| A:Am |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
1 |
| A:Ar(p) |
phosphoribosylation |
acylation |
group addition |
H |
O[C@@H]1[C@H](OP(=O)(O)O)O[C@H](*)[C@H]1O |
phosphoribosyl |
phosphoribose |
2′O |
sugar |
1 |
| A:I |
deamination |
NH2/O exchange |
group exchange |
NH2 |
*=O |
oxo |
oxo |
C6 |
base/endocyclic |
1 |
| A:g6A |
carbamoylation |
acylation |
group addition |
H |
*C(=O)NCC(=O)O |
glycylcarbamoyl |
acyl |
N6 |
base/exocyclic |
1 |
| A:hn6A |
carbamoylation |
acylation |
group addition |
H |
*C(=O)NC(C(O)=O)C(O)CC |
hydroxynorvalylcarbamoyl |
acyl |
N6 |
base/exocyclic |
1 |
| A:i6A |
isopentenylation |
alkylation |
group addition |
H |
*CC=C(C)/C |
isopenthenyl |
hydrocarbon |
N6 |
base/exocyclic |
1 |
| A:m1A |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
N1 |
base/endocyclic |
1 |
| A:m2A |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
C2 |
base/endocyclic |
1 |
| A:m6A |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N6 |
base/exocyclic |
1 |
| A:m8A |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
C8 |
base/endocyclic |
1 |
| A:t6A |
carbamoylation |
acylation |
group addition |
H |
*C(=O)NC(C(O)=O)C(O)C |
threonylcarbamoyl |
acyl |
N6 |
base/exocyclic |
1 |
| Am:Im |
deamination |
NH2/O exchange |
group exchange |
NH2 |
*=O |
oxo |
oxo |
C6 |
base/endocyclic |
2 |
| Am:m1Am |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
N1 |
base/endocyclic |
2 |
| Am:m6Am |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N6 |
base/exocyclic |
2 |
| C:C+ |
agmatinylation |
amination |
group addition |
O |
*NCCCCCCNC(=N)N |
agmatinyl |
polyamine |
C2 |
base/endocyclic |
1 |
| C:Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
1 |
| C:U |
deamination |
NH2/O exchange |
group exchange |
NH2 |
*=O |
oxo |
oxo |
C4 |
base/endocyclic |
0 |
| C:ac4C |
acetylation |
acylation |
group addition |
H |
*C(=O)C |
acetyl |
acyl |
N4 |
base/exocyclic |
1 |
| C:f5C |
formylation |
acylation |
group addition |
H |
*C([H])=O |
formyl |
acyl |
C5 |
base/endocyclic |
3 |
| C:hm5C |
hydroxymethylation |
hydroxymethylation |
group addition |
H |
*CO |
hydroxymethyl |
hydroxyalkyl |
C5 |
base/endocyclic |
3 |
| C:ho5C |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C5 |
base/endocyclic |
1 |
| C:k2C |
lysylation |
amination |
group addition |
O |
*NCCCCC(N)C(O)=O |
lysyl |
amino acid |
C2 |
base/endocyclic |
1 |
| C:m3C |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
N3 |
base/endocyclic |
1 |
| C:m4C |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N4 |
base/exocyclic |
1 |
| C:m5C |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5 |
base/endocyclic |
1 |
| C:s2C |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
1 |
| Cm:ac4Cm |
acetylation |
acylation |
group addition |
H |
*C(=O)C |
acetyl |
acyl |
N4 |
base/exocyclic |
2 |
| Cm:f5Cm |
formylation |
acylation |
group addition |
H |
*C([H])=O |
formyl |
acyl |
C5 |
base/endocyclic |
4 |
| Cm:m4Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N4 |
base/exocyclic |
2 |
| Cm:m5Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5 |
base/endocyclic |
2 |
| CoApN:acCoApN |
acetylation |
acylation |
group addition |
H |
*C(=O)C |
acetyl |
acyl |
O5'.P3 |
extra group |
2 |
| CoApN:malonyl-CoApN |
carboxylation |
acylation |
group addition |
H |
*C(=O)CC(=O)O |
malonyl |
acyl |
O5'.P3 |
extra group |
2 |
| CoApN:succinyl-CoApN |
carboxylation |
acylation |
group addition |
H |
*C(=O)CCC(=O)O |
succinyl |
acyl |
O5'.P3 |
extra group |
2 |
| D:acp3D |
3-amino-3-carboxypropylation |
acylation |
group addition |
H |
*CCC(N)C(=O)O |
3-amino-3-carboxypropyl |
amino acid |
N3 |
base/endocyclic |
2 |
| D:m5D |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5 |
base/endocyclic |
2 |
| G:Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
