49	0.38	0.64	16	4346	10	1	8	1	26
4ENB_A	crcB links to Rfam database...	0.34	0.26	0.45	5	1264	6	1	5	0	14
4ENC_A	crcB links to Rfam database...	0.65	0.47	0.90	9	1316	1	1	0	0	10
4FRG_B	AdoCbl-variant links to Rfam database...	0.12	0.09	0.17	3	3468	15	0	15	0	29

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.