Summary:

NameCervical cancer (A:m6A)
Descriptionm6A methylation of β-catenin was found to be related to chemo/radiotherapy resistance of CSCC cells. Increased levels of FTO in those cells induce a decreased methylation level in β-catenin and an increased chemo/radiotherapy resistance through the ERCC1 axis.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified Transcriptβ-catenin
Mapping TechnologyNone
Quantification techniquesMeRIP-RT-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
993 FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation. Shun Zhou Mol Carcinog [details] 29315835 10.1002/mc.22782

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