CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold5 - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold5 & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold5 Carnac(seed)
MCC 0.456 > 0.188
Average MCC ± 95% Confidence Intervals 0.468 ± 0.123 > 0.084 ± 0.100
Sensitivity 0.391 > 0.036
Positive Predictive Value 0.539 < 1.000
Total TP 363 > 33
Total TN 147180 < 147820
Total FP 369 > 0
Total FP CONTRA 40 > 0
Total FP INCONS 270 > 0
Total FP COMP 59 > 0
Total FN 566 < 896
P-value 5.19332990918e-08

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Performance plots


  1. Comparison of performance of Vsfold5 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold5 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

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Performance of Vsfold5 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 363
Total TN 147180
Total FP 369
Total FP CONTRA 40
Total FP INCONS 270
Total FP COMP 59
Total FN 566
Total Scores
MCC 0.456
Average MCC ± 95% Confidence Intervals 0.468 ± 0.123
Sensitivity 0.391
Positive Predictive Value 0.539
Nr of predictions 26

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.90 0.82 1.00 9 397 0 0 0 0 2
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3GX2_A 0.51 0.40 0.67 16 4347 9 0 8 1 24
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3IZF_C 0.70 0.56 0.88 30 6869 4 0 4 0 24
3J3E_8 0.06 0.06 0.08 2 7477 31 5 19 7 31
3J3F_8 0.33 0.33 0.33 12 12210 35 5 19 11 24
3JYX_4 0.31 0.30 0.31 10 12214 32 3 19 10 23
3JYX_3 0.17 0.15 0.20 4 6308 18 4 12 2 23
3LA5_A -0.01 0.00 0.00 0 2469 16 0 16 0 34
3NPB_A 0.57 0.46 0.72 21 6992 9 1 7 1 25
3O58_2 0.45 0.42 0.48 16 7227 19 3 14 2 22
3O58_3 0.39 0.37 0.41 13 12371 28 7 12 9 22
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3RKF_A 0.75 0.65 0.88 22 2186 3 0 3 0 12
3SD1_A 0.11 0.10 0.15 4 3890 22 0 22 0 38
3W3S_B 0.76 0.70 0.82 28 4719 7 1 5 1 12
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.24 0.24 0.24 8 11748 37 3 22 12 25
4AOB_A 0.18 0.14 0.25 6 4347 19 1 17 1 36
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4FRN_A 0.13 0.11 0.17 4 5128 19 2 17 0 32
4JF2_A 0.84 0.77 0.92 24 2824 2 1 1 0 7

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 33
Total TN 147820
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 896
Total Scores
MCC 0.188
Average MCC ± 95% Confidence Intervals 0.084 ± 0.100
Sensitivity 0.036
Positive Predictive Value 1.000
Nr of predictions 26

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
3A3A_A 0.00 0.00 0.00 0 3655 0 0 0 0 37
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3J3E_8 0.00 0.00 0.00 0 7503 0 0 0 0 33
3J3F_8 0.00 0.00 0.00 0 12246 0 0 0 0 36
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36
4JF2_A 0.78 0.61 1.00 19 2831 0 0 0 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.