|Ischemic Heart disease (A:m6A)
|METTl3 is upregulated in H/R-induced cardiomyocytes injury. It methylates TFEB at two m6A residues in the 3ʹ-UTR, and promotes the association of the RNA-binding protein HNRNPD with TFEB pre-mRNA and subsequently decreases the expression levels of TFEB. This inhibits the autophagic flux and increases apoptosis in H/R-treated cardiomyocytes.
|Related RNA reaction
|Found in RNA
|m6A dot blot assay, Me-RIP-RT-qPCR