1 |
| G:Gr(p) |
phosphoribosylation |
acylation |
group addition |
H |
O[C@@H]1[C@H](OP(=O)(O)O)O[C@H](*)[C@H]1O |
phosphoribosyl |
phosphoribose |
2′O |
sugar |
1 |
| G:m1G |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1 |
base/endocyclic |
1 |
| G:m2G |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
1 |
| G:m7G |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
N7 |
base/endocyclic |
1 |
| Gm:m1Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1 |
base/endocyclic |
2 |
| Gm:m2Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
2 |
| GpppN:m7GpppN |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
N7 |
base/endocyclic |
3 |
| I:Im |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| I:m1I |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1 |
base/endocyclic |
2 |
| Im:m1Im |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1 |
base/endocyclic |
3 |
| N:Nm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2ʹO |
sugar |
None |
| OHyW:o2yW |
O-peroxidaton |
oxygen addition |
group addition |
H |
*O* |
peroxide |
peroxide |
N1.O4 |
extra group |
7 |
| OHyWx:OHyWy |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1.O6 |
extra group |
6 |
| OHyWy:OHyW |
methoxycarbonylation |
acylation |
group addition |
H |
*C(=O)OC, *C |
methoxycarbonyl |
methoxycarbonyl |
N1.N5 |
extra group |
7 |
| Q:Qbase |
N-glycosyl bond hydrolysis |
hydrolysis |
group removal |
C1=CC(C(C1NCC2=CN(C3=C2C(=O)N=C(N3)N)C4C(C(C(O4)CO)O)O)O)O |
*O |
hydroxyl |
hydroxyl |
C1ʹ |
sugar |
0 |
| Q:galQ |
galactosylation |
glycosylation |
group addition |
H |
O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@]1(O)* |
galactosyl |
saccharide |
C7.O5 |
extra group |
3 |
| Q:gluQ |
glutamylation |
acylation |
group addition |
H |
*OC(=O)C(N)CCC(=O)O |
glutamyl |
amino acid |
C7.O5 |
base/exocyclic |
3 |
| Q:manQ |
mannosylation |
glycosylation |
group addition |
H |
OC1[C@H](O)[C@H](O)C(CO)O[C@]1(*)[H] |
mannosyl |
saccharide |
C7.O5 |
extra group |
3 |
| Qbase:Q |
transglycosylation |
base exchange |
group exchange |
NC2=Nc1ncnc1C(=O)N2 |
C1=CC(C(C1NCC2=CN(C3=C2C(=O)N=C(N3)N)C4C(C(C(O4)CO)O)O)O)O |
Qbase |
nucleobase |
C1ʹ |
sugar |
0 |
| U:D |
hydrogenation |
hydrogenation |
group addition |
none |
*H, *H |
hydrogen |
hydrogen |
C5,C6 |
base/endocyclic |
1 |
| U:Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
1 |
| U:Y |
pseudouridine formation |
isomerization |
isomerization |
none |
none |
none |
none |
N1, C5 |
base/endocyclic |
1 |
| U:acp3U |
3-amino-3-carboxypropylation |
acylation |
group addition |
H |
*CCC(N)C(=O)O |
3-amino-3-carboxypropyl |
amino acid |
N3 |
base/endocyclic |
1 |
| U:cm5U |
carboxymethylation |
alkylation |
group addition |
H |
*CC(=O)O |
carboxymethyl |
carboxymethyl |
C5 |
base/endocyclic |
1 |
| U:cmnm5U |
carboxymethylaminomethylation |
aminoalkylation |
group addition |
H |
*CNCC(=O)O |
carboxymethylaminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
1 |
| U:ho5U |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C5 |
base/endocyclic |
1 |
| U:m3U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N3 |
base/endocyclic |
1 |
| U:m5U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5 |
base/endocyclic |
1 |
| U:mcm5s2U |
thiolation |
|
group addition |
|
|
|
|
None |
|
1 |
| U:ncm5U |
carbamoylmethylation |
alkylation |
group addition |
H |
*CC(=O)N |
carbamoylmethyl |
acyl |
C5 |
base/endocyclic |
1 |
| U:nm5U |
aminomethylation |
aminoalkylation |
group addition |
H |
*CN |
aminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
2 |
| U:s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
1 |
| U:s4U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C4 |
base/endocyclic |
1 |
| U:tm5U |
taurinomethylation |
aminoalkylation |
group addition |
H |
*CNCCS(=O)(O)=O |
