Summary:

NameBreast cancer (A:m6A)
Descriptionm6A upregulates the levels of HBXIP; increases malignant cell growth and proliferation. METTL3 promoted the expression of HBXIP through m6A modification; high expression of METTL3 is related to increased levels of HBXIP in clinical breast cancer tissues and breast cancer cells; METTL3 increases the levels of expression of HBXIP by affecting m6A modification levels on HBXIP mRNA.METTL3 has increased expression in breast cancer cells and has an essential role in progression.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptHBXIP
Mapping TechnologyNone
Quantification techniquesMeRIP qRT-PCR; m6A dot blot assay

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
982 HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancervia inhibiting tumor suppressor let-7g. Cai X Cancer Lett [details] 29174803 S0304-3835(17)30740-1

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