Modomics - A Database of RNA Modifications


NameBrain atrophy (A:m6A)
DescriptionStructural brain atrophy in carriers of the FTO risk allele (SNP rs9939609) is identified in healthy elderly subjects . Those carrying at least one copy of the risk allele showed brain tissue deficits in the frontal and the occipital lobes, areas that are also associated with volume reductions in subjects with higher BMI.
Related RNA reactionA:m6A
Modified Transcript
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
978 A commonly carried allele of the obesity-related FTO gene is associated with reducedbrain volume in the healthy elderly. Ho AJ Proc Natl Acad Sci USA [details] 20404173 0910878107

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