taurinomethyl |
aminoalkyl |
C5 |
base/endocyclic |
1 |
| Um:cmnm5Um |
carboxymethylaminomethylation |
aminoalkylation |
group addition |
H |
*CNCC(=O)O |
carboxymethylaminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
2 |
| Um:s2Um |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
2 |
| Y:Ym |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| Y:acp3Y |
3-amino-3-carboxypropylation |
acylation |
group addition |
H |
*CCC(N)C(=O)O |
3-amino-3-carboxypropyl |
amino acid |
N3 |
base/endocyclic |
2 |
| Y:m1Y |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1 |
base/endocyclic |
2 |
| Y:m3Y |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N3 |
base/endocyclic |
2 |
| ac4C:ac4Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2'O |
sugar |
2 |
| acp3U:acp3Y |
pseudouridine formation |
isomerization |
isomerization |
none |
none |
none |
none |
N1, C5 |
base/endocyclic |
2 |
| chm5U:mchm5U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.O3 |
extra group |
3 |
| cm5U:chm5U |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C5.C1 |
extra group |
2 |
| cm5U:mcm5U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.O3 |
extra group |
2 |
| cmnm5U:cmnm5Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| cmnm5U:cmnm5s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
2 |
| cmnm5U:nm5U |
decarboxymethylation |
dealkylation |
group removal |
*C(=O)O |
*[H] |
hydrogen |
hydrogen |
C5.N2 |
extra group |
2 |
| cmnm5ges2U:nm5ges2U |
decarboxymethylation |
dealkylation |
group removal |
*C(=O)O |
*[H] |
hydrogen |
hydrogen |
C5.N2 |
extra group |
4 |
| cmnm5s2U:cmnm5ges2U |
geranylation |
alkylation |
group addition |
none |
C\C(C)=C\CCC(\C)=C\C* |
geranyl |
hydrocarbon |
C2.S1 |
extra group |
3 |
| cmnm5s2U:cmnm5se2U |
S/Se exchange |
S/Se exchange |
group exchange |
S |
*[Se] |
seleno |
seleno |
C2 |
base/endocyclic |
3 |
| cmnm5s2U:nm5s2U |
decarboxymethylation |
dealkylation |
group removal |
*C(=O)O |
*[H] |
hydrogen |
hydrogen |
C5.N2 |
extra group |
3 |
| cmnm5se2U:nm5se2U |
decarboxymethylation |
dealkylation |
group removal |
*C(=O)O |
*[H] |
hydrogen |
hydrogen |
C5.N2 |
extra group |
4 |
| cmo5U:mcmo5U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.O4 |
extra group |
4 |
| ct6A:t6A |
hydration |
hydration |
group addition |
none |
O |
water molecule |
other |
N6.O2, N6.C4 |
extra group |
1 |
| f5C:f5Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| ges2U:cmnm5ges2U |
carboxymethylaminomethylation |
aminoalkylation |
group addition |
H |
*CNCC(=O)O |
carboxymethylaminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
3 |
| ges2U:nm5ges2U |
aminomethylation |
aminoalkylation |
group addition |
H |
*CN |
aminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
4 |
| hm5C:f5C |
formylation |
oxidation |
group addition |
|
|
|
|
None |
|
3 |
| hm5C:f5Cm |
formylation |
acylation |
group addition |
|
*C([H])=O |
formyl |
acyl |
C5 |
base/endocyclic |
4 |
| hm6A:f6A |
dehydrogenation |
dehydrogenation |
group removal |
H, H |
none |
none |
none |
N6.C1, N6.O2 |
extra group |
3 |
| hn6A:ms2hn6A |
methylthiolation |
thioalkylation |
group addition |
H |
*SC |
methylthio |
thioalkyl |
C2 |
base/endocyclic |
2 |
| ho5U:cmo5U |
carboxymethylation |
alkylation |
group addition |
H |
*CC(=O)O |
carboxymethyl |
carboxymethyl |
C5.O1 |
extra group |
3 |
| ho5U:mo5U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.O1 |
extra group |
2 |
| ho5U:mo5U |
methylation |
|
group exchange |
|
None |
methyl group |
methyl group |
|
None |
None |
| i6A:io6A |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C4.C5 |
extra group |
2 |
| i6A:ms2i6A |
methylthiolation |
thioalkylation |
group addition |
H |
*SC |
methylthio |
thioalkyl |
C2 |
base/endocyclic |
2 |
| imG-14:imG |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N3 |
