Summary:

NameHypoxia mediated Pulmonary hypertension (A:m6A)
Descriptionm6A level in circRNAs is decreased in lungs of HPH and in particular, two downregulated m6A circRNAs were identified in HPH: circXpo6 and circTmtc3. Furthermore, m6A level influence the stability of circRNAs, thus affecting circRNA–miRNA–mRNA co-expression network in HPH, resulting in the activation of Wnt and FoxO signaling pathways.
Related RNA reactionA:m6A
Found in RNAcircRNA
Modified TranscriptcircXpo6, circTmtc3
Mapping Technology
Quantification techniquesMeRIP-qPCR, MeRIP-RT-PCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1053 Transcriptome-wide map of mA circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension. Hua Su BMC Genomics [details] 31931709 10.1186/s12864-020-6462-y

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca