| Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2). |
16046409 |
| Identification of a novel gene encoding a flavin-dependent tRNA:m5U methyltransferase in bacteria--evolutionary implications. |
16027442 |
| A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA. |
12810916 |
| Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. |
15375145 |
| Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC. |
17576679 |
| Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae. |
2063628 |
| Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. |
10445884 |
| Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. |
17475914 |
| The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity. |
9671058 |
| The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs. |
14561887 |
| Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code? |
15450604 |
| The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:Psi27/28-synthase. |
17684231 |
| Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. |
18025252 |
| The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. |
18668122 |
| IscS is a sulfurtransferase for the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. |
10600118 |
| Bioinformatic analyses of the tRNA: (guanine 26, N2,N2)-dimethyltransferase (Trm1) family. |
12125821 |
| Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. |
15899842 |
| Mechanistic investigations of the pseudouridine synthase RluA using RNA containing 5-fluorouridine. |
17002302 |
| Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. |
12355263 |
| Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. |
7806561 |
| Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase. |
14594807 |
| An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules. |
8336724 |
| A truncated aminoacyl-tRNA synthetase modifies RNA. |
15096612 |
| MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA. |
15339930 |
| A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase. |
14739239 |
| The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. |
16793063 |
| MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. |
11867542 |
| The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. |
10748051 |
| Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). |
15590684 |
| New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium. |
3129401 |
| Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli. |
7612632 |
| Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. |
11983179 |
| Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold. |
12001236 |
| The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties. |
10601028 |
| Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. |
17145781 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
9169867 |
| A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. |
15994936 |
| Biosynthesis of archaeosine, a novel derivative of 7-deazaguanosine specific to archaeal tRNA, proceeds via a pathway involving base replacement on the tRNA polynucleotide chain. |
9242689 |
| Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. |
15546625 |
| Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. |
11927565 |
| Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. |
11779873 |
| Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. |
10022901 |
| Genetic mapping and cloning of the gene (trmC) responsible for the synthesis of tRNA (mnm5s2U)methyltransferase in Escherichia coli K12. |
6387395 |
| Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. |
17189261 |
| Novel methyltransferase for modified uridine residues at the wobble position of tRNA. |
14645538 |
| Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase. |
17083917 |
| Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. |
16642040 |
| Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. |
14636587 |
| MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. |
8392589 |
| Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. |
10194318 |
| Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. |
11720289 |
| A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine. |
8347586 |
| An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. |
14527414 |
| The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase. |
12730187 |
| Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. |
2832378 |
| The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. |
12377117 |
| Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltransferase) enzymes. |
16963456 |
| Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. |
11142385 |
| The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium. |
14729701 |
| Sequence-structure-function studies of tRNA:m5C methyltransferase Trm4p and its relationship to DNA:m5C and RNA:m5U methyltransferases. |
15121902 |
| Transfer RNA(5-methylaminomethyl-2-thiouridine)-methyltransferase from Escherichia coli K-12 has two enzymatic activities. |
3298234 |
| Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism. |
16206323 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
9169875 |
| GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. |
10330157 |
| Isolation and characterization of the yeast mRNA capping enzyme beta subunit gene encoding RNA 5'-triphosphatase, which is essential for cell viability. |
9345280 |
| Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. |
14978044 |
| A second function for pseudouridine synthases: A point mutant of RluD unable to form pseudouridines 1911, 1915, and 1917 in Escherichia coli 23S ribosomal RNA restores normal growth to an RluD-minus strain. |
11453071 |
| Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. |
10556316 |
| The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. |
18025251 |
| Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. |
17010378 |
| The GTPase activity and C-terminal cysteine of the Escherichia coli MnmE protein are essential for its tRNA modifying function. |
12730230 |
| tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. |
12110595 |
| Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. |
9632712 |
| Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family. |
15637073 |
| Molecular cloning of the Escherichia coli miaA gene involved in the formation of delta 2-isopentenyl adenosine in tRNA. |
3045085 |
| Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. |
16162496 |
| The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coli. |
15928344 |
| Requirement for IscS in biosynthesis of all thionucleosides in Escherichia coli. |
12446632 |
| tRNA transfers to the limelight. |
12533506 |
| RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP. |
15870259 |
| Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant. |
9440525 |
| In vitro synthesis of selenocysteinyl-tRNA(UCA) from seryl-tRNA(UCA): involvement and characterization of the selD gene product. |
2405383 |
| Identification and characterization of RsmE, the founding member of a new RNA base methyltransferase family. |
16431987 |
| Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. |
15822125 |
| Cloning and restriction mapping of the trmA gene coding for transfer ribonucleic acid (5-methyluridine)-methyltransferase in Escherichia coli K-12. |
6247318 |
| Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae. |
10864043 |
| Structural features of the guide:target RNA duplex required for archaeal box C/D sRNA-guided nucleotide 2'-O-methylation. |
17438123 |
| The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. |
14970222 |
| The RNA Modification Database: 1999 update. |
9847178 |
| Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. |
16511203 |
| The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. |
15003446 |
| Identification of the tRNA-dihydrouridine synthase family. |
11983710 |
| An adenosine deaminase that generates inosine at the wobble position of tRNAs. |
10550050 |
| Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. |
15894617 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. |
9169869 |
| The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. |
16286935 |
| Glu-Q-tRNA(Asp) synthetase coded by the yadB gene, a new paralog of aminoacyl-tRNA synthetase that glutamylates tRNA(Asp) anticodon. |
16164993 |
| Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli. |
17062623 |
| A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. |
15766524 |
| Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli. |
15050828 |
| The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. |
15383682 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. |
9169873 |
| Identification of the miaB gene, involved in methylthiolation of isopentenylated A37 derivatives in the tRNA of Salmonella typhimurium and Escherichia coli. |
10572129 |
| Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. |
11319236 |
| Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus. |
11763974 |
| Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. |
9843512 |
| GAR1 is an essential small nucleolar RNP protein required for pre-rRNA processing in yeast. |
1531632 |
| Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis. |
15789416 |
| Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. |
12403464 |
| The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation. |
16601205 |
| Cloning and characterization of the Schizosaccharomyces pombe tRNA:pseudouridine synthase Pus1p. |
11095668 |
| The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. |
16043508 |
| Identification of the Saccharomyces cerevisiae RNA:pseudouridine synthase responsible for formation of psi(2819) in 21S mitochondrial ribosomal RNA. |
10756195 |
| In silico analysis of the tRNA:m1A58 methyltransferase family: homology-based fold prediction and identification of new members from Eubacteria and Archaea. |
11684083 |
| The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. |
9851972 |
| The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. |
17242307 |
| Phylogenomic analysis of 16S rRNA:(guanine-N2) methyltransferases suggests new family members and reveals highly conserved motifs and a domain structure similar to other nucleic acid amino-methyltransferases. |
11053259 |
| The structural gene (trmD) for the tRNA(m1G)methyltransferase is part of a four polypeptide operon in Escherichia coli K-12. |
6298574 |
| Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8. |
17114947 |
| Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. |
17727881 |
| Transfer RNA recognition by the Escherichia coli delta2-isopentenyl-pyrophosphate:tRNA delta2-isopentenyl transferase: dependence on the anticodon arm structure. |
9214656 |
| Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination. |
7954819 |
| Genetic dissection of synthesis and function of modified nucleosides in bacterial transfer RNA. |
7538683 |
| The crystal structure of E. coli rRNA pseudouridine synthase RluE. |
17320904 |
| An aminoacyl-tRNA synthetase-like protein encoded by the Escherichia coli yadB gene glutamylates specifically tRNAAsp. |
15096594 |
| Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop. |
10828971 |
| The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast. |
7590228 |
| How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. |
17466622 |
| Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. |
11567089 |
| The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. |
10779558 |
| Isolation and characterization of MOD5, a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae. |
3031456 |
| A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya. |
12756329 |
| Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. |
11697862 |
| Formation of the conserved pseudouridine at position 55 in archaeal tRNA. |
16920741 |
| Sequence analysis and structure prediction of aminoglycoside-resistance 16S rRNA:m7G methyltransferases. |
11518396 |
| RluD, a highly conserved pseudouridine synthase, modifies 50S subunits more specifically and efficiently than free 23S rRNA. |
17872507 |
| SPL1-1, a Saccharomyces cerevisiae mutation affecting tRNA splicing. |
8444805 |
| The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA. |
15037780 |
| RNA methylation under heat shock control. |
10983982 |
| Crystal structure of human Pus10, a novel pseudouridine synthase. |
17900615 |
| Substrate specificity and properties of the Escherichia coli 16S rRNA methyltransferase, RsmE. |
17872509 |
| The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. |
18208838 |
| The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. |
9321663 |
| Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways. |
14729702 |
| Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. |
17875999 |
| Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind S-adenosyl-L-methionine in vitro. |
10648622 |
| Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae. |
15466869 |
| MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli. |
12549933 |
| YebU is a m5C methyltransferase specific for 16 S rRNA nucleotide 1407. |
16678201 |
| YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. |
18755835 |
| Structure of the pseudouridine synthase RsuA from Haemophilus influenzae. |
16511038 |
| Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. |
17238915 |
| The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding. |
11206077 |
| Translational defects of Escherichia coli mutants deficient in the Um(2552) 23S ribosomal RNA methyltransferase RrmJ/FTSJ. |
10814528 |
| The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA. |
9660827 |
| Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex. |
15755920 |
| Crystal structure of IscS, a cysteine desulfurase from Escherichia coli. |
12860127 |
| A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. |
12003496 |
| A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. |
16005430 |
| The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. |
9917067 |
| Insights into catalysis by a knotted TrmD tRNA methyltransferase. |
14583191 |
| The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase. |
16848900 |
| Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae. |
1325384 |
| The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. |
18021804 |
| A primordial tRNA modification required for the evolution of life? |
11226173 |
| MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. |
9774408 |
| RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex). |
17382321 |
| The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression. |
8444796 |
| Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. |
1706703 |
| Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry. |
12907714 |
| Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. |
14566049 |
| Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. |
8972218 |
| Disruption and functional analysis of six ORFs of chromosome IV: YDL103c (QRI1), YDL105w (QRI2), YDL112w (TRM3), YDL113c, YDL116w (NUP84) and YDL167c (NRP1). |
11180460 |
| Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. |
17338813 |
| Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. |
12384598 |
| Identification of a gene involved in the generation of 4-thiouridine in tRNA. |
9592144 |
| tRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast. |
16390459 |
| Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop. |
9430663 |
| Active site in RrmJ, a heat shock-induced methyltransferase. |
12181314 |
| tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase. |
17679698 |
| Functional requirement of a site-specific ribose methylation in ribosomal RNA. |
8266080 |
| Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae. |
11452018 |
| Ribosomal RNA guanine-(N2)-methyltransferases and their targets. |
17389639 |
| Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. |
7623811 |
| mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. |
11472630 |
| Reduced misreading of asparagine codons by Escherichia coli tRNALys with hypomodified derivatives of 5-methylaminomethyl-2-thiouridine in the wobble position. |
9811540 |
| Structural insights into the GTPase domain of Escherichia coli MnmE protein. |
17143896 |
| The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium. |
12446633 |
| Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold. |
15208439 |
| Identification of a bifunctional enzyme MnmC involved in the biosynthesis of a hypermodified uridine in the wobble position of tRNA. |
15247431 |
| Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits. |
18332120 |
| A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe). |
7493321 |
| Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. |
15016356 |
| Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. |
2298745 |
| Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution. |
16540698 |
| Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain. |
16343540 |
| Identification and characterization of the tRNA:Psi 31-synthase (Pus6p) of Saccharomyces cerevisiae. |
11406626 |
| Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis. |
16053518 |
| Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification. |
15983041 |
| Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. |
16826519 |
| Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. |
16427014 |
| Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA. |
17010380 |
| Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli. |
10089432 |
| The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK). |
18420655 |
| Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. |
16433904 |
| The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. |
9472021 |
| The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli. |
11698387 |
| Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants. |
17573471 |
| Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold. |
14999002 |
| The structure of the TrmE GTP-binding protein and its implications for tRNA modification. |
15616586 |
| Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. |
12702816 |
| Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. |
9707437 |
| The carboxyl-terminal extension of yeast tRNA m5C methyltransferase enhances the catalytic efficiency of the amino-terminal domain. |
17567576 |
| RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited--bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure. |
11929612 |
| Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae. |
2426253 |
| The ribosomal components responsible for kasugamycin dependence, and its suppression, in a mutant of Escherichia coli. |
6988670 |
| Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site. |
14999102 |
| Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. |
9372940 |
| Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase. |
12907733 |
| Assembly of the archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling. |
16949610 |
| Structural bioinformatics analysis of enzymes involved in the biosynthesis pathway of the hypermodified nucleoside ms(2)io(6)A37 in tRNA. |
17910062 |
| Transfer RNA modification enzymes from Pyrococcus furiosus: detection of the enzymatic activities in vitro. |
9973619 |
| Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli. |
10026269 |
| mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae. |
1315757 |
| Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase. |
15850396 |
| Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure. |
17188032 |
| Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. |
12496758 |
| Isolation of the gene (miaE) encoding the hydroxylase involved in the synthesis of 2-methylthio-cis-ribozeatin in tRNA of Salmonella typhimurium and characterization of mutants. |
8253666 |
| Sequence analysis of a 13.4 kbp fragment from the left arm of chromosome XV reveals a malate dehydrogenase gene, a putative Ser/Thr protein kinase, the ribosomal L25 gene and four new open reading frames. |
8896265 |
| Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. |
16763562 |
| Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations. |
16513084 |
| The K-loop, a general feature of the Pyrococcus C/D guide RNAs, is an RNA structural motif related to the K-turn. |
16293637 |
| Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA. |
10383384 |
| THUMP--a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. |
11295541 |
| tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p. |
15811913 |
| Purification, structure, and properties of Escherichia coli tRNA pseudouridine synthase I. |
3276686 |
| A minimalist glutamyl-tRNA synthetase dedicated to aminoacylation of the tRNAAsp QUC anticodon. |
15150343 |
| Structure of tRNA dimethylallyltransferase: RNA modification through a channel. |
17292915 |
| Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA. |
16712869 |
| From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold. |
15767583 |
| Transfer and isomerization of the ribose moiety of AdoMet during the biosynthesis of queuosine tRNAs, a new unique reaction catalyzed by the QueA protein from Escherichia coli. |
7849103 |
| The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. |
15923376 |
| Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding. |
17524419 |
| Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency. |
12058040 |
| Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). |
17384192 |
| Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli. |
9873033 |
| The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs. |
9358157 |
| 16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp102 residue, and sequence comparison among all other pseudouridine synthases. |
10376875 |
| Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. |
17440925 |
| Sequential 2'-O-methylation of archaeal pre-tRNATrp nucleotides is guided by the intron-encoded but trans-acting box C/D ribonucleoprotein of pre-tRNA. |
15347671 |
| A purified selenophosphate-dependent enzyme from Salmonella typhimurium catalyzes the replacement of sulfur in 2-thiouridine residues in tRNAs with selenium. |
7520175 |
| Analysis of Snu13p mutations reveals differential interactions with the U4 snRNA and U3 snoRNA. |
14730029 |
| Posttranscriptional modifications in the A-loop of 23S rRNAs from selected archaea and eubacteria. |
11911366 |
| The archaeon Haloarcula marismortui has few modifications in the central parts of its 23S ribosomal RNA. |
15826654 |
| Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria. |
20007606 |
| Structural basis for methyl transfer by a radical SAM enzyme. |
21527678 |
| A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. |
16091044 |
| Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria. |
19144912 |
| RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA |
20184321 |
| RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift. |
21368151 |
| YgdE is the 2'-O-ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA. |
19400805 |
| YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962. |
18786544 |
| Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes. |
18789337 |
| Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA. |
18186482 |
| Assay of both activities of the bifunctional tRNA-modifying enzyme MnmC reveals a kinetic basis for selective full modification of cmnm5s2U to mnm5s2U. |
21306992 |
| Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli. |
21574198 |
| Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate. |
18565343 |
| Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1. |
18840651 |
| Snapshots of tRNA sulphuration via an adenylated intermediate. |
16871210 |
| The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. |
14656444 |
| Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. |
18451029 |
| Structure of the yeast tRNA m7G methylation complex. |
18184583 |
| Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase. |
19847269 |
| Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. |
19520088 |
| Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. |
10589681 |
| X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold. |
15135053 |
| Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. |
16700551 |
| Pre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA, and RluA reveals uniformly slow catalysis. |
21998096 |
| Control of catalytic cycle by a pair of analogous tRNA modification enzymes. |
20452364 |
| Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA. |
18952823 |
| A previously unidentified activity of yeast and mouse RNA:pseudouridine synthases 1 (Pus1p) on tRNAs. |
16804160 |
| RNA:pseudouridine synthetase Pus1 from Saccharomyces cerevisiae: oligomerization property and stoichiometry of the complex with yeast tRNA(Phe). |
10492022 |
| Pseudouridine synthetase Pus1 of Saccharomyces cerevisiae: kinetic characterisation, tRNA structural requirement and real-time analysis of its complex with tRNA. |
10356324 |
| Transfer RNA-pseudouridine synthetase Pus1 of Saccharomyces cerevisiae contains one atom of zinc essential for its native conformation and tRNA recognition. |
9585540 |
| Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift. |
11544186 |
| Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions. |
19767610 |
| Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. |
15509579 |
| tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis. |
14633974 |
| tRNAHis guanylyltransferase (THG1), a unique 3′-5′ nucleotidyl transferase, shares unexpected structural homology with canonical 5′-3′ DNA polymerases. |
21059936 |
| YhiQ Is RsmJ, the Methyltransferase Responsible for Methylation of G1516 in 16S rRNA of E. coli. |
22079366 |
| Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA. |
19965768 |
| Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA. |
21723290 |
| Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides. |
2441068 |
| Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. |
20639535 |
| Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit. |
21062819 |
| Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification. |
21502530 |
| Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. |
17284461 |
| Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)U. |
21687733 |
| Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast. |
20400505 |
| The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC). |
19383770 |
| Point mutations in yeast CBF5 can abolish in vivo pseudouridylation of rRNA. |
10523634 |
| 3-(3-amino-3-carboxypropyl)-5,6-Dihydrouridine is one of two novel post-transcriptional modifications in tRNA(Lys) (UUU) from Trypanosoma brucei. |
22040320 |
| The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA. |
20972225 |
| Structure of wye (Yt base) and wyosine (Yt) from Torulopsis utilis phenylalanine transfer ribonucleic acid. |
942858 |
| Studies on polynucleotides, lxviii the primary structure of yeast phenylalanine transfer RNA. |
16591527 |
| A specific modification next to the anticodon of phenylalanine transfer ribonucleic acid. |
5698615 |
| A fluorescence assay for phenylalanine transfer RNA. |
5722700 |
| Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5. |
20980671 |
| Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase. |
17652090 |
| Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein. |
15248782 |
| Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. |
19287006 |
| Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea. |
20382657 |
| Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis. |
17881823 |
| Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2. |
19717466 |
| Biosynthesis and function of tRNA modifications in Archaea. |
21470902 |
| Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14. |
21693558 |
| Agmatidine, a modified cytidine in the anticodon of archaeal tRNA(Ile), base pairs with adenosine but not with guanosine. |
20133752 |
| Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea. |
20139989 |
| Structural basis of tRNA agmatinylation essential for AUA codon decoding. |
22002223 |
| The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. |
1825809 |
| A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. |
8508778 |
| Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast. |
2026646 |
| An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs. |
1714385 |
| Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes. |
14583623 |
| cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. |
1846968 |
| Structural organization of box C/D RNA-guided RNA methyltransferase. |
19666563 |
| Structural basis for site-specific ribose methylation by box C/D RNA protein complexes. |
21270896 |
| Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. |
10654930 |
| Expression, purification and preliminary X-ray analysis of a fibrillarin homolog from Methanococcus jannaschii, a hyperthermophile. |
10089444 |
| Structure determination of fibrillarin from the hyperthermophilic archaeon Pyrococcus furiosus. |
14975761 |
| Alternative conformations of the archaeal Nop56/58-fibrillarin complex imply flexibility in box C/D RNPs. |
17617422 |
| Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. |
20864039 |
| Structural and thermodynamic evidence for a stabilizing role of Nop5p in S-adenosyl-L-methionine binding to fibrillarin. |
15286083 |
| Structure and function of archaeal box C/D sRNP core proteins. |
12598892 |
| The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs. |
16008351 |
| Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA at 1.8 A resolution. |
15130481 |
| Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea. |
12560482 |
| Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA. |
15130473 |
| Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. |
21366326 |
| Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment. |
11163207 |
| Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. |
17412961 |
| Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA. |
10545122 |
| A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation. |
20962039 |
| Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing. |
21556049 |
| The ms2io6A37 modification of tRNA in Salmonella typhimurium regulates growth on citric acid cycle intermediates. |
9620964 |
| The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons. |
17942742 |
| Isolation of 5-hydroxyuridine (iso-barbituridine) from yeast ribonucleic acids. |
5957714 |
| 5-methoxyuridine: a new minor constituent located in the first position of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis. |
825836 |
| Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. |
11746687 |
| The identification of the tRNA substrates for the supK tRNA methylase. |
347399 |
| The presence of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]threonine in serine, methionine and lysine transfer RNA's from Escherichia coli. |
4902784 |
| Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon. |
19446527 |
| Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy. |
19806182 |
| Characterization of GTPase activity of TrmE, a member of a novel GTPase superfamily, from Thermotoga maritima. |
11092873 |
| Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. |
17706197 |
| Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA. |
15944150 |
| Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. |
20404999 |
| Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions. |
16387657 |
| High precision NMR structure of YhhP, a novel Escherichia coli protein implicated in cell division. |
11080457 |
| Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex. |
16472754 |
| Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. |
14722066 |
| Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases. |
21910628 |
| Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs. |
21957023 |
| Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity. |
22210896 |
| Chemical incorporation of 1‑methyladenosine into oligonucleotides |
11861902 |
| The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity. |
18391219 |
| Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. |
19145231 |
| Uridin-5-oxy acetic acid: a new minor constituent from E. coli valine transfer RNA I. |
4910247 |
| Identification of the chloroplast adenosine-to-inosine tRNA editing enzyme. |
19460869 |
| Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg(ACG) and is essential for efficient chloroplast translation. |
19602623 |
| A-to-I and C-to-U editing within transfer RNAs. |
22022967 |
| Determinants of tRNA editing and modification: Avoiding conundrums, affecting function. |
22024020 |
| A cytidine deaminase edits C to U in transfer RNAs in Archaea. |
19407206 |
| Insights into folate/FAD-dependent tRNA methyltransferase mechanism: role of two highly conserved cysteines in catalysis. |
21846722 |
| A catalytic intermediate and several flavin redox states stabilized by folate-dependent tRNA methyltransferase from Bacillus subtilis. |
21561081 |
| Expression and purification of untagged and histidine-tagged folate-dependent tRNA:m5U54 methyltransferase from Bacillus subtilis. |
20412857 |
| Enzymatic formation of queuosine and of glycosyl queuosine in yeast tRNAs microinjected into Xenopus laevis oocytes. The effect of the anticodon loop sequence. |
3117541 |
| Structure, biosynthesis, and function of queuosine in transfer RNA. |
6410456 |
| Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver. |
20603 |
| Determination of queuosine derivatives by reverse-phase liquid chromatography for the hypomodification study of Q-bearing tRNAs from various mammal liver cells. |
14751792 |
| Letter: The structure of Q* nucleoside isolated from rabbit liver transfer ribonucleic acid. |
950430 |
| Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase. |
19416846 |
| Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase. |
22085967 |
| New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. |
17283215 |
| Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita. |
22117216 |
| Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA. |
16373493 |
| Box H/ACA small ribonucleoproteins. |
20227365 |
| The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. |
19917616 |
| A single zinc ion is sufficient for an active Trypanosoma brucei tRNA editing deaminase. |
21507956 |
| The C-terminal end of the Trypanosoma brucei editing deaminase plays a critical role in tRNA binding. |
21602302 |
| An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA. |
17483465 |
| A novel link between the biosynthesis of aromatic amino acids and transfer RNA modification in Escherichia coli. |
6160251 |
| The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA. |
22274953 |
| Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs. |
22274954 |
| Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase. |
21098051 |
| Discovery and characterization of tRNAIle lysidine synthetase (TilS). |
19944692 |
| Life without the essential bacterial tRNA Ile2-lysidine synthetase TilS: a case of tRNA gene recruitment in Bacillus subtilis. |
21435031 |
| Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS. |
22002222 |
| Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors. |
19037260 |
| Identification of two tRNA thiolation genes required for cell growth at extremely high temperatures. |
16547008 |
| Evidence that ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis, may be a sulfurtransferase that proceeds through a persulfide intermediate. |
10722656 |
| Evidence for the transfer of sulfane sulfur from IscS to ThiI during the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. |
10753862 |
| The role of the cysteine residues of ThiI in the generation of 4-thiouridine in tRNA. |
11443125 |
| A paradigm for biological sulfur transfers via persulfide groups: a persulfide-disulfide-thiol cycle in 4-thiouridine biosynthesis. |
12510310 |
| Deduced RNA binding mechanism of ThiI based on structural and binding analyses of a minimal RNA ligand. |
19509301 |
| Direct evidence that ThiI is an ATP pyrophosphatase for the adenylation of uridine in 4-thiouridine biosynthesis. |
18604845 |
| Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis. |
16855700 |
| Modifications Modulate Anticodon Loop Dynamics and Codon Recognition of E. coli tRNA(Arg1,2). |
22240457 |
| Thiobases in Escherchia coli Transfer RNA: 2-Thiocytosine and 5-Methylaminomethyl-2-thiouracil. |
17812290 |
| Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer. |
18191630 |
| A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast. |
17592039 |
| The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. |
18063569 |
| Overexpression, crystallization and preliminary X-ray crystallographic analysis of Pseudomonas aeruginosa MnmE, a GTPase involved in tRNA modification. |
20693664 |
| RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon. |
19322199 |
| Synthesis of 2′-O-[(Triisopropylsilyl)oxy]methyl (= tom)-Protected Ribonucleoside Phosphoramidites Containing Various Nucleobase Analogues |
10.1002/hlca.200590209 |
| Site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry. |
7599270 |
| The synthesis of 2'-O-[(Triisopropylsilyl)oxy] methyl (TOM) phosphoramidites of methylated ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for use in automated RNA solid-phase synthesis |
|
| Synthesis of the Anticodon Hairpin tRNAfMet Containing N-{[9-(β-D-Ribofuranosyl)-9H-purin-6-yl]carbamoyl}-L-threonine (=N6-{{[(1S,2R)-1-Carboxy-2-hydroxypropyl]amino}carbonyl}adenosine, t6A) |
10.1002/(SICI)1522-2675(20000119)83:1<152::AID-HLC |
| The nucleotide sequence of a threonine transfer ribonucleic acid from Escherichia coli. |
4608712 |
| Nucleotide sequence of tRNA(Thr1) of Escherichia coli and of the gene (thrV) that encodes it. |
1380693 |
| Synthesis and Characterization of the Native Anticodon Domain of E. coli tRNALys: Simultaneous Incorporation of Modified Nucleosides mnm5s2U, t6A, and Pseudouridine Using Phosphoramidite Chemistry |
10970299 |
| Synthesis of the tRNALys,3 Anticodon Stem-Loop Domain Containing the Hypermodified ms2t6A Nucleoside |
12126427 |
| An Improved Synthesis of Inosine 3′-Phosphoramidite |
10.1080/00397910008086956 |
| Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin. |
11741781 |
| Synthesis of helix 69 of Escherichia coli 23S rRNA containing its natural modified nucleosides, m(3)Psi and Psi. |
12467398 |
| Mutagenesis of the peptidyltransferase center of 23S rRNA: the invariant U2449 is dispensable. |
11160893 |
| Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability. |
9092639 |
| Solid phase synthesis of the 5'-half of the initiator t-RNA from B. subtilis. |
2508060 |
| Site-directed cleavage of RNA. |
2438655 |
| Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides. |
3627981 |
| Synthesis of N-Methylated Ribonucleosides for RNA Synthesis |
10.1002/hlca.200390205 |
| The synthesis of oligoribonucleotides containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines via post-synthetic modification of precursor oligomers. |
12888506 |
| Introduction of hypermodified nucleotides in RNA. |
15333904 |
| Synthesis and Incorporation of 2′-O-Methyl-Pseudouridine into Oligonucleotides |
10.1080/07328319708006226 |
| New and convenient protection system for pseudouridine, highly suitable for solid-phase oligoribonucleotide synthesis |
10.1039/P19940003423 |
| Chemical synthesis of a biologically active natural tRNA with its minor bases. |
1383941 |
| Chemical synthesis of RNA including 5-taurinomethyluridine |
10.1093/nass/nrl005 |
| Unique structural and stabilizing roles for the individual pseudouridine residues in the 1920 region of Escherichia coli 23S rRNA. |
10773075 |
| A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA. |
19416889 |
| LC/MS analysis of cellular RNA reveals NAD-linked RNA. |
19820715 |
| Nucleotide sequence of nuclear 5.4 S RNA of mouse cells. |
6202321 |
| Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth. |
8552073 |
| Structure-function analysis of the mRNA cap methyltransferase of Saccharomyces cerevisiae. |
9169431 |
| Dynamic association of capping enzymes with transcribing RNA polymerase II. |
11018011 |
| Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae. |
20454621 |
| Trm112 Is Required for Bud23-Mediated Methylation of the 18S rRNA at Position G1575. |
22493060 |
| Isolation of temperature-sensitive mutants for mRNA capping enzyme in Saccharomyces cerevisiae. |
7500935 |
| Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization. |
3029058 |
| Structure of the Saccharomyces cerevisiae Cet1-Ceg1 mRNA capping apparatus. |
20159466 |
| The essential interaction between yeast mRNA capping enzyme subunits is not required for triphosphatase function in vivo. |
11094081 |
| Molecular determinants of dihydrouridine synthase activity. |
16962594 |
| Crystal structure of glutamyl-queuosine tRNAAsp synthetase complexed with L-glutamate: structural elements mediating tRNA-independent activation of glutamate and glutamylation of tRNAAsp anticodon. |
18602926 |
| Structural insights into mechanisms of the small RNA methyltransferase HEN1. |
19812675 |
| Kinetic and functional analysis of the small RNA methyltransferase HEN1: the catalytic domain is essential for preferential modification of duplex RNA. |
20705645 |
| Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. |
16111943 |
| Methylation as a crucial step in plant microRNA biogenesis. |
15705854 |
| siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. |
20448024 |
| HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide. |
16449203 |
| Yeast targets for mRNA methylation. |
20421205 |
| Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon. |
19435325 |
| RNA-protein mutually induced fit: structure of Escherichia coli isopentenyl-tRNA transferase in complex with tRNA(Phe). |
19158097 |
| Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: a binding mechanism for recombinant enzyme. |
9012675 |
| Enzymatic modification of tRNAs: MiaB is an iron-sulfur protein. |
11882645 |
| Evidence that the folate-dependent proteins YgfZ and MnmEG have opposing effects on growth and on activity of the iron-sulfur enzyme MiaB. |
22081392 |
| TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes. |
11313137 |
| Enzymology of tRNA modification in the bacterial MnmEG pathway. |
22386868 |
| Saccharomyces cerevisiae Mod5p-II contains sequences antagonistic for nuclear and cytosolic locations. |
9872948 |
| Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases. |
21873461 |
| Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. |
12527203 |
| Implications of a functional large ribosomal RNA with only three modified nucleotides. |
7541254 |
| Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. |
19151091 |
| A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. |
18755837 |
| Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems. |
18664566 |
| Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. |
21087996 |
| Biosynthesis of a hypermodified nucleotide in Saccharomyces carlsbergensis 17S and HeLa-cell 18S ribosomal ribonucleic acid. |
629754 |
| Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases. |
19135144 |
| RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine. |
12220187 |
| Psi35 in the branch site recognition region of U2 small nuclear RNA is important for pre-mRNA splicing in Saccharomyces cerevisiae. |
15611063 |
| X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. |
18435545 |
| Different mechanisms for pseudouridine formation in yeast 5S and 5.8S rRNAs. |
18332121 |
| RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p. |
19114708 |
| Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. |
14660578 |
| Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase. |
15388872 |
| Mutagenesis of the modified bases, m(5)U1939 and psi2504, in Escherichia coli 23S rRNA. |
20067766 |
| Methylated 23S rRNA nucleotide m2G1835 of Escherichia coli ribosome facilitates subunit association. |
21237242 |
| Identification of pseudouridine methyltransferase in Escherichia coli. |
18755836 |
| Specificity and kinetics of 23S rRNA modification enzymes RlmH and RluD. |
20817755 |
| 5-methylcytosine in RNA: detection, enzymatic formation and biological functions. |
20007150 |
| Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA. |
22362734 |
| Radical-mediated enzymatic methylation: a tale of two SAMS. |
22097883 |
| Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation. |
21916495 |
| Pseudouridines and pseudouridine synthases of the ribosome. |
12762017 |
| Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli. |
15078091 |
| Identification of two Escherichia coli pseudouridine synthases that show multisite specificity for 23S RNA. |
9843401 |
| Crystal structure of the catalytic domain of RluD, the only rRNA pseudouridine synthase required for normal growth of Escherichia coli. |
14730022 |
| Substrate specificity of the pseudouridine synthase RluD in Escherichia coli. |
17937767 |
| Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli. |
14659742 |
| Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. |
19298824 |
| Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases. |
19303884 |
| Structural insights into methyltransferase KsgA function in 30S ribosomal subunit biogenesis. |
22308031 |
| Site-directed mutants of 16S rRNA reveal important RNA domains for KsgA function and 30S subunit assembly. |
21142019 |
| Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA. |
18990185 |
| Control of substrate specificity by a single active site residue of the KsgA methyltransferase. |
22142337 |
| Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. III. Purification and properties of the methylating enzyme and methylase-30 S interactions. |
383712 |
| Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16S ribosomal RNA of Escherichia coli. IV. The effect of the methylgroups on ribosomal subunit interaction. |
6986611 |
| The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast. |
8064863 |
| Comprehensive phylogenetic analysis of evolutionarily conserved rRNA adenine dimethyltransferase suggests diverse bacterial contributions to the nucleus-encoded plastid proteome. |
19017544 |
| Dim2p, a KH-domain protein required for small ribosomal subunit synthesis. |
15037774 |
| Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? |
9528805 |
| A paradigm for local conformational control of function in the ribosome: binding of ribosomal protein S19 to Escherichia coli 16S rRNA in the presence of S7 is required for methylation of m2G966 and blocks methylation of m5C967 by their respective methyltransferases. |
1766869 |
| Properties of small rRNA methyltransferase RsmD: Mutational and kinetic study. |
22535590 |
| The aminoglycoside resistance methyltransferase Sgm impedes RsmF methylation at an adjacent rRNA nucleotide in the ribosomal A site. |
19509304 |
| Regulation of expression and catalytic activity of Escherichia coli RsmG methyltransferase. |
22337945 |
| Deletion of gene encoding methyltransferase (gidB) confers high-level antimicrobial resistance in Salmonella. |
22318332 |
| Influence of phylogeny on posttranscriptional modification of rRNA in thermophilic prokaryotes: the complete modification map of 16S rRNA of Thermus thermophilus. |
16605256 |
| Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP. |
11953756 |
| The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA. |
19287007 |
| The Sua5 protein is essential for normal translational regulation in yeast. |
19884342 |
| Doing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily. |
22456265 |
| Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding. |
17932071 |
| Structural comparison of tRNA m(1)A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions. |
22168821 |
| The 2-thiouridylase function of the human MTU1 (TRMU) enzyme is dispensable for mitochondrial translation. |
21890497 |
| YrdC exhibits properties expected of a subunit for a tRNA threonylcarbamoyl transferase. |
21775474 |
| Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside. |
22378793 |
| Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames. |
10649453 |
| Crystal structure of archaeosine tRNA-guanine transglycosylase. |
12054814 |
| Alternative tertiary structure of tRNA for recognition by a posttranscriptional modification enzyme. |
12732145 |
| Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline. |
16768442 |
| Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. |
19749755 |
| Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA. |
18068186 |
| The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP. |
15987815 |
| The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)-methyltransferase provides insights into its tRNA specificity. |
18653523 |
| Acquisition of a bacterial RumA-type tRNA(uracil-54, C5)-methyltransferase by Archaea through an ancient horizontal gene transfer. |
18069966 |
| The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya. |
19143597 |
| The activity of an ancient atypical protein kinase is stimulated by ADP-ribose in vitro. |
21527241 |
| Structure-function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life. |
12023889 |
| Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs. |
15388873 |
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA. |
19478803 |
| Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. |
18951093 |
| A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. |
16564010 |
| Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3' terminal RNA ribose 2'O-methyltransferase. |
21205839 |
| Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. |
19822745 |
| Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette. |
20007328 |
| Probing the substrate specificity of the bacterial Pnkp/Hen1 RNA repair system using synthetic RNAs. |
22190744 |
| Reconstituting bacterial RNA repair and modification in vitro. |
19815768 |
| An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro. |
17766251 |
| The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. |
21183954 |
| A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification. |
21285948 |
| Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. |
21459853 |
| Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. |
19172740 |
| Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis. |
20472640 |
| MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters. |
17407324 |
| MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase. |
12766153 |
| S-Adenosylmethionine-dependent radical-based modification of biological macromolecules. |
20951571 |
| Identification of a tRNA isopentenyltransferase gene from Arabidopsis thaliana. |
11999372 |
| Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis. |
17062755 |
| Cloning of a human tRNA isopentenyl transferase. |
11111046 |
| Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. |
20584901 |
| Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. |
21841312 |
| Backbone resonance assignments of the 48 kDa dimeric putative 18S rRNA-methyltransferase Nep1 from Methanocaldococcus jannaschii. |
19779849 |
| The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. |
20047967 |
| Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases. |
21051506 |
| Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance. |
19578062 |
| Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I. |
18406425 |
| Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II). |
17673230 |
| The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. |
15046978 |
| A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA. |
21824914 |
| Cloning and characterization of the 23S RNA pseudouridine 2633 synthase from Bacillus subtilis. |
9888802 |
| Structural basis for binding of RNA and cofactor by a KsgA methyltransferase. |
19278652 |
| A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis. |
19929881 |
| Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. |
17031457 |
| Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. |
20163168 |
| Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. |
19285505 |
| Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance. |
19001112 |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
20558545 |
| Crystal structure of the Thermus thermophilus 16 S rRNA methyltransferase RsmC in complex with cofactor and substrate guanosine. |
18667428 |
| Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition. |
21474448 |
| Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG. |
19622680 |
| Crystal structure of Sulfolobus tokodaii Sua5 complexed with L-threonine and AMPPNP. |
21538543 |
| X-ray crystal structure of a hypothetical Sua5 protein from Sulfolobus tokodaii strain 7. |
18004774 |
| Crystal structure of tRNA adenosine deaminase (TadA) from Aquifex aeolicus. |
15677468 |
| Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. |
16415880 |
| Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme. |
7665516 |
| Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange. |
8654383 |
| Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity. |
10413112 |
| Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure. |
21844194 |
| Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA. |
19491098 |
| Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii. |
18789948 |
| Crystal structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin. |
20600111 |
| THUMP from archaeal tRNA:m22G10 methyltransferase, a genuine autonomously folding domain. |
16687654 |
| N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota. |
15210688 |
| YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. |
20855540 |
| The open reading frame TTC1157 of Thermus thermophilus HB27 encodes the methyltransferase forming N(2)-methylguanosine at position 6 in tRNA. |
22337946 |
| Conformational change of pseudouridine 55 synthase upon its association with RNA substrate. |
14990747 |
| Conserved network of proteins essential for bacterial viability. |
19376873 |
| Effects on transcription of mutations in ygjD, yeaZ, and yjeE genes, which are involved in a universal tRNA modification in Escherichia coli. |
21873492 |
| Structural analysis of the essential resuscitation promoting factor YeaZ suggests a mechanism of nucleotide regulation through dimer reorganization. |
21858042 |
| Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 A resolution. |
20944216 |
| The structure of the hypothetical protein smu.1377c from Streptococcus mutans suggests a role in tRNA modification. |
20606270 |
| The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. |
19246765 |
| Known bioactive small molecules probe the function of a widely conserved but enigmatic bacterial ATPase, YjeE. |
19101473 |
| Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. |
16333325 |
| The methyl group of the N6-methyl-N6-threonylcarbamoyladenosine in tRNA of Escherichia coli modestly improves the efficiency of the tRNA. |
9537379 |
| Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I. |
18931107 |
| The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps. |
19354300 |
| Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli. |
16199558 |
| Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis. |
18491386 |
| Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase. |
19231875 |
| Functional promiscuity of the COG0720 family. |
21999246 |
| Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis. |
18259064 |
| Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. |
14660579 |
| Mechanistic studies of Bacillus subtilis QueF, the nitrile oxidoreductase involved in queuosine biosynthesis. |
17929836 |
| Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures. |
12682365 |
| Crystal structure of Thermus thermophilus tRNA m1A58 methyltransferase and biophysical characterization of its interaction with tRNA. |
18262540 |
| Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase. |
14960715 |
| Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv. |
11554794 |
| Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. |
22065580 |
| Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. |
20308323 |
| ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. |
21285950 |
| The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. |
20583019 |
| Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. |
21518805 |
| A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. |
21518804 |
| Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase. |
16600901 |
| Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. |
20123966 |
| An early step in wobble uridine tRNA modification requires the Elongator complex. |
15769872 |
| Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. |
9512541 |
| Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. |
9473487 |
| Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. |
9705270 |
| Structure of the guanylyltransferase domain of human mRNA capping enzyme. |
21636784 |
| Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. |
9790902 |
| Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. |
10347220 |
| Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. |
11114884 |
| Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. |
15767670 |
| RAM/Fam103a1 is required for mRNA cap methylation. |
22099306 |
| Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. |
18775984 |
| Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1. |
19307714 |
| Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. |
20713356 |
| The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity. |
18533109 |
| Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. |
19386620 |
| 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. |
21310715 |
| Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. |
17643375 |
| A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP. |
19906723 |
| Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. |
15068804 |
| The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. |
12198172 |
| Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. |
12871939 |
| Functional link between the mammalian exosome and mRNA decapping. |
11747811 |
| DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. |
14523240 |
| Functional analysis of mRNA scavenger decapping enzymes. |
15273322 |
| The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. |
12828631 |
| Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. |
12742024 |
| An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. |
11181344 |
| Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. |
15581897 |
| Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis. |
3087948 |
| Substrate requirements for ErmC' methyltransferase activity. |
7543473 |
| Family background of children with Down's syndrome and of children with a similar degree of mental retardation. |
2946350 |
| Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions. |
12907737 |
| Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria. |
9585521 |
| The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. |
10366505 |
| Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545. |
2163525 |
| Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. |
9187657 |
| Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
18838598 |
| Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces. |
2987648 |
| Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA. |
19369248 |
| Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA. |
7925357 |
| Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. |
20194115 |
| Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis. |
1447159 |
| Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm. |
18586937 |
| Crystallization and preliminary crystallographic analysis of nosiheptide-resistance methyltransferase from Streptomyces actuosus in complex with SAM. |
20445264 |
| Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5. |
18384044 |
| Reliable Chemical Synthesis of Oligoribonucleotides (RNA) with 2′-O-[(Triisopropylsilyl)oxy]methyl(2′-O-tom)-Protected Phosphoramidites |
10.1002/1522-2675(20011219)84:12<3773::AID-HLCA377 |
| The use of labilebaseprotectinggroups in oligoribonucleotidesynthesis |
10.1016/S0040-4039(01)80326-9 |
| Methylaminedeprotectionprovidesincreasedyield of oligoribonucleotides |
10.1016/0040-4039(95)01953-F |
| The Synthesis of Allyl- and Ailyioxycarbonyl-Protected RNA Phosphoramidites. Useful Reagents for Solid-Phase Synthesis of RNAs with Base-Labile Modifications |
10.1016/S0040-4039(98)00157-9 |
| 2′-O-Methyl Thiomethyl Modifications in Hammerhead Ribozymes |
10.1080/07328319708006114 |
| Ultrafast Cleavage and Deprotection of Oligonucleotides Synthesis and Use of CAc Derivatives |
10.1080/07328319708006236 |
| Ein neuer Zugang zu 2’-O-Alkylribonucleosiden und Eigenschaften deren Oligonucleotide |
10.1002/hlca.19950780219 |
| A Facile Synthesis of the Phosphoramidites of 2-N-Methyl-2′- deoxy (or 2′-O-allyl)-ψ-isocytidine, 1, 3-Dimethyl-2′-deoxy-ψ-uridine and N1- Methyl-2′-O-allyl-ψ-uridine as Synthons Suitable for Oligonuc |
10.1080/15257779408009476 |
| A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group. |
16048321 |
| Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies. |
12723951 |
| Synthesis and properties of 2'-O-methyl-2-thiouridine and oligoribonucleotides containing 2'-O-methyl-2-thiouridine. |
10969970 |
| Synthesis of modified nucleosides for the incorporation into tRNAs |
|
| Chemical Approach for the Study of the ‘Kissing Complex’ of Moloney murine leukaemia Virus |
10.1002/hlca.200890133 |
| The methylthiolation reaction mediated by the Radical-SAM enzymes. |
22178611 |
| Identification of Aquifex aeolicus tRNA (m2(2G26) methyltransferase gene. |
12903189 |
| Fluorescent properties of an unnatural nucleobase, 2-amino-6-(2-thienyl)purine, in DNA and RNA fragments. |
17150745 |
| Aquifex aeolicus Trm1[tRNA (m2(2)G26) methyltransferase] has a novel recognition mechanism of the substrate RNA. |
17150754 |
| RNA nucleotide methylation. |
21823225 |
| The Handling of the Mechanistic Probe 5-Fluorouridine by the Pseudouridine Synthase TruA and Its Consistency with the Handling of the Same Probe by the Pseudouridine Synthases TruB and RluA. |
21142053 |
| Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli. |
15136037 |
| Structural Basis of Biological Nitrile Reduction. |
22787148 |
| Structural mechanism of substrate RNA recruitment in H/ACA RNA-guided pseudouridine synthase. |
19481523 |
| cAMP-dependent transcription of the human CYP21B (P-450C21) gene requires a cis-regulatory element distinct from the consensus cAMP-regulatory element. |
2162843 |
| Identification of determinants in the protein partners aCBF5 and aNOP10 necessary for the tRNA:Psi55-synthase and RNA-guided RNA:Psi-synthase activities. |
17704128 |
| Differential roles of archaeal box H/ACA proteins in guide RNA-dependent and independent pseudouridine formation. |
17993784 |
| Pseudouridine formation in archaeal RNAs: The case of Haloferax volcanii. |
21628430 |
| Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. |
21829385 |
| Expanding role of the jumonji C domain as an RNA hydroxylase. |
20739293 |
| Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. |
20972222 |
| The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. |
22085966 |
| Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human. |
15671491 |
| An essential function of Saccharomyces cerevisiae RNA triphosphatase Cet1 is to stabilize RNA guanylyltransferase Ceg1 against thermal inactivation. |
11463793 |
| Molecular evolution of dihydrouridine synthases. |
22741570 |
| Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. |
19139092 |
| Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. |
21912530 |
| Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. |
10024884 |
| Intrinsic resistance to aminoglycosides in Enterococcus faecium is conferred by the 16S rRNA m5C1404-specific methyltransferase EfmM. |
21159796 |
| N6-adenosine methylation in mRNA: substrate specificity and enzyme complexity. |
7748945 |
| Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells. |
11470232 |
| Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. |
9409616 |
| Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. |
10430867 |
| The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene. |
10982862 |
| Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA). |
17071714 |
| Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA. |
22344696 |
| Function and detection of 5-methylcytosine in eukaryotic RNA. |
22122054 |
| Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. |
16424344 |
| Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. |
11139614 |
| The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy. |
22891362 |
| A novel minimum ribozyme with oxidoreduction activity. |
2271669 |
| Synthesis, base pairing properties and trans-lesion synthesis by reverse transcriptases of oligoribonucleotides containing the oxidatively damaged base 5-hydroxycytidine. |
21852326 |
| Discovery and biological characterization of geranylated RNA in bacteria. |
22983156 |
| A gain of function mutation in a protein mediates production of novel modified nucleosides. |
15861125 |
| Escherichia coli mutant SELD enzymes. The cysteine 17 residue is essential for selenophosphate formation from ATP and selenide. |
1527085 |
| Selenophosphate synthetase. Enzyme properties and catalytic reaction. |
8144648 |
| Biosynthesis of selenophosphate. |
10609888 |
| A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation. |
12370316 |
| Characterization and structure of the Aquifex aeolicus protein DUF752: a bacterial tRNA-methyltransferase (MnmC2) functioning without the usually fused oxidase domain (MnmC1). |
23091054 |
| Covalent Intermediate in the Catalytic Mechanism of the Radical S-Adenosyl-l-methionine Methyl Synthase RlmN Trapped by Mutagenesis. |
23088750 |
| The Human tRNA m ( 5) C methyltransferase Misu is multisite-specific. |
22995836 |
| Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing. |
23063121 |
| FAD/Folate-Dependent tRNA Methyltransferase: Flavin as a new methyl-transfer agent. |
23157377 |
| Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2. |
10864042 |
| The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. |
17612558 |
| RNA methylation by the MIS complex regulates a cell fate decision in yeast. |
22685417 |
| SufA/IscA: reactivity studies of a class of scaffold proteins involved in [Fe-S] cluster assembly. |
15278785 |
| Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation. |
16585765 |
| Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. |
8978773 |
| Biogenesis and intranuclear trafficking of human box C/D and H/ACA RNPs. |
17381323 |
| Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae. |
15220327 |
| Isd11p protein activates the mitochondrial cysteine desulfurase Nfs1p protein. |
21908622 |
| Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface. |
21708174 |
| Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. |
23180764 |
| The tRNA recognition mechanism of folate/FAD-dependent tRNA methyltransferase (TrmFO). |
23095745 |
| Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. |
22912484 |
| ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. |
23177736 |
| Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF-1alpha). |
21264265 |
| Trm13p, the tRNA:Xm4 modification enzyme from Saccharomyces cerevisiae is a member of the Rossmann-fold MTase superfamily: prediction of structure and active site. |
19697067 |
| Over expression of a tRNA(Leu) isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading. |
16236318 |
| 15N-labeled tRNA. Identification of 4-thiouridine in Escherichia coli tRNASer1 and tRNATyr2 by 1H-15N two-dimensional NMR spectroscopy. |
3638307 |
| Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. |
22362751 |
| The isolation and characterization of N-[9-(beta-D-ribofuranosyl)-purin-6-ylcarbamoyl]glycine from yeast transfer RNA. |
5503779 |
| Pseudouridine modification in Caenorhabditis elegans spliceosomal snRNAs: unique modifications are found in regions involved in snRNA-snRNA interactions. |
16236171 |
| Pseudouridylation goes regulatory. |
21206510 |
| U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP. |
21131909 |
| Caenorhabditis elegans pseudouridine synthase 1 activity in vivo: tRNA is a substrate, but not U2 small nuclear RNA. |
12597772 |
| Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. |
23097428 |
| A cyclic form of N(6)-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification. |
23242255 |
| A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. |
23042678 |
| Pseudouridine at position 55 in tRNA controls the contents of other modified nucleotides for low-temperature adaptation in the extreme-thermophilic eubacterium Thermus thermophilus. |
21097467 |
| Identification and characterization of the Thermus thermophilus 5-methylcytidine (m5C) methyltransferase modifying 23 S ribosomal RNA (rRNA) base C1942. |
22711535 |
| Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics. |
19589804 |
| Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine. |
16511182 |
| Emerging themes in radical SAM chemistry. |
23141873 |
| The last rRNA methyltransferase of E. coli revealed: the yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA. |
22847818 |
| Characterization of a B. subtilis minor isoleucine tRNA deduced from tDNA having a methionine anticodon CAT. |
8743586 |
| Characterization of a whole set of tRNA molecules in an aerobic hyper-thermophilic Crenarchaeon, Aeropyrum pernix K1. |
16769697 |
| The complete set of tRNA species in Nanoarchaeum equitans. |
15893316 |
| Loss of a universal tRNA feature. |
17172343 |
| Mitochondrial tRNA import in Toxoplasma gondii. |
15280394 |
| Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae |
23558746 |
| Mechanistic insights into small RNA recognition and modification by the HEN1 methyltransferase. |
23621770 |
| FTO-mediated formation of N(6)-hydroxymethyladenosine and N(6)-formyladenosine in mammalian RNA. |
23653210 |
| N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. |
22002720 |
| Crystal structure of the FTO protein reveals basis for its substrate specificity. |
20376003 |
| Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. |
23676670 |
| S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. |
23695253 |
| The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome. |
23542153 |
| tRNA binding, positioning and modification by the pseudouridine synthase Pus10. |
23743107 |
| The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL. |
23804755 |
| Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10. |
23793893 |
| Conservation of structure and mechanism by Trm5 enzymes. |
23887145 |
| Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs. |
11918670 |
| Substrate recognition of tRNA (Guanosine-2'-)-methyltransferase from Thermus thermophilus HB27. |
9748240 |
| Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme. |
15062082 |
| The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and non-substrate tRNA via an induced-fit process. |
23867454 |
| Structure of dihydrouridine synthase C (DusC) from Escherichia coli. |
23908023 |
| Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. |
23913415 |
| The methyltransferase adaptor protein Trm112 is involved in biogenesis of both ribosomal subunits. |
22956767 |
| Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ. |
23945937 |
| Influence of temperature on tRNA modification in archaea: Methanococcoides burtonii (optimum growth temperature [Topt], 23 degrees C) and Stetteria hydrogenophila (Topt, 95 degrees C). |
12949100 |
| Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate |
24081582 |
| Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA. |
22761755 |
| A small RNA derived from RNA coactivator SRA blocks steroid receptor signaling via inhibition of Pus1p-mediated pseudouridylation of SRA: evidence of a novel RNA binding domain in the N-terminus of steroid receptors. |
22998747 |
| Pseudouridine synthase 1: a site-specific synthase without strict sequence recognition requirements. |
22102571 |
| Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1. |
18648068 |
| Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. |
15772074 |
| In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. |
23707380 |
| The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA. |
9512533 |
| Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. |
12456664 |
| Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. |
15893315 |
| Effect of a mutation in the anticodon of human mitochondrial tRNAPro on its post-transcriptional modification pattern. |
9421512 |
| Tertiary network in mammalian mitochondrial tRNAAsp revealed by solution probing and phylogeny. |
19767615 |
| Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. |
16446307 |
| A disease-causing point mutation in human mitochondrial tRNAMet rsults in tRNA misfolding leading to defects in translational initiation and elongation. |
18835817 |
| Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. |
23617613 |
| Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. |
22760636 |
| A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation. |
24316715 |
| Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. |
24344322 |
| Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae. |
24335083 |
| An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation. |
24371284 |
| The output of the tRNA modification pathways controlled by the Escherichia coli MnmEG and MnmC enzymes depends on the growth conditions and the tRNA species. |
24293650 |
| Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. |
24489119 |
| Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification. |
24586927 |
| Crystal Structures of Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition. |
24616105 |
| Molecular biology. Internal mRNA methylation finally finds functions. |
24626918 |
| SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization. |
24634441 |
| Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. |
24717845 |
| Initiator tRNAs from archaebacteria show common unique sequence characteristics. |
6178978 |
| Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. |
24141618 |
| Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single stranded m6A RNA demethylation. |
24778178 |
| Distinct tRNA modifications in the thermo-acidophilic archaeon, Thermoplasma acidophilum. |
24076028 |
| Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine. |
23856057 |
| Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine. |
22026549 |
| 4-Demethylwyosine synthase from Pyrococcus abyssi is a radical-S-adenosyl-L-methionine enzyme with an additional [4Fe-4S](+2) cluster that interacts with the pyruvate co-substrate. |
23043105 |
| A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs. |
24831542 |
| Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. |
19805282 |
| A novel cloverleaf structure found in mammalian mitochondrial tRNA(Ser) (UCN). |
1840673 |
| Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase. |
17470432 |
| Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA. |
20129918 |
| Mechanism of N6-threonylcarbamoyladenonsine (t(6)A) biosynthesis: isolation and characterization of the intermediate threonylcarbamoyl-AMP. |
23072323 |
| Yeast serine isoacceptor tRNAs: variations of their content as a function of growth conditions and primary structure of the minor tRNA(Ser)GCU. |
8033992 |
| N6-Acetyladenosine: a new modified nucleoside from Methanopyrus kandleri tRNA. |
15907485 |
| The flavoprotein Mcap0476 (RlmFO) catalyzes m5U1939 modification in Mycoplasma capricolum 23S rRNA. |
24939895 |
| Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates. |
24951554 |
| The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. |
24711368 |
| TtcA a new tRNA-thioltransferase with an Fe-S cluster. |
24914049 |
| TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. |
25053765 |
| A single acetylation of 18S rRNA is essential for biogenesis of the small ribosomal subunit in Saccharomyces cerevisiae. |
25086048 |
| Binding Induced RNA Conformational Changes Control Substrate Recognition and Catalysis by the Thiostrepton-resistance Methyltransferase (Tsr). |
25086036 |
| Assignment of 2'-O-methyltransferases to Modification Sites on the Mammalian Mitochondrial Large Subunit 16S rRNA. |
25074936 |
| Discovery of the beta-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. |
25063302 |
| Biosynthesis of wyosine derivatives in tRNA(Phe) of Archaea: role of a remarkable bifunctional tRNA(Phe):m1G/imG2 methyltransferase. |
24837075 |
| A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability. |
25125595 |
| Trm4 and Nsun2 RNA:mC Methyltransferases Form Metabolite-Dependent, Covalent Adducts with Previously Methylated RNA. |
25375641 |
| Methylation by NSun2 represses the levels and function of microRNA 125b. |
25047833 |
| Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP. |
25084372 |
| Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes. |
25489090 |
