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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) Mastr(seed)
MCC 0.649 > 0.000
Average MCC ± 95% Confidence Intervals 0.630 ± 0.114 > 0.000 ± 0.000
Sensitivity 0.530 > 0.000
Positive Predictive Value 0.798 > 0.000
Total TP 364 > 0
Total TN 110739 < 111195
Total FP 120 > 0
Total FP CONTRA 4 > 0
Total FP INCONS 88 > 0
Total FP COMP 28 > 0
Total FN 323 < 687
P-value 2.39162260866e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Mastr(seed)).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 364
Total TN 110739
Total FP 120
Total FP CONTRA 4
Total FP INCONS 88
Total FP COMP 28
Total FN 323
Total Scores
MCC 0.649
Average MCC ± 95% Confidence Intervals 0.630 ± 0.114
Sensitivity 0.530
Positive Predictive Value 0.798
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J20_0 0.84 0.70 1.00 21 2829 0 0 0 0 9
3J2L_3 0.78 0.62 0.97 33 7841 3 0 1 2 20
3J3D_C 0.80 0.68 0.95 19 2755 1 0 1 0 9
3J3E_8 0.32 0.21 0.50 7 7489 11 0 7 4 26
3J3E_7 0.74 0.63 0.87 34 7101 5 1 4 0 20
3J3F_7 0.78 0.68 0.89 34 7222 5 1 3 1 16
3J3F_8 0.30 0.25 0.38 9 12222 22 0 15 7 27
3J3V_B 0.65 0.51 0.83 29 6986 6 1 5 0 28
3ZEX_D 0.81 0.71 0.92 35 6983 3 0 3 0 14
3ZEX_C 0.24 0.17 0.35 9 14170 18 0 17 1 43
3ZND_W 0.47 0.43 0.53 10 2984 11 0 9 2 13
4A1C_2 0.19 0.15 0.25 5 11761 25 0 15 10 28
4A1C_3 0.82 0.69 0.97 37 7102 1 0 1 0 17
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENB_A 0.61 0.42 0.89 8 1266 1 0 1 0 11
4ENC_A 0.55 0.42 0.73 8 1315 3 0 3 0 11
4FRG_B 0.75 0.63 0.91 20 3464 2 1 1 0 12

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 111195
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 687
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 18

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.00 0.00 0.00 0 2926 0 0 0 0 23
3J20_0 0.00 0.00 0.00 0 2850 0 0 0 0 30
3J2L_3 0.00 0.00 0.00 0 7875 0 0 0 0 53
3J3D_C 0.00 0.00 0.00 0 2775 0 0 0 0 28
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3E_7 0.00 0.00 0.00 0 7140 0 0 0 0 54
3J3F_7 0.00 0.00 0.00 0 7260 0 0 0 0 50
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3J3V_B 0.00 0.00 0.00 0 7021 0 0 0 0 57
3ZEX_D 0.00 0.00 0.00 0 7021 0 0 0 0 49
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
3ZND_W 0.00 0.00 0.00 0 3003 0 0 0 0 23
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.