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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(seed) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(seed) & RDfolder [.zip] - may take several seconds...


Overview

Metric TurboFold(seed) RDfolder
MCC 0.553 > 0.392
Average MCC ± 95% Confidence Intervals 0.539 ± 0.293 > 0.376 ± 0.263
Sensitivity 0.426 > 0.284
Positive Predictive Value 0.728 > 0.556
Total TP 75 > 50
Total TN 14536 < 14549
Total FP 29 < 41
Total FP CONTRA 5 > 3
Total FP INCONS 23 < 37
Total FP COMP 1 = 1
Total FN 101 < 126
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and RDfolder).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 75
Total TN 14536
Total FP 29
Total FP CONTRA 5
Total FP INCONS 23
Total FP COMP 1
Total FN 101
Total Scores
MCC 0.553
Average MCC ± 95% Confidence Intervals 0.539 ± 0.293
Sensitivity 0.426
Positive Predictive Value 0.728
Nr of predictions 6

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.59 0.48 0.74 20 3889 7 1 6 0 22
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 50
Total TN 14549
Total FP 41
Total FP CONTRA 3
Total FP INCONS 37
Total FP COMP 1
Total FN 126
Total Scores
MCC 0.392
Average MCC ± 95% Confidence Intervals 0.376 ± 0.263
Sensitivity 0.284
Positive Predictive Value 0.556
Nr of predictions 6

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1526 14 2 12 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.30 0.17 0.54 7 3903 6 0 6 0 35
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.43 0.32 0.60 6 1265 4 0 4 0 13
4ENC_A 0.43 0.32 0.60 6 1316 4 0 4 0 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.