Modomics - A Database of RNA Modifications


NameColorectal cancer (A:m6A)
DescriptionIt was found that the negative expression of METTL3 is associated with larger tumor size and higher metastasis rates in CRC. Decreased level of METTL3 increases P38/ERK pathway expression. The increased expression of p-P38 and p-ERK is associated with CRC cells proliferation, migration and invasion.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptP38/ERK pathway
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit tumor-suppressor Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
998 mA methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways. Ru Deng Onco Targets Ther [details] 31239708 10.2147/OTT.S201052

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