| Hypermethylated-capped selenoprotein mRNAs in mammals. |
25013170 |
| FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. |
25412662 |
| Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA. |
22561317 |
| Purification, crystallization and preliminary crystallographic analysis of the 16S rRNA methyltransferase RsmI from Escherichia coli. |
25195904 |
| Dynamics of RNA modification by a multi-site-specific tRNA methyltransferase. |
25217588 |
| Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. |
20483913 |
| Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18S rRNA. |
25411247 |
| RNA Cytidine Acetyltransferase of Small-Subunit Ribosomal RNA: Identification of Acetylation Sites and the Responsible Acetyltransferase in Fission Yeast, Schizosaccharomyces pombe. |
25402480 |
| Steroid receptor RNA activator (SRA) modification by the human pseudouridine synthase 1 (hPus1p): RNA binding, activity, and atomic model. |
24722331 |
| Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2. |
25543256 |
| Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module. |
15952786 |
| Structure determination of two new amino acid-containing derivatives of adenosine from tRNA of thermophilic bacteria and archaea. |
1280806 |
| Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. |
25635753 |
| Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. |
25653167 |
| Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast. |
1468572 |
| Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. |
25404562 |
| Intron-dependent formation of pseudouridines in the anticodon of Saccharomyces cerevisiae minor tRNA(Ile). |
7925304 |
| Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. |
25855808 |
| Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures. |
25870413 |
| Eukaryotic wobble uridine modifications promote a functionally redundant decoding system. |
18332122 |
| Selenium-containing tRNA(Glu) and tRNA(Lys) from Escherichia coli: purification, codon specificity and translational activity. |
2679651 |
| The Structure of Escherichia coli TcdA (Also Known As CsdL) Reveals a Novel Topology and Provides Insight into the tRNA Binding Surface Required for N-Threonylcarbamoyladenosine Dehydratase Activity. |
26101842 |
| The crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily. |
25897750 |
| An extended dsRBD is required for post-transcriptional modification in human tRNAs. |
26429968 |
| Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism. |
26416026 |
| Crystal Structure of the Human tRNA mA58 Methyltransferase-tRNA Complex: Refolding of Substrate tRNA allows Access to the Methylation Target. |
26470919 |
| Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure. |
26438534 |
| A map of 5-methylcytosine residues in Trypanosoma brucei tRNA revealed by sodium bisulfite sequencing. |
24389163 |
| Biogenesis and growth phase-dependent alteration of 5-methoxycarbonylmethoxyuridine in tRNA anticodons |
26681692 |
| Multisite-specific archaeosine tRNA-guanine transglycosylase (ArcTGT) from Thermoplasma acidophilum, a thermo-acidophilic archaeon. |
26721388 |
| Substrate Recognition and Modification by the Nosiheptide Resistance Methyltransferase |
4409310 |
| Substrate tRNA recognition mechanism of eubacterial tRNA (m1A58) methyltransferase (TrmI). |
25593312 |
| Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. |
22832247 |
| An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis |
26516084 |
| Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine. |
26424849 |
| Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity. |
26492405 |
| Profiling of RNA modifications by multiplexed stable isotope labelling. |
24567952 |
| Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. |
24625781 |
| Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. |
25129236 |
| The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention |
28525753 |
| NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. |
26160102 |
| Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6. |
27703015 |
| Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. |
28531330 |
| Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. |
28655767 |
| NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly. |
24516400 |
| Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. |
22949673 |
| MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. |
21531335 |
| A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. |
11809803 |
| Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. |
19356719 |
| MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. |
25009282 |
| The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules. |
28082677 |
| A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. |
27974379 |
| NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met). |
27214402 |
| Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. |
27356879 |
| NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. |
27497299 |
| Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. |
20354154 |
| A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition. |
27055666 |
| Identification of the methyltransferase targeting C2499 in Deinococcus radiodurans 23S ribosomal RNA. |
26590840 |
| MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. |
18505803 |
| Identification of factors required for m(6) A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI. |
28503769 |
| Unique Features of the m6A Methylome in Arabidopsis thaliana |
25430002 |
| Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAs |
5389704 |
| Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases |
26700482 |
| Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue. |
26673726 |
| Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation |
26670883 |
| RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithr |
26365244 |
| tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily. |
26202969 |
| Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase. |
26106808 |
| The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. |
25851604 |
| Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria. |
28783151 |
| A vastly increased chemical variety of RNA modifications that includes a thioacetal structure |
29624844 |
| ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications. |
28472312 |
| Purification and characterization of the human elongator complex. |
11714725 |
| A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. |
19017811 |
| Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. |
29628141 |
| A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. |
26888608 |
| RNA editing by adenosine deaminases generates RNA and protein diversity. |
12457566 |
| A splice site mutation in the methyltransferase gene FTSJ1 in Xp11.23 is associated with non-syndromic mental retardation in a large Belgian family (MRX9). |
15342698 |
| Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation. |
15162322 |
| Solution structure of Urm1 and its implications for the origin of protein modifiers. |
16864801 |
| Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. |
15910006 |
| Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. |
16847322 |
| Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. |
11060020 |
| Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. |
27903914 |
| The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. |
22912744 |
| tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy. |
28272532 |
| Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency. |
12914926 |
| Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. |
11546806 |
| Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein. |
12659830 |
| 2'-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA. |
28107630 |
| Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. |
29982645 |
| LC/MS analysis and deep sequencing reveal the accurate RNA composition in the HIV-1 virion. |
31213632 |
| RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. |
11001933 |
| Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acutemyeloid leukemia cell proliferation. |
32097467 |
| Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. |
23001123 |
| The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. |
32017898 |
| FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. |
29501742 |
| The obesity related gene, FTO, interacts with APOE, and is associated withAlzheimer's disease risk: a prospective cohort study. |
21098976 |
| Genetic variants in the Fat and Obesity Associated (FTO) gene and risk ofAlzheimer's disease. |
23251365 |
| Abnormality of m6A mRNA Methylation Is Involved in Alzheimer's Disease. |
32184705 |
| Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. |
11717408 |
| Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for newtherapeutic targets? |
25531686 |
| Association between obesity-related gene FTO and ADHD. |
23512716 |
| Control of human potassium channel inactivation by editing of a small mRNA hairpin. |
15361858 |
| METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner. |
31228940 |
| The mA methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network. |
30659266 |
| Dynamic mA mRNA methylation reveals the role of METTL3-mA-CDCP1 signaling axis in chemical carcinogenesis. |
30796352 |
| Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N-methyladenosine of Notch1. |
31760940 |
| Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation. |
32281240 |
| A commonly carried allele of the obesity-related FTO gene is associated with reducedbrain volume in the healthy elderly. |
20404173 |
| Topological Characterization of Human and Mouse mC Epitranscriptome Revealed by Bisulfite Sequencing. |
30009162 |
| Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. |
26440892 |
| p53 acts as a safeguard of translational control by regulating fibrillarin and rRNAmethylation in cancer. |
24029231 |
| HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancervia inhibiting tumor suppressor let-7g. |
29174803 |
| N-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression. |
30131850 |
| Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA. |
27001847 |
| Changes of N6-methyladenosine modulators promote breast cancer progression. |
30953473 |
| RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3. |
30922314 |
| HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells. |
31263129 |
| N6-methyladenosine-related Genomic Targets are Altered in Breast Cancer Tissue and Associated with Poor Survival. |
31632489 |
| N6-methyladenosine METTL3 promotes the breast cancer progression via targetingBcl-2. |
31454538 |
| Transfer RNA demethylase ALKBH3 promotes cancer progression via induction oftRNA-derived small RNAs. |
30541109 |
| RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure |
30087110 |
| Genetic associations and regulation of expression indicate an independent role for14q32 snoRNAs in human cardiovascular disease. |
30544252 |
| FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation. |
29315835 |
| The mA eraser FTO facilitates proliferation and migration of human cervical cancer cells. |
31827395 |
| Reduced mA mRNA methylation is correlated with the progression of human cervical cancer. |
29228737 |
| A-to-I RNA editing of BLCAP lost the inhibition to STAT3 activation in cervicalcancer. |
28455960 |
| ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. |
23275297 |
| mA methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways. |
31239708 |
| METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-DependentPrimary miR-375 Processing. |
31839484 |
| METTL3 facilitates tumor progression via an mA-IGF2BP2-dependent mechanism in colorectal carcinoma. |
31230592 |
| Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. |
29484125 |
| YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma. |
31131257 |
| mA-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1. |
30979372 |
| Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway. |
31492150 |
| RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiencyby which HIF-1α mRNA is translated. |
26996300 |
| RNA editing in RHOQ promotes invasion potential in colorectal cancer. |
24663214 |
| Alternative splicing and extensive RNA editing of human TPH2 transcripts. |
20126463 |
| RNA editing of apolipoprotein B mRNA. Sequence specificity determined by in vitrocoupled transcription editing. |
2324099 |
| Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome. |
22577224 |
| Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita. |
31570891 |
| mA mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. |
30154548 |
| RNA editing of drives early tumor invasion and metastasis in familial esophageal cancer. |
28533408 |
| A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. |
23766440 |
| ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma. |
28035363 |
| Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF inesophageal squamous cell carcinoma. |
29763634 |
| ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1. |
31290116 |
| METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells. |
30886897 |
| Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. |
31232471 |
| FTO expression is associated with the occurrence of gastric cancer and prognosis. |
28849183 |
| Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer. |
30637548 |
| [Knockdown of YTH N(6)-methyladenosine RNA binding protein 2 (YTHDF2) inhibitsproliferation and promotes apoptosis in MGC-803 gastric cancer cells]. |
29382422 |
| Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer. |
31243897 |
| m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in GastrointestinalCancer. |
31352195 |
| m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells bySustaining FOXM1 Expression and Cell Proliferation Program. |
28344040 |
| FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. |
25832656 |
| m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of GlioblastomaStem Cells. |
28297667 |
| N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for theExpression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling |
30781903 |
| Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. |
28991227 |
| Expression and roles of Wilms' tumor 1-associating protein in glioblastoma. |
22957919 |
| WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients. |
27370540 |
| TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. |
26234676 |
| Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma. |
30760294 |
| Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. |
25582055 |
| High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis inHead and Neck Squamous Carcinoma. |
29775108 |
| Hypermethylation of 28S ribosomal RNA in β-thalassemia trait carriers. |
27765567 |
| RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. |
29171881 |
| Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets. |
31118805 |
| RNA mA methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. |
31061416 |
| METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N -methyladenosine-dependent primary MicroRNA processing. |
27774652 |
| MicroRNA-145 Modulates -Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the -Methyladenosine Binding YTH Domain Family 2 Protein. |
28104805 |
| YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma. |
31735169 |
| YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA inhepatocellular carcinoma. |
30423408 |
| Overexpression of YTHDF1 is associated with poor prognosis in patients withhepatocellular carcinoma. |
29439311 |
| KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA. |
31118692 |
| KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3. |
31856849 |
| WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. |
31438961 |
| M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. |
31915027 |
| CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients. |
29996118 |
| Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma. |
24302582 |
| Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. |
23291631 |
| A novel translational repressor mRNA is edited extensively in livers containingtumors caused by the transgene expression of the apoB mRNA-editing enzyme. |
9030685 |
| Transcriptome-wide map of mA circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension. |
31931709 |
| Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly,Short Stature, and Aggressive Behavior. |
30526862 |
| Inactivation of the Fto gene protects from obesity. |
19234441 |
| Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. |
28398475 |
| PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly. |
30778726 |
| METTL3 and ALKBH5 oppositely regulate mA modification of mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes. |
30870073 |
| AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia. |
28650479 |
| The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1-positive acute lymphoblastic leukemia. |
31429529 |
| Genetic alterations of mA regulators predict poorer survival in acute myeloid leukemia. |
28153030 |
| The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. |
28920958 |
| FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNADemethylase. |
28017614 |
| Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells inAcute Myeloid Leukemia. |
31031138 |
| Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. |
30991027 |
| Suppression of mA reader Ythdf2 promotes hematopoietic stem cell expansion. |
30065315 |
| METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and PromotesLeukemogenesis via mRNA m(6)A Modification. |
29290617 |
| Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry. |
26707930 |
| Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. |
26640150 |
| An association study of the m6A genes with major depressive disorder in Chinese Hanpopulation. |
26047305 |
| The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. |
23164817 |
| The effect of FTO rs9939609 on major depression differs across MDD subtypes. |
24492350 |
| The Association Between the FTO rs9939609 Variant and Malignant Pleural Mesothelioma Risk: A Case-Control Study. |
29260910 |
| mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. |
31239444 |
| RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrixmetallopeptidase 2. |
30762711 |
| mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation. |
31722709 |
| Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report. |
31027506 |
| Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathyand sideroblastic anemia (MLASA). |
15108122 |
| Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. |
29203771 |
| RNA modification landscape of the human mitochondrial tRNA regulates protein synthesis. |
30262910 |
| Pseudouridine Modification Inhibits Muscleblind-like 1 (MBNL1) Binding to CCUG Repeats and Minimally Structured RNA through Reduced RNA Flexibility. |
28130447 |
| Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders. |
25063673 |
| C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both thetype II transcript and apobec-1, the catalytic subunit of the apolipoprotein BmRNA-editing enzyme. |
11727199 |
| The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. |
27117702 |
| MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. |
27856248 |
| mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. |
30232453 |
| mA mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis. |
31818312 |
| N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1. |
31823788 |
| The m6A demethylase FTO promotes the growth of lung cancer cells by regulating them6A level of USP7 mRNA. |
30905413 |
| m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinomaby regulating MZF1 expression. |
29842885 |
| YTH domain family 2 promotes lung cancer cell growth by facilitating6-phosphogluconate dehydrogenase mRNA translation. |
31504235 |
| ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lungadenocarcinoma cells under intermittent hypoxia. |
31677788 |
| N(6)-methyladenosine ALKBH5 promotes non-small cell lung cancer progress byregulating TIMP3 stability. |
31927006 |
| Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. |
26310293 |
| Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. |
18647953 |
| FTO haplotyping underlines high obesity risk for European populations. |
30871540 |
| Genome-wide association scan shows genetic variants in the FTO gene are associatedwith obesity-related traits. |
17658951 |
| Mettl3-mediated mA RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. |
30429466 |
| The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating them6A level of LEF1. |
31253399 |
| Human ALKBH3-induced m(1)A demethylation increases the CSF-1 mRNA stability inbreast and ovarian cancer cells. |
30342176 |
| The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells. |
29345285 |
| YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. |
29135329 |
| Germline copy number variation in the YTHDC2 gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcinoma susceptibility? |
24834797 |
| ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation. |
30032148 |
| mA demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling. |
31906946 |
| Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. |
30835997 |
| Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. |
27907896 |
| Increased N6-methyladenosine causes infertility is associated with FTO expression. |
29384212 |
| Downregulation of N-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N-methyladenosine levels. |
29423080 |
| RNA mA Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway. |
31806999 |
| Quantitative analysis of 5HT(2C) receptor RNA editing patterns in psychiatric disorders. |
21914481 |
| The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma. |
29221190 |
| The mA-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. |
31159832 |
| N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. |
30648791 |
| Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability. |
29482572 |
| APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts. |
25807502 |
| Early-onset epilepsy and postnatal lethality associated with an editing-deficientGluR-B allele in mice. |
7502080 |
| Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. |
20456005 |
| A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy. |
29375302 |
| The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNAmethylation. |
15930015 |
| A common variant in the FTO gene is associated with body mass index and predisposesto childhood and adult obesity. |
17434869 |
| mA mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes. |
31867565 |
| Global analysis of A-to-I RNA editing reveals association with common disease variants. |
29527417 |
| 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs |
31358969 |
| Cap-specific terminal -methylation of RNA by an RNA polymerase II-associated methyltransferase. |
30467178 |
| Cap-specific, terminal N-methylation by a mammalian mAm methyltransferase. |
30487554 |
| Identification of the mAm Methyltransferase PCIF1 Reveals the Location and Functions of mAm in the Transcriptome. |
31279658 |
| PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. |
31279659 |
| The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. |
31328227 |
| The rRNA mA methyltransferase METTL5 is involved in pluripotency and developmental programs. |
32217665 |
| NMethyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. |
30531910 |
| The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. |
31799605 |
| Structure and regulation of ZCCHC4 in mA-methylation of 28S rRNA. |
31695039 |
| METTL4 is an snRNA mAm methyltransferase that regulates RNA splicing. |
31913360 |
| N-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA. |
32183942 |
| Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast. |
30646830 |
| Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. |
23074192 |
| Chloroplast development at low temperatures requires a homolog of DIM1, a yeast gene encoding the 18S rRNA dimethylase. |
9596631 |
| RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms. |
20722735 |
| Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. |
31594862 |
| Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance. |
31601908 |
| ErmE methyltransferase recognizes features of the primary and secondary structure in a motif within domain V of 23 S rRNA. |
9973557 |
| Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase. |
7961464 |
| The conformation of 23S rRNA nucleotide A2058 determines its recognition by the ErmE methyltransferase. |
7489511 |
| FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA. |
31361898 |
| mU54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs. |
33799331 |
| TRMT2B is responsible for both tRNA and rRNA mU-methylation in human mitochondria. |
31948311 |
| Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for mU formation in both tRNA and rRNA. |
31736397 |
| Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae. |
34076597 |
| The critical function of the plastid rRNA methyltransferase, CMAL, in ribosome biogenesis and plant development. |
32095829 |
| METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. |
31665743 |
| The human mitochondrial 12S rRNA mC methyltransferase METTL15 is required for mitochondrial function. |
32371392 |
| METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. |
32573735 |
| A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. |
27667664 |
| Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA. |
33023933 |
| TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code. |
28073919 |
| Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6. |
34268557 |
| Cytosine-5 RNA methylation links protein synthesis to cell metabolism. |
31199786 |
| The tRNA methyltransferase NSun2 stabilizes p16INK⁴ mRNA by methylating the 3'-untranslated region of p16. |
22395603 |
| Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation. |
31186410 |
| Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. |
31819270 |
| The human ortholog of archaeal Pus10 produces pseudouridine 54 in select tRNAs where its recognition sequence contains a modified residue. |
30530625 |
| Functional organization of box C/D RNA-guided RNA methyltransferase. |
32297938 |
| Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. |
31251801 |
| Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates. |
27631568 |
| Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B. |
31292261 |
| Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability. |
33771871 |
| 1 METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs |
https://www.biorxiv.org/content/10.1101/2021.05.02 |
| Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. |
15140959 |
| Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. |
33232691 |
| Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. |
34198328 |
| Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. |
33956156 |
| A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex. |
33874769 |
| Functional characterization of the mammalian mRNA decapping enzyme hDcp2. |
12923261 |
| Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |
12486012 |
| Multiple mRNA decapping enzymes in mammalian cells. |
21070968 |
| The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes |
28628654 |
| Local cerebral glucose consumption during ethanol withdrawal in the rat: effects of single and multiple episodes and previous convulsive seizures. |
3401759 |
| The crystal structure of the lysyl-tRNA synthetase (LysU) from Escherichia coli. |
7735833 |
| Stresses that Raise NpA Levels Induce Protective Nucleoside Tetraphosphate Capping of Bacterial RNA. |
31178354 |
| Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. |
33139726 |
| "NAD-capQ" detection and quantitation of NAD caps. |
30045887 |
| Identification of a quality-control mechanism for mRNA 5'-end capping. |
20802481 |
| The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes. |
11361135 |
| 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. |
28283058 |
| Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. |
31101919 |
| 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO |
29601584 |
| Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin. |
32709887 |
| High-resolution structures of the SARS-CoV-2 2'--methyltransferase reveal strategies for structure-based inhibitor design. |
32994211 |
| Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. |
29484125 |
| YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma |
31131257 |
| METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells |
30886897 |
| Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. |
31232471 |
| FTO expression is associated with the occurrence of gastric cancer and prognosis. |
28849183 |
| Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer. |
30637548 |
| N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. |
30781903 |
| Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. |
28991227 |
| Expression and roles of Wilms' tumor 1-associating protein in glioblastoma. |
22957919 |
| WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients. |
27370540 |
| Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma |
29439311 |
| Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets |
31118805 |
| The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. |
23164817 |
| The effect of FTO rs9939609 on major depression differs across MDD subtypes. |
24492350 |
| Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues. |
32571340 |
| NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation. |
34504059 |
| The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation. |
33418496 |
| N1-methyladenosine profiling of long non-coding RNA in colorectal cancer. |
34314547 |
| Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome. |
32915956 |
| Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease |
26655226 |
| Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing |
7972084 |
| Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis |
10589532 |
| Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons |
22226999 |
| Altered Editing of Serotonin 2C Receptor Pre-mRNA in the Prefrontal Cortex of Depressed Suicide Victims |
11988167 |
| Mutations of the RNA-Specific Adenosine Deaminase Gene (DSRAD) Are Involved in Dyschromatosis Symmetrica Hereditaria |
12916015 |
| Altered adenosine-to-inosine RNA editing in human cancer |
17908822 |
| AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders |
31300657 |
| RNA editing of the 5-HT2C receptor is reduced in schizophrenia |
11443520 |
| Region-specific alterations of A-to-I RNA editing of serotonin 2c receptor in the cortex of suicides with major depression |
27576167 |
| Increased adenosine-to-inosine RNA editing in rheumatoid arthritis |
31493964 |
| Human BLCAP transcript: new editing events in normal andcancerous tissues |
19908260 |
| Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes |
18462347 |
| RNA editing (R/G site) and flip–flop splicing of the AMPA receptorsubunit GluR2 in nervous tissue of epilepsy patients |
15006707 |
| The Neurofibromatosis Type I Messenger RNA Undergoes Base-Modification RNA Editing |
8602361 |
| The ADAR protein family |
23273215 |
| Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. |
29234087 |
| Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase. |
16600901 |
| Crystal Structure of Glutamyl-Queuosine Trnaasp Synthetase Complexed with L-Glutamate: Structural Elements Mediating tRNA-Independent Activation of Glutamate and Glutamylation of Trnaasp Anticodon. |
18602926 |
| Structural organization of box C/D RNA-guided RNA methyltransferase. |
19666563 |
| Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. |
32159918 |
| Mechanism of 5' splice site transfer for human spliceosome activation. |
30975767 |
| Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2. |
30605527 |
| Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. |
32432673 |
| The Structure of Escherichia coli TcdA (Also Known As CsdL) Reveals a Novel Topology and Provides Insight into the tRNA Binding Surface Required for N(6)-Threonylcarbamoyladenosine Dehydratase Activity. |
26101842 |
| Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA |
18068186 |
| Domain Organization and Crystal Structure of the Catalytic Domain of E.coli RluF, a Pseudouridine Synthase that Acts on 23S rRNA |
16712869 |
| Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. |
30467178 |
| The structure of the TrmE GTP-binding protein and its implications for tRNA modification |
15616586 |
| Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants. |
17631273 |
| Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. |
26470919 |
| Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. |
24778178 |
| Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. |
25412658 |
| Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. |
21784869 |
| The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding. |
11206077 |
| Structure and function of archaeal box C/D sRNP core proteins. |
12598892 |
| Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 |
19717466 |
| Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. |
31594862 |
| Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate |
12949492 |
| Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. |
25735745 |
| The Yeast Ribosome Synthesis Factor Emg1 is a Novel Member of the Superfamily of Alpha/Beta Knot Fold Methyltransferases. |
18063569 |
| Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG |
19622680 |
| Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG |
19622680 |
| Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. |
32526208 |
| Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates. |
24951554 |
| Alternate rRNA secondary structures as regulators of translation |
21217697 |
| The First Structure of an RNA m5C Methyltransferase, Fmu, Provides Insight into Catalytic Mechanism and Specific Binding of RNA Substrate |
14656444 |
| Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. |
20639535 |
| Structural basis of prokaryotic NAD-RNA decapping by NudC |
27561816 |
| Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1. |
30149595 |
| The Structure of the Box C/D Enzyme Reveals Regulation of RNA Methylation. |
24121435 |
| Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. |
15769464 |
| New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. |
33475202 |
| Steroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model |
24722331 |
| Structural basis of tRNA agmatinylation essential for AUA codon decoding |
22002223 |
| Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. |
17189261 |
| Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase |
22085967 |
| Crystal Structure of the Spliceosomal 15.5Kd Protein Bound to a U4 Snrna Fragment |
11163207 |
| Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases |
19303884 |
| The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism. |
29290613 |
| Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. |
19285505 |
| Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. |
24081582 |
| Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. |
19822745 |
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA |
19478803 |
| Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes |
25489090 |
| Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP. |
11953756 |
| Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. |
18451029 |
| Deep Knot Structure for Construction of Active Site and Cofactor Binding Site of tRNA Modification Enzyme |
15062082 |
| Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. |
20163168 |
| Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. |
33902106 |
| Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes |
15581897 |
| Crystal structure of a junction between two Z-DNA helices. |
20439751 |
| Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation. |
28575276 |
| Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold. |
12001236 |
| Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. |
25855808 |
| Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. |
18849968 |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
20558545 |
| Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme. |
11779468 |
| Structural basis for methyl transfer by a radical SAM enzyme. |
21527678 |
| Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure. |
26438534 |
| AID Recognizes Structured DNA for Class Switch Recombination. |
28757211 |
| Alternative Conformations of the Archaeal Nop56/58-Fibrillarin Complex Imply Flexibility in Box C/D RNPs. |
17617422 |
| Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase. |
19847269 |
| An extended dsRBD is required for post-transcriptional modification in human tRNAs. |
26429968 |
| How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. |
17466622 |
| Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. |
20864039 |
| Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors. |
31138817 |
| Functional Implications for a Prototypical K-Turn Binding Protein from Structural and Dynamical Studies of 15.5K |
18044964 |
| Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. |
29542011 |
| Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. |
30149704 |
| Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. |
30976021 |
| Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1. |
19307714 |
| High precision NMR structure of YhhP, a novel Escherichia coli protein implicated in cell division. |
11080457 |
| Structure of the RNA-dependent RNA polymerase from COVID-19 virus. |
32277040 |
| Structural Insights into HIV-1 Vif-APOBEC3F Interaction. |
26537685 |
| Structural insights into the RNA methyltransferase domain of METTL16. |
29593291 |
| Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe |
16341225 |
| Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. |
22949673 |
| High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain. |
33483369 |
| The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. |
31328227 |
| Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. |
24402442 |
| The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. |
18208838 |
| Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. |
24402442 |
| The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL |
23804755 |
| Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G. |
18288108 |
| Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis |
