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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of TurboFold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & TurboFold(20) [.zip] - may take several seconds...


Overview

Metric PPfold(20) TurboFold(20)
MCC 0.663 > 0.616
Average MCC ± 95% Confidence Intervals 0.642 ± 0.107 > 0.618 ± 0.099
Sensitivity 0.528 > 0.508
Positive Predictive Value 0.836 > 0.752
Total TP 387 > 372
Total TN 112841 > 112809
Total FP 98 < 168
Total FP CONTRA 0 < 11
Total FP INCONS 76 < 112
Total FP COMP 22 < 45
Total FN 346 < 361
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of PPfold(20) and TurboFold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and TurboFold(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(20) and TurboFold(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and TurboFold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and TurboFold(20)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 387
Total TN 112841
Total FP 98
Total FP CONTRA 0
Total FP INCONS 76
Total FP COMP 22
Total FN 346
Total Scores
MCC 0.663
Average MCC ± 95% Confidence Intervals 0.642 ± 0.107
Sensitivity 0.528
Positive Predictive Value 0.836
Nr of predictions 20

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.86 0.74 1.00 20 2983 1 0 0 1 7
3J20_0 0.84 0.70 1.00 21 2829 0 0 0 0 9
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.78 0.62 0.97 33 7841 3 0 1 2 20
3J3D_C 0.80 0.68 0.95 19 2755 1 0 1 0 9
3J3E_7 0.74 0.61 0.89 33 7103 4 0 4 0 21
3J3E_8 0.14 0.09 0.23 3 7490 13 0 10 3 30
3J3F_7 0.80 0.68 0.94 34 7224 3 0 2 1 16
3J3F_8 0.33 0.25 0.43 9 12225 18 0 12 6 27
3RKF_A 0.73 0.56 0.95 19 2191 1 0 1 0 15
3SD1_A 0.68 0.52 0.88 22 3891 3 0 3 0 20
3ZEX_D 0.81 0.71 0.92 35 6983 3 0 3 0 14
3ZEX_C 0.33 0.21 0.52 11 14175 12 0 10 2 41
3ZND_W 0.47 0.43 0.53 10 2984 11 0 9 2 13
4A1C_3 0.77 0.63 0.94 34 7104 2 0 2 0 20
4A1C_2 0.21 0.15 0.29 5 11764 16 0 12 4 28
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENB_A 0.56 0.37 0.88 7 1267 1 0 1 0 12
4ENC_A 0.58 0.42 0.80 8 1316 2 0 2 0 11
4FRG_B 0.73 0.56 0.95 18 3467 1 0 1 0 14

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Performance of TurboFold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 372
Total TN 112809
Total FP 168
Total FP CONTRA 11
Total FP INCONS 112
Total FP COMP 45
Total FN 361
Total Scores
MCC 0.616
Average MCC ± 95% Confidence Intervals 0.618 ± 0.099
Sensitivity 0.508
Positive Predictive Value 0.752
Nr of predictions 20

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3J20_0 0.66 0.57 0.77 17 2828 6 0 5 1 13
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.74 0.58 0.94 31 7842 5 0 2 3 22
3J3D_C 0.82 0.71 0.95 20 2754 1 0 1 0 8
3J3E_7 0.65 0.54 0.78 29 7103 8 1 7 0 25
3J3E_8 0.17 0.15 0.21 5 7479 28 2 17 9 28
3J3F_7 0.79 0.68 0.92 34 7223 4 0 3 1 16
3J3F_8 0.38 0.36 0.39 13 12213 34 2 18 14 23
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.59 0.48 0.74 20 3889 7 1 6 0 22
3ZEX_D 0.76 0.63 0.91 31 6987 3 0 3 0 18
3ZEX_C 0.39 0.27 0.56 14 14171 14 2 9 3 38
3ZND_W 0.43 0.39 0.47 9 2984 12 1 9 2 14
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A1C_2 0.18 0.15 0.21 5 11757 28 0 19 9 28
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.