CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(seed) - scored higher in this pairwise comparison

  4. Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(seed) & PETfold_pre2.0(20) [.zip] - may take several seconds...


Overview

Metric RNASampler(seed) PETfold_pre2.0(20)
MCC 0.299 > 0.262
Average MCC ± 95% Confidence Intervals 0.296 ± 0.207 > 0.266 ± 0.095
Sensitivity 0.214 > 0.195
Positive Predictive Value 0.423 > 0.357
Total TP 33 > 30
Total TN 45648 > 45642
Total FP 70 < 76
Total FP CONTRA 4 > 0
Total FP INCONS 41 < 54
Total FP COMP 25 > 22
Total FN 121 < 124
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(seed) and PETfold_pre2.0(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and PETfold_pre2.0(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and PETfold_pre2.0(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and PETfold_pre2.0(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and PETfold_pre2.0(20)).

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Performance of RNASampler(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 33
Total TN 45648
Total FP 70
Total FP CONTRA 4
Total FP INCONS 41
Total FP COMP 25
Total FN 121
Total Scores
MCC 0.299
Average MCC ± 95% Confidence Intervals 0.296 ± 0.207
Sensitivity 0.214
Positive Predictive Value 0.423
Nr of predictions 4

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.12 0.09 0.17 3 7485 22 2 13 7 30
3J3F_8 0.44 0.33 0.57 12 12225 15 1 8 6 24
3ZEX_C 0.32 0.19 0.53 10 14177 13 1 8 4 42
4A1C_2 0.31 0.24 0.40 8 11761 20 0 12 8 25

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Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 30
Total TN 45642
Total FP 76
Total FP CONTRA 0
Total FP INCONS 54
Total FP COMP 22
Total FN 124
Total Scores
MCC 0.262
Average MCC ± 95% Confidence Intervals 0.266 ± 0.095
Sensitivity 0.195
Positive Predictive Value 0.357
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.32 0.21 0.50 7 7489 11 0 7 4 26
3J3F_8 0.30 0.25 0.38 9 12222 22 0 15 7 27
3ZEX_C 0.24 0.17 0.35 9 14170 18 0 17 1 43
4A1C_2 0.19 0.15 0.25 5 11761 25 0 15 10 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.