base/endocyclic |
3 |
| imG-14:imG2 |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1.C1 |
extra group |
3 |
| imG-14:yW-86 |
3-amino-3-carboxypropylation |
acylation |
group addition |
H |
*CCC(N)C(=O)O |
3-amino-3-carboxypropyl |
amino acid |
N1.C1 |
extra group |
3 |
| imG2:mimG |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N3 |
base/endocyclic |
4 |
| inm5U:inm5Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2'O |
sugar |
4 |
| io6A:ms2io6A |
methylthiolation |
thioalkylation |
group addition |
H |
*SC |
methylthio |
thioalkyl |
C2 |
base/endocyclic |
3 |
| m1A:A |
demethylation |
deoxygenation |
group removal |
|
|
|
|
None |
|
0 |
| m1A:m1Am |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| m1A:m1I |
deamination |
NH2/O exchange |
group exchange |
NH2 |
*=O |
oxo |
oxo |
C6 |
base/endocyclic |
2 |
| m1G:imG-14 |
acetylation |
condensation-cyclization |
group addition |
H,H2 |
*=C(C)* |
anhydro-acetic acid |
hydrocarbon |
N1.C1, N2 |
|
2 |
| m1G:m1Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2'O |
sugar |
2 |
| m1I:m1Im |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
3 |
| m1Y:m1acp3Y |
3-amino-3-carboxypropylation |
acylation |
group addition |
H |
*CCC(N)C(=O)O |
3-amino-3-carboxypropyl |
amino acid |
N3 |
base/endocyclic |
3 |
| m2,2G:m2,2Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
3 |
| m2,7G:m2,2,7G |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
3 |
| m2,7G:m2,7Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
3 |
| m2,7GpppN:m2,2,7GpppN |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
5 |
| m2A:m2,8A |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
C8 |
base/endocyclic |
2 |
| m2G:m2,2G |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
2 |
| m2G:m2Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| m2Gm:m2,2Gm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
3 |
| m2Gm:m2,7Gm |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
N7 |
base/endocyclic |
3 |
| m3C:C |
demethylation |
deoxygenation |
group removal |
|
|
|
|
C3 |
|
None |
| m3U:m3Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| m4,4C:m4,4Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
3 |
| m4C:m4,4C |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N4 |
base/exocyclic |
2 |
| m4C:m4Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| m4Cm:m4,4Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N4 |
base/exocyclic |
3 |
| m5C:hm5C |
hydroxylation |
hydroxylation |
group addition |
|
*CO |
hydroxymethyl |
hydroxyalkyl |
None |
base/endocyclic |
2 |
| m5C:m5Cm |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2'O |
sugar |
2 |
| m5U:m5Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| m5U:m5s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
2 |
| m6,6A:m6,6Am |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
3 |
| m6A:A |
demethylation |
dealkylation |
group removal |
*C |
*H |
hydrogen |
hydrogen |
N6 |
base/exocyclic |
0 |
| m6A:hm6A |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
N6.C1 |
extra group |
2 |
| m6A:m6,6A |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N6 |
base/exocyclic |
2 |
| m6A:m6Am |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| m6A:ms2m6A |
methylthiolation |
thioalkylation |
group addition |
H |
*SC |
methylthio |
thioalkyl |
C2 |
base/endocyclic |
2 |
| m6Am:m6,6Am |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N6 |
base/exocyclic |
3 |
| m7G:m2,7G |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
2 |
| m7GpppN:m2,7GpppN |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N2 |
base/exocyclic |
4 |
| m8A:m2,8A |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
C2 |
base/endocyclic |
2 |
| mchm5U:mchm5Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2'O |
