CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold5 - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold5 & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold5 Murlet(seed)
MCC 0.464 > 0.454
Average MCC ± 95% Confidence Intervals 0.481 ± 0.141 > 0.449 ± 0.070
Sensitivity 0.398 > 0.254
Positive Predictive Value 0.548 < 0.817
Total TP 301 > 192
Total TN 119673 < 119987
Total FP 303 > 50
Total FP CONTRA 31 > 6
Total FP INCONS 217 > 37
Total FP COMP 55 > 7
Total FN 455 < 564
P-value 0.011312336181

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Performance plots


  1. Comparison of performance of Vsfold5 and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold5 and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold5 and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold5 and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold5 and Murlet(seed)).

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Performance of Vsfold5 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 301
Total TN 119673
Total FP 303
Total FP CONTRA 31
Total FP INCONS 217
Total FP COMP 55
Total FN 455
Total Scores
MCC 0.464
Average MCC ± 95% Confidence Intervals 0.481 ± 0.141
Sensitivity 0.398
Positive Predictive Value 0.548
Nr of predictions 22

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.90 0.82 1.00 9 397 0 0 0 0 2
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3GX2_A 0.51 0.40 0.67 16 4347 9 0 8 1 24
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3J3E_8 0.06 0.06 0.08 2 7477 31 5 19 7 31
3J3F_8 0.33 0.33 0.33 12 12210 35 5 19 11 24
3JYX_4 0.31 0.30 0.31 10 12214 32 3 19 10 23
3LA5_A -0.01 0.00 0.00 0 2469 16 0 16 0 34
3NPB_A 0.57 0.46 0.72 21 6992 9 1 7 1 25
3O58_3 0.39 0.37 0.41 13 12371 28 7 12 9 22
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3RKF_A 0.75 0.65 0.88 22 2186 3 0 3 0 12
3SD1_A 0.11 0.10 0.15 4 3890 22 0 22 0 38
3W3S_B 0.76 0.70 0.82 28 4719 7 1 5 1 12
4A1C_2 0.24 0.24 0.24 8 11748 37 3 22 12 25
4AOB_A 0.18 0.14 0.25 6 4347 19 1 17 1 36
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4FRN_A 0.13 0.11 0.17 4 5128 19 2 17 0 32
4JF2_A 0.84 0.77 0.92 24 2824 2 1 1 0 7

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 192
Total TN 119987
Total FP 50
Total FP CONTRA 6
Total FP INCONS 37
Total FP COMP 7
Total FN 564
Total Scores
MCC 0.454
Average MCC ± 95% Confidence Intervals 0.449 ± 0.070
Sensitivity 0.254
Positive Predictive Value 0.817
Nr of predictions 22

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.52 0.27 1.00 3 403 0 0 0 0 8
2LC8_A -0.01 0.00 0.00 0 1528 12 0 12 0 20
3A3A_A 0.57 0.32 1.00 12 3643 0 0 0 0 25
3GX2_A 0.59 0.35 1.00 14 4357 1 0 0 1 26
3IVN_B 0.53 0.39 0.75 12 2330 4 2 2 0 19
3J3E_8 0.25 0.06 1.00 2 7501 2 0 0 2 31
3J3F_8 0.44 0.19 1.00 7 12239 0 0 0 0 29
3JYX_4 0.23 0.09 0.60 3 12241 4 0 2 2 30
3LA5_A 0.58 0.41 0.82 14 2468 3 1 2 0 20
3NPB_A 0.49 0.28 0.87 13 7006 2 1 1 0 33
3O58_3 0.45 0.20 1.00 7 12396 0 0 0 0 28
3PDR_A 0.44 0.19 1.00 14 12866 0 0 0 0 58
3RKF_A 0.53 0.35 0.80 12 2196 3 1 2 0 22
3SD1_A 0.47 0.26 0.85 11 3903 2 0 2 0 31
3W3S_B 0.41 0.23 0.75 9 4741 3 0 3 0 31
4A1C_2 0.46 0.21 1.00 7 11774 0 0 0 0 26
4AOB_A 0.58 0.33 1.00 14 4357 1 0 0 1 28
4ENB_A 0.56 0.32 1.00 6 1269 0 0 0 0 13
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13
4FRG_B 0.15 0.09 0.25 3 3474 9 0 9 0 29
4FRN_A 0.58 0.39 0.88 14 5135 2 1 1 0 22
4JF2_A 0.51 0.29 0.90 9 2840 2 0 1 1 22

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.