Prediction of Intrinsically Unstructured Proteins (protein disorder) from amino acid sequence only.
Intrinsically unstructured proteins (IUPs) known also as unfolded proteins or disordered proteins are proteins characterized by lack of stable tertiary structure under physiological conditions. Moreover, such unfolded proteins remain functional. The intrinsic flexibility of disorder allows to form multiple interactions with various proteins by the same disordered protein. The prediction of protein disorder is important as IUPs are connected with many diseases (many key oncogens have large unstructured regions, e.g. p53 and BRCA1).
Metadisorder is one of the best predictors of protein disorder (evaluated during independent tests - CASP8 and CASP9)
Before running the method (it is quite expensive in case of time and resources) you may want to see exemplary graphical output or text output.
Metadisorder web service consists of four parts:
Contact: Lukasz Kozlowski
If you find MetaDisorder useful, please consider citing the reference that describes this work:
Kozlowski LP, Bujnicki JM. MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins. BMC Bioinformatics. 2012 May 24;13(1):111.
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This work was supported by Polish Ministry of Science and Higher Education (grant NN301 190139).