Summary:

NameAcute Myeloid Leukemia (xX:Xm)
DescriptionDecrease in 2'-O-Me due to knock-out of SNORD42A leads to a decrease in ribosomal proteins translation. 2'-O-Me impacts global protein translation by fine-tuning the synthesis of the translational machinery.
Related RNA reactionxX:Xm
Found in RNArRNA
Modified TranscriptrRNA 18S ( position U116)
Mapping TechnologyRiboMeth-Seq
Quantification techniquesqPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
962 Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acutemyeloid leukemia cell proliferation. Pauli C Blood [details] 32097467 S0006-4971(20)61978-4

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