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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric PPfold(20) Multilign(seed)
MCC 0.543 > 0.497
Average MCC ± 95% Confidence Intervals 0.523 ± 0.336 > 0.489 ± 0.300
Sensitivity 0.394 > 0.369
Positive Predictive Value 0.755 > 0.676
Total TP 80 > 75
Total TN 32091 > 32086
Total FP 32 < 37
Total FP CONTRA 0 < 9
Total FP INCONS 26 < 27
Total FP COMP 6 > 1
Total FN 123 < 128
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 80
Total TN 32091
Total FP 32
Total FP CONTRA 0
Total FP INCONS 26
Total FP COMP 6
Total FN 123
Total Scores
MCC 0.543
Average MCC ± 95% Confidence Intervals 0.523 ± 0.336
Sensitivity 0.394
Positive Predictive Value 0.755
Nr of predictions 5

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.14 0.09 0.23 3 7490 13 0 10 3 30
3RKF_A 0.73 0.56 0.95 19 2191 1 0 1 0 15
3SD1_A 0.68 0.52 0.88 22 3891 3 0 3 0 20
3ZEX_C 0.33 0.21 0.52 11 14175 12 0 10 2 41
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 32086
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.497
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300
Sensitivity 0.369
Positive Predictive Value 0.676
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.