CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric PPfold(20) Mastr(seed)
MCC 0.663 > 0.000
Average MCC ± 95% Confidence Intervals 0.642 ± 0.107 > 0.000 ± 0.000
Sensitivity 0.528 > 0.000
Positive Predictive Value 0.836 > 0.000
Total TP 387 > 0
Total TN 112841 < 113304
Total FP 98 > 0
Total FP CONTRA 0 = 0
Total FP INCONS 76 > 0
Total FP COMP 22 > 0
Total FN 346 < 733
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of PPfold(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(20) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Mastr(seed)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 387
Total TN 112841
Total FP 98
Total FP CONTRA 0
Total FP INCONS 76
Total FP COMP 22
Total FN 346
Total Scores
MCC 0.663
Average MCC ± 95% Confidence Intervals 0.642 ± 0.107
Sensitivity 0.528
Positive Predictive Value 0.836
Nr of predictions 20

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.86 0.74 1.00 20 2983 1 0 0 1 7
3J20_0 0.84 0.70 1.00 21 2829 0 0 0 0 9
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.78 0.62 0.97 33 7841 3 0 1 2 20
3J3D_C 0.80 0.68 0.95 19 2755 1 0 1 0 9
3J3E_7 0.74 0.61 0.89 33 7103 4 0 4 0 21
3J3E_8 0.14 0.09 0.23 3 7490 13 0 10 3 30
3J3F_7 0.80 0.68 0.94 34 7224 3 0 2 1 16
3J3F_8 0.33 0.25 0.43 9 12225 18 0 12 6 27
3RKF_A 0.73 0.56 0.95 19 2191 1 0 1 0 15
3SD1_A 0.68 0.52 0.88 22 3891 3 0 3 0 20
3ZEX_D 0.81 0.71 0.92 35 6983 3 0 3 0 14
3ZEX_C 0.33 0.21 0.52 11 14175 12 0 10 2 41
3ZND_W 0.47 0.43 0.53 10 2984 11 0 9 2 13
4A1C_3 0.77 0.63 0.94 34 7104 2 0 2 0 20
4A1C_2 0.21 0.15 0.29 5 11764 16 0 12 4 28
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENB_A 0.56 0.37 0.88 7 1267 1 0 1 0 12
4ENC_A 0.58 0.42 0.80 8 1316 2 0 2 0 11
4FRG_B 0.73 0.56 0.95 18 3467 1 0 1 0 14

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 113304
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 733
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 20

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.00 0.00 0.00 0 3003 0 0 0 0 27
3J20_0 0.00 0.00 0.00 0 2850 0 0 0 0 30
3J20_1 0.00 0.00 0.00 0 2926 0 0 0 0 23
3J2L_3 0.00 0.00 0.00 0 7875 0 0 0 0 53
3J3D_C 0.00 0.00 0.00 0 2775 0 0 0 0 28
3J3E_7 0.00 0.00 0.00 0 7140 0 0 0 0 54
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_7 0.00 0.00 0.00 0 7260 0 0 0 0 50
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3ZEX_D 0.00 0.00 0.00 0 7021 0 0 0 0 49
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
3ZND_W 0.00 0.00 0.00 0 3003 0 0 0 0 23
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.