| Name | Colorectal cancer (A:m6A) |
| Description | It was found that the negative expression of METTL3 is associated with larger tumor size and higher metastasis rates in CRC. Decreased level of METTL3 increases P38/ERK pathway expression. The increased expression of p-P38 and p-ERK is associated with CRC cells proliferation, migration and invasion. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | P38/ERK pathway |
| Mapping Technology | |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 998 | mA methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways. | Yikan Cheng,Shubiao Ye,Jianwei Zhang,Runqing Huang,Peisi Li,Huashan Liu,Qiling Deng,Xianrui Wu,Ping Lan, | Onco Targets Ther | [details] | 31239708 | 10.2147/OTT.S201052 |