CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	TurboFold(20)		Murlet(20)
MCC	0.616	>	0.580
Average MCC ± 95% Confidence Intervals	0.618 ± 0.099	>	0.561 ± 0.094
Sensitivity	0.508	>	0.439
Positive Predictive Value	0.752	<	0.772
Total TP	372	>	322
Total TN	112809	<	112887
Total FP	168	>	117
Total FP CONTRA	11	>	6
Total FP INCONS	112	>	89
Total FP COMP	45	>	22
Total FN	361	<	411
P-value	4.94031556815e-08

Comparison of performance of TurboFold(20) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Murlet(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for TurboFold(20) and Murlet(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Murlet(20)).

Total Scores
MCC	0.616
Average MCC ± 95% Confidence Intervals	0.618 ± 0.099
Sensitivity	0.508
Positive Predictive Value	0.752
Nr of predictions	20

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
3AMU_B	tRNA links to Rfam database...	0.70	0.59	0.84	16	2984	5	0	3	2	11
3J20_0	tRNA links to Rfam database...	0.66	0.57	0.77	17	2828	6	0	5	1	13
3J20_1	tRNA links to Rfam database...	0.96	0.91	1.00	21	2905	0	0	0	0	2
3J2L_3	5S_rRNA links to Rfam database...	0.74	0.58	0.94	31	7842	5	0	2	3	22
3J3D_C	tRNA links to Rfam database...	0.82	0.71	0.95	20	2754	1	0	1	0	8
3J3E_7	5S_rRNA links to Rfam database...	0.65	0.54	0.78	29	7103	8	1	7	0	25
3J3E_8	5_8S_rRNA links to Rfam database...	0.17	0.15	0.21	5	7479	28	2	17	9	28
3J3F_7	5S_rRNA links to Rfam database...	0.79	0.68	0.92	34	7223	4	0	3	1	16
3J3F_8	5_8S_rRNA links to Rfam database...	0.38	0.36	0.39	13	12213	34	2	18	14	23
3RKF_A	Purine links to Rfam database...	0.76	0.59	1.00	20	2191	0	0	0	0	14
3SD1_A	THF links to Rfam database...	0.59	0.48	0.74	20	3889	7	1	6	0	22
3ZEX_D	5S_rRNA links to Rfam database...	0.76	0.63	0.91	31	6987	3	0	3	0	18
3ZEX_C	5_8S_rRNA links to Rfam database...	0.39	0.27	0.56	14	14171	14	2	9	3	38
3ZND_W	tRNA links to Rfam database...	0.43	0.39	0.47	9	2984	12	1	9	2	14
4A1C_3	5S_rRNA links to Rfam database...	0.69	0.57	0.84	31	7103	6	0	6	0	23
4A1C_2	5_8S_rRNA links to Rfam database...	0.18	0.15	0.21	5	11757	28	0	19	9	28
4AOB_A	SAM links to Rfam database...	0.56	0.40	0.77	17	4349	6	1	4	1	25
4ENB_A	crcB links to Rfam database...	0.69	0.47	1.00	9	1266	0	0	0	0	10
4ENC_A	crcB links to Rfam database...	0.65	0.47	0.90	9	1316	1	1	0	0	10
4FRG_B	AdoCbl-variant links to Rfam database...	0.81	0.66	1.00	21	3465	0	0	0	0	11

Total Scores
MCC	0.580
Average MCC ± 95% Confidence Intervals	0.561 ± 0.094
Sensitivity	0.439
Positive Predictive Value	0.772
Nr of predictions	20

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
3AMU_B	tRNA links to Rfam database...	0.77	0.67	0.90	18	2983	3	0	2	1	9
3J20_0	tRNA links to Rfam database...	0.58	0.47	0.74	14	2831	5	0	5	0	16
3J20_1	tRNA links to Rfam database...	0.68	0.57	0.81	13	2910	3	0	3	0	10
3J2L_3	5S_rRNA links to Rfam database...	0.69	0.49	0.96	26	7848	3	0	1	2	27
3J3D_C	tRNA links to Rfam database...	0.78	0.64	0.95	18	2756	1	0	1	0	10
3J3E_7	5S_rRNA links to Rfam database...	0.77	0.63	0.94	34	7104	2	0	2	0	20
3J3E_8	5_8S_rRNA links to Rfam database...	0.24	0.15	0.38	5	7490	13	1	7	5	28
3J3F_7	5S_rRNA links to Rfam database...	0.69	0.50	0.96	25	7234	1	0	1	0	25
3J3F_8	5_8S_rRNA links to Rfam database...	0.48	0.36	0.65	13	12226	10	0	7	3	23
3RKF_A	Purine links to Rfam database...	0.68	0.47	1.00	16	2195	0	0	0	0	18
3SD1_A	THF links to Rfam database...	0.68	0.57	0.83	24	3887	5	1	4	0	18
3ZEX_D	5S_rRNA links to Rfam database...	0.77	0.65	0.91	32	6986	3	0	3	0	17
3ZEX_C	5_8S_rRNA links to Rfam database...	0.34	0.23	0.50	12	14172	15	1	11	3	40
3ZND_W	tRNA links to Rfam database...	0.45	0.39	0.53	9	2986	11	0	8	3	14
4A1C_3	5S_rRNA links to Rfam database...	0.59	0.41	0.85	22	7114	4	0	4	0	32
4A1C_2	5_8S_rRNA links to Rfam database...	0.17	0.15	0.20	5	11756	24	2	18	4	28
4AOB_A	SAM links to Rfam database...	0.72	0.55	0.96	23	4347	2	0	1	1	19
4ENB_A	crcB links to Rfam database...	0.46	0.21	1.00	4	1271	0	0	0	0	15
4ENC_A	crcB links to Rfam database...	0.51	0.26	1.00	5	1321	0	0	0	0	14
4FRG_B	AdoCbl-variant links to Rfam database...	0.17	0.13	0.25	4	3470	12	1	11	0	28

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.