Design, synthesis and characterisation of a 34-residue polypeptide that interacts with nucleic acids
Overview of Gutte B et al.
| Authors | Gutte B Däumigen M Wittschieber E |
|---|---|
| Affiliation | nan |
| Journal | Nature |
| Year | 1979 |
Abstract
Based on secondary structure prediction rules and model building a neutral artificial 34-residue polypeptide with potential nucleic acid-binding activity was synthesised. This peptide and its covalent dimer showed strong interaction with cytidine phosphates and single-stranded DNA. The dimer had considerable ribonuclease activity with high preference for cleavage at the 3'-end of C.