Summary:

NameIschemic Heart disease (A:m6A)
DescriptionMETTl3 is upregulated in H/R-induced cardiomyocytes injury. It methylates TFEB at two m6A residues in the 3ʹ-UTR, and promotes the association of the RNA-binding protein HNRNPD with TFEB pre-mRNA and subsequently decreases the expression levels of TFEB. This inhibits the autophagic flux and increases apoptosis in H/R-treated cardiomyocytes.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptTFEB
Mapping Technology
Quantification techniquesm6A dot blot assay, Me-RIP-RT-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1059 METTL3 and ALKBH5 oppositely regulate mA modification of mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes. Huiwen Song Autophagy [details] 30870073 10.1080/15548627.2019.1586246

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