| Name | Bladder cancer (A:m6A) |
| Description | METTL3 is upregulated in bladder cancer cells and tissues. METTL3 could enhance the recognition of pri-miR221/222, which plays an oncogenic role in bladder cancer, by DGCR8 and the subsequent processing to mature miRNAs in an m6A manner. |
| Related RNA reaction | A:m6A |
| Found in RNA | miRNA |
| Modified Transcript | pri-miR221/ 222 |
| Mapping Technology | |
| Quantification techniques | m6A dot blot assay, MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 973 | METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner. | Jing-Zi Wang,Xiao Yang,Hao Yu,Rui Zhou,Hong-Cheng Lu,Wen-Bo Yuan,Jian-Chen Lu,Zi-Jian Zhou,Qiang Lu,Ji-Fu Wei, | Mol Cancer | [details] | 31228940 | 10.1186/s12943-019-1036-9 |