Modomics - A Database of RNA Modifications

Published on None in volume (2000) Structure 8: 13 .

PubMed ID: 10673421 

DOI: 10.1016/s0969-2126(00)00076-9


RNA cyclases are a family of RNA-modifying enzymes that are conserved in eucarya, bacteria and archaea. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. These enzymes might be responsible for production of the cyclic phosphate RNA ends that are known to be required by many RNA ligases in both prokaryotes and eukaryotes.