CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	PPfold(20)		HotKnots
MCC	0.663	>	0.497
Average MCC ± 95% Confidence Intervals	0.642 ± 0.107	>	0.514 ± 0.128
Sensitivity	0.528	>	0.443
Positive Predictive Value	0.836	>	0.564
Total TP	387	>	325
Total TN	112841	>	112728
Total FP	98	<	295
Total FP CONTRA	0	<	25
Total FP INCONS	76	<	226
Total FP COMP	22	<	44
Total FN	346	<	408
P-value	5.1503931209e-08

Comparison of performance of PPfold(20) and HotKnots. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and HotKnots).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(20) and HotKnots).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and HotKnots. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and HotKnots).

Total Scores
MCC	0.663
Average MCC ± 95% Confidence Intervals	0.642 ± 0.107
Sensitivity	0.528
Positive Predictive Value	0.836
Nr of predictions	20

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
3AMU_B	tRNA links to Rfam database...	0.86	0.74	1.00	20	2983	1	0	0	1	7
3J20_0	tRNA links to Rfam database...	0.84	0.70	1.00	21	2829	0	0	0	0	9
3J20_1	tRNA links to Rfam database...	0.96	0.91	1.00	21	2905	0	0	0	0	2
3J2L_3	5S_rRNA links to Rfam database...	0.78	0.62	0.97	33	7841	3	0	1	2	20
3J3D_C	tRNA links to Rfam database...	0.80	0.68	0.95	19	2755	1	0	1	0	9
3J3E_7	5S_rRNA links to Rfam database...	0.74	0.61	0.89	33	7103	4	0	4	0	21
3J3E_8	5_8S_rRNA links to Rfam database...	0.14	0.09	0.23	3	7490	13	0	10	3	30
3J3F_7	5S_rRNA links to Rfam database...	0.80	0.68	0.94	34	7224	3	0	2	1	16
3J3F_8	5_8S_rRNA links to Rfam database...	0.33	0.25	0.43	9	12225	18	0	12	6	27
3RKF_A	Purine links to Rfam database...	0.73	0.56	0.95	19	2191	1	0	1	0	15
3SD1_A	THF links to Rfam database...	0.68	0.52	0.88	22	3891	3	0	3	0	20
3ZEX_D	5S_rRNA links to Rfam database...	0.81	0.71	0.92	35	6983	3	0	3	0	14
3ZEX_C	5_8S_rRNA links to Rfam database...	0.33	0.21	0.52	11	14175	12	0	10	2	41
3ZND_W	tRNA links to Rfam database...	0.47	0.43	0.53	10	2984	11	0	9	2	13
4A1C_3	5S_rRNA links to Rfam database...	0.77	0.63	0.94	34	7104	2	0	2	0	20
4A1C_2	5_8S_rRNA links to Rfam database...	0.21	0.15	0.29	5	11764	16	0	12	4	28
4AOB_A	SAM links to Rfam database...	0.74	0.60	0.93	25	4344	3	0	2	1	17
4ENB_A	crcB links to Rfam database...	0.56	0.37	0.88	7	1267	1	0	1	0	12
4ENC_A	crcB links to Rfam database...	0.58	0.42	0.80	8	1316	2	0	2	0	11
4FRG_B	AdoCbl-variant links to Rfam database...	0.73	0.56	0.95	18	3467	1	0	1	0	14

Total Scores
MCC	0.497
Average MCC ± 95% Confidence Intervals	0.514 ± 0.128
Sensitivity	0.443
Positive Predictive Value	0.564
Nr of predictions	20

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
3AMU_B	tRNA links to Rfam database...	0.70	0.59	0.84	16	2984	5	0	3	2	11
3J20_0	tRNA links to Rfam database...	0.45	0.40	0.52	12	2827	12	0	11	1	18
3J20_1	tRNA links to Rfam database...	0.73	0.70	0.76	16	2905	7	0	5	2	7
3J2L_3	5S_rRNA links to Rfam database...	0.62	0.53	0.74	28	7837	12	0	10	2	25
3J3D_C	tRNA links to Rfam database...	0.28	0.25	0.32	7	2753	15	1	14	0	21
3J3E_7	5S_rRNA links to Rfam database...	0.59	0.50	0.71	27	7102	11	1	10	0	27
3J3E_8	5_8S_rRNA links to Rfam database...	0.10	0.09	0.11	3	7476	33	2	22	9	30
3J3F_7	5S_rRNA links to Rfam database...	0.73	0.64	0.84	32	7222	7	0	6	1	18
3J3F_8	5_8S_rRNA links to Rfam database...	0.30	0.31	0.30	11	12209	40	3	23	14	25
3RKF_A	Purine links to Rfam database...	0.76	0.59	1.00	20	2191	0	0	0	0	14
3SD1_A	THF links to Rfam database...	0.64	0.52	0.79	22	3888	6	1	5	0	20
3ZEX_D	5S_rRNA links to Rfam database...	0.78	0.67	0.92	33	6985	3	0	3	0	16
3ZEX_C	5_8S_rRNA links to Rfam database...	0.00	0.00	0.00	0	14150	46	6	40	0	52
3ZND_W	tRNA links to Rfam database...	0.20	0.22	0.19	5	2977	22	1	20	1	18
4A1C_3	5S_rRNA links to Rfam database...	0.70	0.59	0.82	32	7101	7	1	6	0	22
4A1C_2	5_8S_rRNA links to Rfam database...	0.14	0.15	0.14	5	11745	42	6	25	11	28
4AOB_A	SAM links to Rfam database...	0.50	0.40	0.63	17	4344	11	2	8	1	25
4ENB_A	crcB links to Rfam database...	0.89	0.79	1.00	15	1260	0	0	0	0	4
4ENC_A	crcB links to Rfam database...	0.86	0.79	0.94	15	1310	1	1	0	0	4
4FRG_B	AdoCbl-variant links to Rfam database...	0.32	0.28	0.38	9	3462	15	0	15	0	23

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.