Published on Dec. 4, 1995 in Tetrahedron Letters volume Volume 36, Issue 49,.

DOI: 10.1016/0040-4039(95)01953-F


Abstract:

Use of methylamine or methylamine/ammonium hydroxide as a cleavage and deprotection reagent for the solid phase synthesis of Oligoribonucleotides has significantly increased the yield of the full length Oligoribonucleotides as compared to the use of conventional ammonium hydroxide/ethanol


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