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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Afold [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Afold
MCC 0.510 > 0.476
Average MCC ± 95% Confidence Intervals 0.512 ± 0.383 > 0.494 ± 0.386
Sensitivity 0.417 < 0.423
Positive Predictive Value 0.631 > 0.542
Total TP 70 < 71
Total TN 29680 > 29660
Total FP 59 < 82
Total FP CONTRA 2 < 8
Total FP INCONS 39 < 52
Total FP COMP 18 < 22
Total FN 98 > 97
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Afold).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 70
Total TN 29680
Total FP 59
Total FP CONTRA 2
Total FP INCONS 39
Total FP COMP 18
Total FN 98
Total Scores
MCC 0.510
Average MCC ± 95% Confidence Intervals 0.512 ± 0.383
Sensitivity 0.417
Positive Predictive Value 0.631
Nr of predictions 5

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.17 0.15 0.21 5 7479 28 2 17 9 28
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3ZEX_D 0.76 0.63 0.91 31 6987 3 0 3 0 18
4A1C_2 0.18 0.15 0.21 5 11757 28 0 19 9 28
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 71
Total TN 29660
Total FP 82
Total FP CONTRA 8
Total FP INCONS 52
Total FP COMP 22
Total FN 97
Total Scores
MCC 0.476
Average MCC ± 95% Confidence Intervals 0.494 ± 0.386
Sensitivity 0.423
Positive Predictive Value 0.542
Nr of predictions 5

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3E_8 0.17 0.15 0.19 5 7477 31 2 19 10 28
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3ZEX_D 0.72 0.61 0.86 30 6986 5 0 5 0 19
4A1C_2 0.14 0.15 0.14 5 11745 43 5 26 12 28
4ENB_A 0.67 0.58 0.79 11 1261 3 1 2 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.