17881823 |
| Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. |
29097656 |
| Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. |
19749755 |
| Structural insights into the molecular mechanism of the m(6)A writer complex. |
27627798 |
| Crystal structure of human diphosphoinositol phosphatase 1 |
19585659 |
| Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. |
20483913 |
| Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. |
16141067 |
| Structural and Dynamic Insights into Redundant Function of YTHDF Proteins. |
33073985 |
| Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. |
23617613 |
| The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. |
10366505 |
| tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. |
21059936 |
| Structure of the Yeast tRNA M7G Methylation Complex. |
18184583 |
| Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain. |
26416889 |
| First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. |
22181350 |
| 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure. |
27139641 |
| Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. |
19287006 |
| Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase |
21098051 |
| Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex |
27281194 |
| Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain |
15987897 |
| Structural Insights Into Methyltransferase Ksga Function in 30S Ribosomal Subunit Biogenesis |
22308031 |
| Human Abh3 Structure and Key Residues for Oxidative Demethylation to Reverse DNA/RNA Damage. |
16858410 |
| Crystal structure of the RluD pseudouridine Synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli |
14659742 |
| Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold |
14999002 |
| Crystal structure of archaeosine tRNA-guanine transglycosylase. |
12054814 |
| Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. |
10589681 |
| The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. |
10366505 |
| New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. |
33475202 |
| Dimerization of elongator protein 1 is essential for Elongator complex assembly. |
26261306 |
| Insights into Catalysis by a Knotted TrmD tRNA Methyltransferase. |
14583191 |
| Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. |
32303658 |
| Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity. |
27163633 |
| Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. |
32303658 |
| Sequence preference and structural heterogeneity of BZ junctions. |
30184200 |
| Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA |
22362734 |
| The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA. |
10535945 |
| Structural basis of biological nitrile reduction. |
22787148 |
| Architecture of the yeast Elongator complex. |
27974378 |
| Structural and Functional Insights Into tRNA Binding and Adenosine N1-Methylation by an Archaeal Trm10 Homologue. |
26673726 |
| The elp2 subunit is essential for elongator complex assembly and functional regulation |
25960406 |
| Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. |
16763562 |
| A cytidine deaminase edits C to U in transfer RNAs in Archaea |
19407206 |
| Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. |
29982645 |
| A Unique RNA Fold in the Ruma-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function |
15766524 |
| Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6 |
28531330 |
| Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. |
22167800 |
| Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. |
20972222 |
| Major Reorientation of tRNA Substrates Defines Specificity of Dihydrouridine Synthases. |
25902496 |
| Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA |
25542899 |
| Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. |
27373337 |
| Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces. |
20152150 |
| The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZ{alpha}ADAR1 |
19074195 |
| Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli. |
15050828 |
| Structure of H/ACA RNP Protein Nhp2p Reveals Cis/Trans Isomerization of a Conserved Proline at the RNA and Nop10 Binding Interface. |
21708174 |
| In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. |
23707380 |
| Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus |
20550164 |
| Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. |
31695039 |
| Structure of the Saccharomyces cerevisiae Cet1-Ceg1 mRNA Capping Apparatus. |
20159466 |
| Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. |
30149704 |
| Structure and function of the bacterial decapping enzyme NudC |
27428510 |
| The Crystal Structure of Pyrococcus Abyssi tRNA (Uracil-54, C5)-Methyltransferase Provides Insights Into its tRNA Specificity. |
18653523 |
| Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. |
10589681 |
| Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC |
17576679 |
| Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism. |
31101807 |
| Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome. |
33326748 |
| Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1. |
30149595 |
| Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase |
19416846 |
| Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. |
24717845 |
| Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria. |
9585521 |
| Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii |
18789948 |
| Structural and Functional Insights Into the Molecular Mechanism of Rrna M6A Methyltransferase Rlmj. |
23945937 |
| Crystallographic snapshots of eukaryotic dimethylallyltransferase acting on tRNA: insight into tRNA recognition and reaction mechanism. |
18852462 |
| Structure-function analysis of Escherichia coli MnmG (GidA), a highly conserved tRNA-modifying enzyme. |
19801413 |
| Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. |
30976021 |
| Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. |
31251801 |
| Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. |
19285505 |
| Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates. |
24951554 |
| Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. |
20864039 |
| Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure |
21844194 |
| The Crystal Structure of the Z[beta] Domain of the RNA-editing Enzyme ADAR1 Reveals Distinct Conserved Surfaces Among Z-domains. |
16023667 |
| Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion |
19373903 |
| Structure of the Kti11/Kti13 Heterodimer and its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2. |
25543256 |
| Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. |
32159918 |
| Structure of the guanylyltransferase domain of human mRNA capping enzyme. |
21636784 |
| Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function |
23676670 |
| The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs. |
16008351 |
| Sequence preference and structural heterogeneity of BZ junctions. |
30184200 |
| Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. |
18849968 |
| Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. |
18951093 |
| Crystal structure of the catalytic domain of RluD, the only rRNA pseudouridine synthase required for normal growth of Escherichia coli |
14730022 |
| High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. |
32994211 |
| Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli |
15078091 |
| The Crystal Structure of Pyrococcus Abyssi tRNA (Uracil-54, C5)-Methyltransferase Provides Insights Into its tRNA Specificity. |
18653523 |
| Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. |
20972222 |
| Structural insights into mechanisms of the small RNA methyltransferase HEN1. |
19812675 |
| Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. |
27491543 |
| Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme. |
34315827 |
| Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development. |
30197299 |
| Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. |
10654930 |
| Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit |
14566049 |
| Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. |
20404999 |
| Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. |
11139614 |
| Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure |
17188032 |
| Crystal Structure of Human Pus10, a Novel Pseudouridine Synthase. |
17900615 |
| Dual conformational recognition by Z-DNA binding protein is important for the B-Z transition process. |
33245772 |
| Structural basis of tRNA agmatinylation essential for AUA codon decoding |
22002223 |
| Structure of the Essential MTERF4:NSUN4 Protein Complex Reveals How an MTERF Protein Collaborates to Facilitate rRNA Modification. |
23022348 |
| The Crystal Structure and Small-Angle X-Ray Analysis of Csdl/Tcda Reveal a New tRNA Binding Motif in the Moeb/E1 Superfamily. |
25897750 |
| The Structure of the Rlmb 23S Rrna Methyltransferase Reveals a New Methyltransferase Fold with a Unique Knot |
12377117 |
| Analysis of GTP addition in the reverse (3'-5') direction by human tRNA His guanylyltransferase. |
33758037 |
| Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification. |
27258794 |
| Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics |
15342248 |
| Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. |
27991903 |
| Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP |
25084372 |
| Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. |
26470919 |
| Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion |
19373903 |
| Characterization and structure of the Aquifex aeolicus protein DUF752: a bacterial tRNA-methyltransferase (MnmC2) functioning without the usually fused oxidase domain (MnmC1) |
23091054 |
| Crystal Structure of the Avilamycin Resistance-Conferring Methyltransferase Avira from Streptomyces Viridochromogenes |
12742024 |
| The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE. |
17320904 |
| The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. |
15003446 |
| Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 |
19717466 |
| Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. |
31251801 |
| Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. |
22167800 |
| Structural and Functional Insights Into tRNA Binding and Adenosine N1-Methylation by an Archaeal Trm10 Homologue. |
26673726 |
| The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. |
16286935 |
| Box C/D guide RNAs recognize a maximum of 10 nt of substrates |
27625427 |
| Alternative Tertiary Structure of tRNA for Recognition by a Posttranscriptional Modification Enzyme |
12732145 |
| Differentiating analogous tRNA methyltransferases by fragments of the methyl donor. |
21602303 |
| Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile. |
8961936 |
| Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H. |
29491387 |
| Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate |
18565343 |
| Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon |
19435325 |
| The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain |
16793063 |
| Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. |
20194115 |
| Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold. |
15208439 |
| Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. |
20483913 |
| Structure of the thiostrepton-resistance methyltransferase-S-adenosyl-L-methionine complex and its interaction with ribosomal RNA |
19369248 |
| Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. |
33956156 |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
20558545 |
| A Complement to the Modern Crystallographer'S Toolbox: Caged Gadolinium Complexes with Versatile Binding Modes. |
24914962 |
| Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA. |
10364558 |
| Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G |
19153609 |
| Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. |
24489119 |
| Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. |
18951093 |
| Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. |
27519411 |
| Structural and Functional Insights Into the Molecular Mechanism of Rrna M6A Methyltransferase Rlmj. |
23945937 |
| Crystal Structure of Thermus thermophilus tRNA m(1)A(58) Methyltransferase and Biophysical Characterization of Its Interaction with tRNA. |
18262540 |
| Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation |
19749755 |
| Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate |
18565343 |
| Mechanistic insights into m6A modification of U6 snRNA by human METTL16. |
32266935 |
| Crystal structure of the human PRPK-TPRKB complex. |
33547416 |
| Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. |
24778178 |
| Structure of D-tyrosyl-tRNATyr deacylase using home-source Cu Kalpha and moderate-quality iodide-SAD data: structural polymorphism and HEPES-bound enzyme states |
20445234 |
| Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines. |
32970113 |
| Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy |
19806182 |
| Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit. |
21062819 |
| Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity |
15068804 |
| Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. |
27373337 |
| The APOBEC-2 crystal structure and functional implications for the deaminase AID. |
17187054 |
| Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii |
18789948 |
| Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases |
19303884 |
| Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance. |
31601908 |
| Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. |
33232691 |
| Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. |
20404999 |
| Snapshots of tRNA sulphuration via an adenylated intermediate |
16871210 |
| Crystal structure of the FTO protein reveals basis for its substrate specificity |
20376003 |
| Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon |
19446527 |
| ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. |
15087549 |
| Identification and Characterization of the Thermus thermophilus 5-Methylcytidine (m5C) Methyltransferase Modifying 23 S Ribosomal RNA (rRNA) Base C1942. |
22711535 |
| Structure of Protein L7Ae Bound to a K-Turn Derived from an Archaeal Box H/ACA sRNA at 1.8 A Resolution. |
15130481 |
| The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. |
10625422 |
| Structural basis of antagonism of human APOBEC3F by HIV-1 Vif. |
31792451 |
| Crystal Structure of Ruma, an Iron-Sulfur Cluster Containing E. Coli Ribosomal RNA 5-Methyluridine Methyltransferase. |
15016356 |
| Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit. |
21062819 |
| Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon |
19446527 |
| NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity. |
23695684 |
| Structural insights into the molecular mechanism of the m(6)A writer complex. |
27627798 |
| Defects in t 6 A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. |
31481669 |
| RNA-Protein Mutually Induced Fit: STRUCTURE OF ESCHERICHIA COLI ISOPENTENYL-tRNA TRANSFERASE IN COMPLEX WITH tRNA(Phe). |
19158097 |
| Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase |
19416846 |
| Structure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYC Promoter. |
22707729 |
| Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. |
25855808 |
| tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. |
21059936 |
| Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. |
9187657 |
| Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer. |
20399182 |
| First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. |
22181350 |
| Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain. |
26416889 |
| High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. |
32994211 |
| Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli |
21574198 |
| The Elongator Subcomplex Elp456 is a Hexameric Reca-Like ATPase. |
22343726 |
| Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA. |
29941968 |
| Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases. |
25902496 |
| Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition |
24616105 |
| Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. |
17412961 |
| A Left-Handed RNA Double Helix Bound by the Zalpha Domain of the RNA-Editing Enzyme ADAR1. |
17437712 |
| Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. |
19298824 |
| Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1. |
32051559 |
| Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. |
29596531 |
| The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL |
23804755 |
| Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition |
24616105 |
| Structure of the Kti11/Kti13 Heterodimer and its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2. |
25543256 |
| The Crystal Structure of the Methanocaldococcus jannaschii Multifunctional L7Ae RNA-Binding Protein Reveals an Induced-Fit Interaction with the Box C/D RNAs. |
16008351 |
| X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold |
15135053 |
| Crystal Structure of RNA 3'-Terminal Phosphate Cyclase, a Ubiquitous Enzyme with Unusual Topology |
10673421 |
| Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. |
22362751 |
| hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA. |
27679474 |
| Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. |
27491543 |
| Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. |
19386620 |
| Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. |
21366326 |
| Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. |
15894617 |
| Structural basis of 7SK RNA 5'-gamma-phosphate methylation and retention by MePCE. |
30559425 |
| A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1. |
24753571 |
| Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. |
19520088 |
| An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model |
19389408 |
| Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins. |
26318451 |
| DrosophilaYBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. |
32015133 |
| Crystal Structure of IscS, a Cysteine Desulfurase from Escherichia coli |
12860127 |
| Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. |
31116511 |
| Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA. |
29191651 |
| Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita |
22117216 |
| Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase. |
34381037 |
| How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. |
17466622 |
| Molecular Basis of Box C/D RNA-Protein Interactions; Cocrystal Structure of Archaeal L7Ae and a Box C/D RNA. |
15130473 |
| Snapshots of tRNA sulphuration via an adenylated intermediate |
16871210 |
| Steroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model |
24722331 |
| 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure. |
27139641 |
| Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA |
16373493 |
| Crystal structure of elongator subcomplex Elp4-6 |
22556426 |
| S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. |
23695253 |
| Crystal structure of human cytoplasmic tRNAHis-specific 5'-monomethylphosphate capping enzyme. |
31919512 |
| The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity. |
33094286 |
| Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. |
11746687 |
| From bacterial to human dihydrouridine synthase: automated structure determination. |
26143927 |
| Structural basis for site-specific ribose methylation by box C/D RNA protein complexes. |
