Summary:

NameMalignant pleural mesothelioma (A:m6A)
DescriptionThe association between MPM and asbestos exposure is established but the mechanism is unclear. It was proposed that asbestos causes DNA damage by inducing DNA alkylation and methylation. Thus, methylation could be at the bases of the MPM onset and the characterized FTO rs9939609 polymorphism which alters its expression level, may play a role in asbestos-induced methylation and carcinogenesis
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptNone
Mapping TechnologyNone
Quantification techniquesNone

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO None Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1074 The Association Between the FTO rs9939609 Variant and Malignant Pleural Mesothelioma Risk: A Case-Control Study. Mina S Khella Genet Test Mol Biomarkers [details] 29260910 10.1089/gtmb.2017.0146

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca