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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(20) Multilign(seed)
MCC 0.556 > 0.497
Average MCC ± 95% Confidence Intervals 0.545 ± 0.277 > 0.489 ± 0.300
Sensitivity 0.409 > 0.369
Positive Predictive Value 0.761 > 0.676
Total TP 83 > 75
Total TN 32088 > 32086
Total FP 30 < 37
Total FP CONTRA 3 < 9
Total FP INCONS 23 < 27
Total FP COMP 4 > 1
Total FN 120 < 128
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Multilign(seed)).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 83
Total TN 32088
Total FP 30
Total FP CONTRA 3
Total FP INCONS 23
Total FP COMP 4
Total FN 120
Total Scores
MCC 0.556
Average MCC ± 95% Confidence Intervals 0.545 ± 0.277
Sensitivity 0.409
Positive Predictive Value 0.761
Nr of predictions 5

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.23 0.15 0.36 5 7489 9 1 8 0 28
3RKF_A 0.68 0.50 0.94 17 2193 1 0 1 0 17
3SD1_A 0.70 0.60 0.83 25 3886 5 1 4 0 17
3ZEX_C 0.39 0.27 0.56 14 14171 14 1 10 3 38
4AOB_A 0.72 0.52 1.00 22 4349 1 0 0 1 20

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 32086
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 128
Total Scores
MCC 0.497
Average MCC ± 95% Confidence Intervals 0.489 ± 0.300
Sensitivity 0.369
Positive Predictive Value 0.676
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.