21270896 |
| Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor. |
30197297 |
| Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. |
22065580 |
| METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes. |
34237194 |
| Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site. |
14999102 |
| Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. |
19520088 |
| Crystal structure of human diphosphoinositol phosphatase 1. |
19585659 |
| The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZ{alpha}ADAR1 |
19074195 |
| Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. |
28634302 |
| Structural basis for nucleotide recognition by the ectoenzyme CD203c. |
29717535 |
| Conformational Stability Adaptation of a Double-Stranded RNA-Binding Domain to Transfer RNA Ligand. |
31045345 |
| Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. |
21087996 |
| Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. |
16700551 |
| Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition |
21474448 |
| Structure and function of the bacterial decapping enzyme NudC. |
27428510 |
| Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA. |
22561317 |
| Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity |
15068804 |
| Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. |
22065580 |
| Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases. |
6237447 |
| Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain. |
23685212 |
| Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. |
21087996 |
| Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure |
21844194 |
| Box C/D guide RNAs recognize a maximum of 10 nt of substrates |
27625427 |
| Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development. |
30197299 |
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA |
19478803 |
| Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes |
18789337 |
| Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. |
20194115 |
| Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. |
20163168 |
| Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. |
34143953 |
| Pyruvate formate lyase is structurally homologous to type I ribonucleotide reductase. |
10425676 |
| The APOBEC3C crystal structure and the interface for HIV-1 Vif binding. |
23001005 |
| Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon |
19435325 |
| Structural Basis for the Specificity of Human Nudt16 and its Regulation by Inosine Monophosphate. |
26121039 |
| AID Recognizes Structured DNA for Class Switch Recombination. |
28757211 |
| Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs. |
31875550 |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
20558545 |
| Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv. |
11554794 |
| Control of Substrate Specificity by a Single Active Site Residue of the KsgA Methyltransferase. |
22142337 |
| Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. |
29234087 |
| Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario. |
29294097 |
| Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli |
15136037 |
| Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F. |
24185281 |
| Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft. |
15028724 |
| Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5. |
18384044 |
| Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module. |
15952786 |
| RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon |
19322199 |
| Structure of dihydrouridine synthase C (DusC) from Escherichia coli |
23908023 |
| Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. |
31116511 |
| Structural Basis for Sulfur Relay to RNA Mediated by Heterohexameric TusBCD Complex |
16472754 |
| CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid |
32796831 |
| Structural and catalytic roles of the human 18SrRNA methyltransferases DIMT1 in ribosome assembly and translation |
32616653 |
| Molecular basis of tRNA recognition by the Elongator complex. |
31309145 |
| Characterization of novel human Intragenic Antimicrobial Peptides, incorporation and release studies from ureasil-polyether hybrid matrix |
33321627 |
| Molecular architecture of the human U4/U6.U5 tri-snRNP. |
26912367 |
| Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation |
287811266 |
| Structures of the human pre-catalytic spliceosome and its precursor spliceosome. |
30315277 |
| Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. |
29245012 |
| RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function |
18554725 |
| Editing modifies the GABAA receptor subunit α3 |
17369310 |
| The expansion of Inosine at the wobble position of tRNAs, and its role in the evolution of proteomes |
30590541 |
| A limited number of pseudouridine residues in the human atac spliceosomal UsnRNAs as compared to human major spliceosomal UsnRNAs |
10580478 |
| Interaction mode between catalytic and regulatory subunits in glucosidase II involved in ER glycoprotein quality control |
27576940 |
| Archtecture of the yeast small subunit processome |
27980088 |
| The complete structure of small.subunit processome |
28945246 |
| Molecular architecture of the 90S small subunit pre-ribosome |
28244370 |
| Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states. |
32943522 |
| 90 S pre-ribosome transformation into the primordial 40 S subunit. |
32943521 |
| Conformational switches control early maturation of the eukaryotic small ribosomal subunit. |
31206356 |
| Visualizing late states of human 40S ribosomal subunit maturation. |
29875412 |
| A distinct assembly pathway of the human 39S late pre-mitoribosome |
34315873 |
| Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination |
35256818 |
| Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria |
21873425 |
| Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing |
8999813 |
| The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase |
8407891 |
| The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas |
25085003 |
| Crystal structure of an H/ACA box ribonucleoprotein particle |
16943774 |
| Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex |
18059286 |
| Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study. |
20615421 |
| Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase |
20575532 |
| Structural and functional evidence of high specificity of Cbf5 for ACA trinucleotide. |
21149572 |
| A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. |
10836796 |
| Functions and Regulation of RNA Editing by ADAR Deaminases |
20192758 |
| Chapter 21 - Aberrant AID Expression by Pathogen Infection |
doi.org/10.1016/B978-0-12-397933-9.00021-7 |
| Nucleolar maturation of the human small subunit processome. |
34516797 |
| 7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity. |
22985415 |
| KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. |
31061526 |
| Structural characterization of glycinamide-RNase-transformylase T fromMycobacterium tuberculosis. |
31894729 |
| Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. |
31636962 |
| THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates. |
34669960 |
| Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima |
33428944 |
| The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation |
35033535 |
| Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. |
29892076 |
| Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA) |
23877245 |
| Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase. |
22081394 |
| Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. |
32668200 |
| Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors. |
34813592 |
| Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. |
31586407 |
| Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. |
27582183 |
| Structural insights into the function of 23S rRNA methyltransferase RlmG (m2G1835) from Escherichia coli |
22753782 |
| Structural characterization of B. subtilis m1A22 tRNA methyltransferase TrmK: insights into tRNA recognition |
30931478 |
| Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold. |
14705938 |
| Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism. |
31227701 |
| rystal structure of the yeast heterodimeric ADAT2/3 deaminase. |
33272269 |
| Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI |
27711192 |
| Crystal Structure of Rlmm, the 2'O-Ribose Methyltransferase for C2498 of Escherichia Coli 23S Rrna |
22923526 |
| NMR-based Structural Analysis of Threonylcarbamoyl-AMP Synthase and Its Substrate Interactions. |
2MX1 |
| Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis |
27302132 |
| Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor |
24126054 |
| Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. |
23620299 |
| The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA. |
The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA. |
| Deciphering Determinants in Ribosomal Methyltransferases That Confer Antimicrobial Resistance |
30624914 |
| Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. |
35316014 |
| The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli |
25578970 |
| Structure of a reaction intermediate mimic in t6A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli. |
33524148 |
| Expanding the Kinome World: A New Protein Kinase Family Widely Conserved in Bacteria |
28890133 |
| Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide |
28300774 |
| The m1A58 modification in eubacterial tRNA: An overview of tRNA recognition and mechanism of catalysis by Trm |
26189113 |
| Structural insights into actin filament recognition by commonly used cellular actin markers |
32567727 |
| Structure of the Lifeact-F-actin complex |
33216759 |
| Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA |
34006170 |
| Crystal structure of the Tum1 protein from the yeast Saccharomyces cerevisiae. |
22587783 |
| The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins |
18491921 |
| Crystal structure of the dimeric Urm1 from the yeast Saccharomyces cerevisiae |
18260097 |
| Structural basis of dcp2 recognition and activation by dcp1 |
18280239 |
| The Structural Basis of Edc3- and Scd6-Mediated Activation of the Dcp1:Dcp2 Mrna Decapping Complex |
22085934 |
| Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. |
27183195 |
| Structural basis of mRNA-cap recognition by Dcp1-Dcp2. |
27694842 |
| Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme. |
28533364 |
| DcpS as a therapeutic target for spinal muscular atrophy. |
18839960 |
| Structures and mechanisms of tRNA methylation by METTL1-WDR4. |
36599982 |
| Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. |
36599985 |
| Epigenetic control of rDNA loci in response to intracellular energy status |
18485871 |
| Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. |
35333330 |
| Crystal structure of the RNA demethylase ALKBH5 from zebrafish. |
24561204 |
| Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. |
25452335 |
| Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues. |
24596302 |
| Structural basis of RNA processing by human mitochondrial RNase P |
34489609 |
| A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO. |
28553460 |
| Structural basis for inhibition of the fat mass and obesity associated protein (FTO) |
23547775 |
| Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors |
34762429 |
| Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein |
26457839 |
| Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates |
30718435 |
| Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1 |
30996080 |
| Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. |
33910046 |
| Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors |
35793358 |
| 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. |
34431664 |
| Crystal structures of the bifunctional tRNA methyltransferase Trm5a |
27629654 |
| Structural insight into the methyltransfer mechanism of the bifunctional Trm5 |
29214216 |
| The crystal structure of the Pyrococcus abyssi mono-functional methyltransferase PaTrm5b |
28911863 |
| Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome |
35650250 |
| Structural basis for late maturation steps of the human mitoribosomal large subunit. |
34135318 |
| Stepwise maturation of the peptidyl transferase region of human mitoribosomes. |
34135320 |
| Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. |
34135319 |
| Visualizing formation of the active site in the mitochondrial ribosome. |
34609277 |
| Structural and functional insights into human tRNA guanine transgylcosylase |
34241577 |
| Crystal structure of human METTL6, the m3C methyltransferase |
34862464 |
| Structural basis for METTL6-mediated m3C RNA methylation. |
34922197 |
| Cryo-EM structures of human m6A writer complexes. |
36167981 |
| AI-empowered integrative structural characterization of m 6 A methyltransferase complex. |
36357785 |
| Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. |
25412661 |
| Fragment Ligands of the m 6 A-RNA Reader YTHDF2. |
36110386 |
| Crystal structure of human YTHDC2 YTH domain. |
31472957 |
| Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1 |
29379020 |
| Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition. |
36528084 |
| The Solution Structure and DNA-Binding Properties of the Cold-Shock Domain of the Human Y-Box Protein Yb-1. |
11851341 |
| Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. |
31160337 |
| Structural basis of DNA binding to human YB-1 cold shock domain regulated by phosphorylation. |
32710623 |
| Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. |
27065196 |
| A Bump-Hole Approach for Directed RNA Editing. |
30581135 |
| Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. |
32597966 |
| Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. |
33939417 |
| The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. |
25914058 |
| Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. |
28452355 |
| Two different kinds of interaction modes of deaminase APOBEC3A with single-stranded DNA in solution detected by nuclear magnetic resonance. |
34792260 |
| Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia. |
18511415 |
| Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7. |
29946027 |
| Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. |
35320752 |
| Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7. |
25753663 |
| Structure of human telomerase holoenzyme with bound telomeric DNA. |
33883742 |
| Structure of active human telomerase with telomere shelterin protein TPP1. |
35418675 |
| Zipper head mechanism of telomere synthesis by human telomerase. |
34782750 |
| Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. |
35070167 |
| Mechanism of mitoribosomal small subunit biogenesis and preinitiation. |
35676484 |
| Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure. |
32075207 |
| Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10 |
16873247 |
| Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. |
22022266 |
| Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex. |
21637813 |
| Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2. |
33036230 |
| Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction |
10913247 |
| The crystal structure of the lysyl-tRNA synthetase (LysU) from Escherichia coli |
7735833 |
| Structural insights into dpCoA-RNA decapping by NudC. |
34074215 |
| Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs. |
35635723 |
| Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. |
35476445 |
| Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression? |
28045575 |
| Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. |
11567089 |
| Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs |
15963469 |
| The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis |
26743623 |
| Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control |
25404746 |
| Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. |
26829225 |
| Structure of a pre-catalytic spliceosome. |
28530653 |
| Architecture of the yeast small subunit processome. |
27980088 |
| The complete structure of the small-subunit processome. |
28945246 |
| Molecular architecture of the 90S small subunit pre-ribosome. |
28244370 |
| Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation |
29794219 |
| Biochemical and structural characterization of a thermostable Dps protein with His-type ferroxidase centers and outer metal-binding sites. |
32170832 |
| The Bacillus subtilis open reading frame ysgA encodes the SPOUT methyltransferase RlmP forming 2'- O-methylguanosine at position 2553 in the A-loop of 23S rRNA |
35710145 |
| The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction. |
22383337 |
| Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase |
16300397 |
| Conformational communication mediates the reset step in t6A biosynthesis. |
31114923 |
| The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t6A tRNA-modification. |
29741707 |
| The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase |
20047967 |
| Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans |
27084949 |
| The 18S ribosomal RNA m6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. |
32350990 |
| Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively |
23913415 |
| Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth |
31722427 |
| Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program |
31428936 |
| The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans |
33289480 |
| Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans |
33283887 |
| An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis |
37433804 |
| Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function |
37642556 |
| Biochemical characterization of mRNA capping enzyme from Faustovirus |
37625853 |
| Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease |
36865253 |
| TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival |
28784718 |
| Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner |
37204604 |
| Complete chemical structures of human mitochondrial tRNAs |
32859890 |
| NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice |
36949224 |
| Identification of a novel 5-aminomethyl-2-thiouridine methyltransferase in tRNA modification. |
36762482 |
| Crystal structure and cap binding analysis of the methyltransferase of langat virus |
36347437 |
| Structure and function of the NS5 methyltransferase domain from Usutu virus |
36334638 |
| A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome. |
36265859 |
| A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription |
34850409 |
| FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorphogenesis and flowering |
35101091 |
| Arabidopsis N6-methyladenosine methyltransferase FIONA1 regulates floral transition by affecting the splicing of FLC and the stability of floral activators SPL3 and SEP3 |
36416766 |
| FIONA1-Mediated m6 A Modification Regulates the Floral Transition in Arabidopsis |
34989479 |
| m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site |
36409063 |
| The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication |
15047892 |
| Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI |
28503769 |
| RNA methyltransferases in plants: Breakthroughs in function and evolution |
36502609 |
| Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI |
28503769 |