| Name | Hepatocellular carcinoma (A:m6A) |
| Description | m6A methylation level decreases the expression of tumor suppressor genes like SOCS2. The upregulation of METTL3 in HCC mediates this event through an m6A-YTHDF2-dependent mechanism and increases cancer cells proliferation, migration and metastasis formation |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | SOCS2 |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1037 | RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. | Mengnuo Chen | Hepatology | [details] | 29171881 | 10.1002/hep.29683 |
| 1038 | Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets. | Yu Zhou | Cancer Manag Res | [details] | 31118805 | 10.2147/CMAR.S191565 |