sugar |
4 |
| mcm5U:mchm5U |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C5.C1 |
extra group |
3 |
| mcm5U:mcm5Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2'O |
sugar |
3 |
| mcm5U:mcm5s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
3 |
| mcm5Um:mchm5Um |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C5.C1 |
extra group |
4 |
| mcmo5U:mcmo5Um |
methylation |
alkylation |
group addition |
|
*C |
methyl |
hydrocarbon |
O5'.O3A |
phosphate |
3 |
| mnm5U:mnm5s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
4 |
| mnm5s2U:mnm5ges2U |
geranylation |
alkylation |
group addition |
none |
C\C(C)=C\CCC(\C)=C\C* |
geranyl |
hydrocarbon |
C2.S1 |
extra group |
5 |
| mnm5s2U:mnm5se2U |
S/Se exchange |
S/Se exchange |
group exchange |
S |
*[Se] |
seleno |
seleno |
C2 |
base/endocyclic |
5 |
| mpN:mmpN |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
O5'.O3A |
phosphate |
3 |
| ms2i6A:ms2io6A |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C4.C5 |
extra group |
3 |
| ncm5U:nchm5U |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
C5.C1 |
extra group |
2 |
| ncm5U:ncm5Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2′O |
sugar |
2 |
| ncm5U:ncm5s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
2 |
| nm5U:inm5U |
isopentenylation |
alkylation |
group addition |
H |
*CC=C(C)/C |
isopenthenyl |
hydrocarbon |
C5.N2 |
base/exocyclic |
3 |
| nm5U:mnm5U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.N2 |
extra group |
3 |
| nm5U:nm5s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
3 |
| nm5ges2U:mnm5ges2U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.N2 |
extra group |
5 |
| nm5s2U:inm5s2U |
isopentenylation |
alkylation |
group addition |
H |
*CC=C(C)/C |
isopenthenyl |
hydrocarbon |
C5.N2 |
base/exocyclic |
4 |
| nm5s2U:mnm5s2U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.N2 |
extra group |
4 |
| nm5s2U:nm5ges2U |
geranylation |
alkylation |
group addition |
none |
C\C(C)=C\CCC(\C)=C\C* |
geranyl |
hydrocarbon |
C2.S1 |
extra group |
4 |
| nm5s2U:nm5se2U |
S/Se exchange |
S/Se exchange |
group exchange |
S |
*[Se] |
seleno |
seleno |
C2 |
base/endocyclic |
4 |
| nm5se2U:mnm5se2U |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
C5.N2 |
extra group |
5 |
| oQ:Q |
epoxide deoxygenation |
deoxygenation |
group removal |
O |
none |
none |
none |
C7.C4,C7.C6 |
extra group |
2 |
| pN:mpN |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
O5'.O2A |
phosphate |
2 |
| pN:pG(pN) |
5ʹ-3ʹ guanylylation |
nucleotide addition |
group addition |
OH |
[O-]P(=O)(O)OC[C@@H]3O[C@H](n2cnc1c2N=C(N)NC1=O)[C@@H](O)[C@H]3O* |
guanylyl |
nucleotide |
O5'.P3 |
phosphate |
0 |
| ppN:GpppN |
5ʹ-5ʹ guanylylation |
nucleotide addition |
group addition |
*P(=O)(O)OP(=O)(O)O |
[O-]P(=O)(O)OC[C@@H]3O[C@H](n2cnc1c2N=C(N)NC1=O)[C@@H](O)[C@H]3O* |
guanylyl |
nucleotide |
O5'.P3 |
phosphate |
0 |
| pppN:ApppN |
group addition |
group addition |
group exchange |
|
O |
water molecule |
other |
None |
extra group |
0 |
| pppN:AppppN |
group addition |
group addition |
group addition |
|
O |
water molecule |
other |
None |
extra group |
1 |
| pppN:ApppppN |
group addition |
group addition |
group addition |
|
*CC(=O)N |
carbamoylmethyl |
acyl |
None |
base/endocyclic |
0 |
| pppN:CoApN |
group addition |
group addition |
group addition |
*P(=O)(O)OP(=O)(O)O |
SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@@H](n2cnc1c(N)ncnc12)C(O)[C@H]3O* |
dephospho-coenzyme A |
other group |
O5'.P3 |
phosphate |
1 |
| pppN:NADpN |
nicotinamide adenine dinucleotidylation |
nucleotide addition |
group addition |
*P(=O)(O)OP(=O)(O)O |
NC(=O)c1ccc[n+](c1)C5OC(COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@@H](n3cnc2c(N)ncnc23)C(O)[C@H]4O*)C(O)C5O |
nicotinamide adenine dinucleotide |
