Summary:

NameBladder cancer (A:m6A)
DescriptionMETTL3 is upregulated in bladder cancer cells and tissues. METTL3 could enhance the recognition of pri-miR221/222, which plays an oncogenic role in bladder cancer, by DGCR8 and the subsequent processing to mature miRNAs in an m6A manner.
Related RNA reactionA:m6A
Found in RNAmiRNA
Modified Transcriptpri-miR221/ 222
Mapping Technology
Quantification techniquesm6A dot blot assay, MeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
973 METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner. Jie Han Mol Cancer [details] 31228940 10.1186/s12943-019-1036-9

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