Modomics - A Database of RNA Modifications

Published on Jan. 12, 1998 in Tetrahedron Letters volume Volume 39, Issue 14,.

DOI: 10.1016/S0040-4039(98)00157-9


The synthesis of allyl- and allyloxycarbonyl (AOC)-protected RNA phosphoramidites is reported. The use of allyl and AOC groups allows the chemistry of solid-phase RNA synthesis to be expanded to include base-labile modified nucleosides, such as acetylcytidine. The allyl- and AOC-protective chemistry can be further expanded for the construction of RNAs on solid supports and affinity columns.