| Description | The increased m6A methylation level, in melanoma-promoting genes, PD-1 (PDCD1), CXCR4, and SOX10, promotes melanoma cells proliferation, migration and invasion in vitro and melanoma tumor growth in vivo. FTO was found to be upregulated in melanoma, suggesting a protumorigenic role. FTO higher expression is induced by metabolic stress and starvation. It was found that PD-1 (PDCD1), CXCR4, and SOX10 are regulated by FTO-mediated demethylation which blocks the YTHDF2-induced mRNA decay (tumor suppressor). Furthermore, FTO-mediated demethylation plays an important role in therapeutic resistance to anti-PD-1 immunotherapy and cell killing by IFNγ |