| Name | Cervical cancer (A:m6A) |
| Description | m6A methylation of β-catenin was found to be related to chemo/radiotherapy resistance of CSCC cells. Increased levels of FTO in those cells induce a decreased methylation level in β-catenin and an increased chemo/radiotherapy resistance through the ERCC1 axis. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | β-catenin |
| Mapping Technology | None |
| Quantification techniques | MeRIP-RT-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| FTO | Alpha-ketoglutarate-dependent dioxygenase FTO | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 993 | FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation. | Shun Zhou | Mol Carcinog | [details] | 29315835 | 10.1002/mc.22782 |