Summary:

NameHepatocellular carcinoma (A:m6A)
Descriptionm6A methylation level decreases the expression of tumor suppressor genes like SOCS2. The upregulation of METTL3 in HCC mediates this event through an m6A-YTHDF2-dependent mechanism and increases cancer cells proliferation, migration and metastasis formation
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptSOCS2
Mapping TechnologyMeRIP-seq
Quantification techniquesMeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1037 RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Mengnuo Chen Hepatology [details] 29171881 10.1002/hep.29683
1038 Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets. Yu Zhou Cancer Manag Res [details] 31118805 10.2147/CMAR.S191565

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