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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & Afold [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) Afold
MCC 0.526 > 0.416
Average MCC ± 95% Confidence Intervals 0.484 ± 0.443 > 0.426 ± 0.499
Sensitivity 0.410 > 0.381
Positive Predictive Value 0.679 > 0.459
Total TP 55 > 51
Total TN 27499 > 27469
Total FP 40 < 82
Total FP CONTRA 0 < 8
Total FP INCONS 26 < 52
Total FP COMP 14 < 22
Total FN 79 < 83
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Afold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Afold).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 55
Total TN 27499
Total FP 40
Total FP CONTRA 0
Total FP INCONS 26
Total FP COMP 14
Total FN 79
Total Scores
MCC 0.526
Average MCC ± 95% Confidence Intervals 0.484 ± 0.443
Sensitivity 0.410
Positive Predictive Value 0.679
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.32 0.21 0.50 7 7489 11 0 7 4 26
3ZEX_D 0.81 0.71 0.92 35 6983 3 0 3 0 14
4A1C_2 0.19 0.15 0.25 5 11761 25 0 15 10 28
4ENB_A 0.61 0.42 0.89 8 1266 1 0 1 0 11

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 51
Total TN 27469
Total FP 82
Total FP CONTRA 8
Total FP INCONS 52
Total FP COMP 22
Total FN 83
Total Scores
MCC 0.416
Average MCC ± 95% Confidence Intervals 0.426 ± 0.499
Sensitivity 0.381
Positive Predictive Value 0.459
Nr of predictions 4

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.17 0.15 0.19 5 7477 31 2 19 10 28
3ZEX_D 0.72 0.61 0.86 30 6986 5 0 5 0 19
4A1C_2 0.14 0.15 0.14 5 11745 43 5 26 12 28
4ENB_A 0.67 0.58 0.79 11 1261 3 1 2 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.