nucleotide |
O5'.P3 |
phosphate |
1 |
| pppN:m6ApppN |
group addition |
group addition |
group addition |
|
O |
water molecule |
other |
None |
extra group |
0 |
| pppN:m6AppppN |
group addition |
group addition |
group addition |
|
O |
water molecule |
other |
None |
extra group |
1 |
| pppN:m6ApppppN |
group addition |
group addition |
group addition |
|
O |
water molecule |
other |
None |
extra group |
1 |
| pppN:m7GppppN |
group addition |
group addition |
group addition |
|
O |
water molecule |
other |
None |
extra group |
1 |
| pppN:mpppN |
methylation |
alkylation |
group addition |
none |
*C |
methyl |
hydrocarbon |
O5'.O2G |
phosphate |
1 |
| pppN:pN |
excision from a larger primary transcript |
hydrolysis |
group removal |
*P(=O)(O)OP(=O)(O)O |
*[H] |
hydrogen |
hydrogen |
O5'.O3A |
phosphate |
0 |
| pppN:ppN |
dephosphorylation |
hydrolysis |
group removal |
*P(O)(O)=O |
*[H] |
hydrogen |
hydrogen |
O5'.O3B |
phosphate |
1 |
| preQ0:G+ |
amination |
amination |
group addition |
none |
*N, *[H] |
ammonia |
ammonia |
C7.C1, C7.N2 |
extra group |
1 |
| preQ0base:preQ0 |
transglycosylation |
base exchange |
group exchange |
NC2=Nc1ncnc1C(=O)N2 |
NC2=Nc1n(*)cc(C#N)c1C(=O)N2 |
preQ0 base |
nucleobase |
C1ʹ |
sugar |
0 |
| preQ0base:preQ1base |
hydrogenation |
hydrogenation |
group addition |
none |
*H |
hydrogen |
hydrogen |
C7.N2 |
extra group |
-1 |
| preQ1:oQ |
2,3-epoxy-4,5-dihydroxycyclopentanylation |
alkylation |
group addition |
H |
*C2C1OC1C(O)C2O |
2,3-epoxy-4,5-dihydroxycyclopentane group |
epoxycyclopentane group |
C7.N2 |
extra group |
1 |
| preQ1base:preQ1 |
transglycosylation |
base exchange |
group exchange |
NC2=Nc1ncnc1C(=O)N2 |
NC2=Nc1ncc(CN)c1C(=O)N2 |
preQ1 base |
nucleobase |
C1ʹ |
sugar |
0 |
| s2U:cmnm5s2U |
carboxymethylaminomethylation |
aminoalkylation |
group addition |
H |
*CNCC(=O)O |
carboxymethylaminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
2 |
| s2U:ges2U |
geranylation |
alkylation |
group addition |
none |
C\C(C)=C\CCC(\C)=C\C* |
geranyl |
hydrocarbon |
C2.S1 |
extra group |
2 |
| s2U:nm5s2U |
aminomethylation |
aminoalkylation |
group addition |
H |
*CN |
aminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
3 |
| s2U:s2Um |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
2'O |
sugar |
2 |
| s2U:se2U |
S/Se exchange |
S/Se exchange |
group exchange |
S |
*[Se] |
seleno |
seleno |
C2 |
base/endocyclic |
2 |
| s2U:tm5s2U |
taurinomethylation |
aminoalkylation |
group addition |
H |
*CNCCS(=O)(O)=O |
taurinomethyl |
aminoalkyl |
C5 |
base/endocyclic |
2 |
| se2U:cmnm5se2U |
carboxymethylaminomethylation |
aminoalkylation |
group addition |
H |
*CNCC(=O)O |
carboxymethylaminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
3 |
| se2U:nm5se2U |
aminomethylation |
aminoalkylation |
group addition |
H |
*CN |
aminomethyl |
aminoalkyl |
C5 |
base/endocyclic |
4 |
| t6A:ct6A |
dehydration |
dehydration |
group removal |
H, *O |
none |
none |
none |
N6.O2, N6.C4 |
extra group |
2 |
| t6A:m6t6A |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N6 |
base/exocyclic |
2 |
| t6A:ms2t6A |
methylthiolation |
thioalkylation |
group addition |
H |
*SC |
methylthio |
thioalkyl |
C2 |
base/endocyclic |
2 |
| tm5U:tm5s2U |
O/S exchange |
O/S exchange |
group exchange |
O |
*=S |
thio |
sulphur |
C2 |
base/endocyclic |
2 |
| yW-58:yW |
methoxycarbonylation |
acylation |
group addition |
H |
*C(=O)OC |
methoxycarbonyl |
methoxycarbonyl |
N1.N5 |
extra group |
6 |
| yW-72:OHyWx |
hydroxylation |
oxygen addition |
group addition |
H |
*O |
hydroxyl |
hydroxyl |
N1.C3 |
extra group |
5 |
| yW-72:yW-58 |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N1.C6 |
extra group |
5 |
| yW-86:yW-72 |
methylation |
alkylation |
group addition |
H |
*C |
methyl |
hydrocarbon |
N3 |
base/endocyclic |
4 |