Summary:

NameMelanoma (A:m6A)
DescriptionThe increased m6A methylation level, in melanoma-promoting genes, PD-1 (PDCD1), CXCR4, and SOX10, promotes melanoma cells proliferation, migration and invasion in vitro and melanoma tumor growth in vivo. FTO was found to be upregulated in melanoma, suggesting a protumorigenic role. FTO higher expression is induced by metabolic stress and starvation. It was found that PD-1 (PDCD1), CXCR4, and SOX10 are regulated by FTO-mediated demethylation which blocks the YTHDF2-induced mRNA decay (tumor suppressor). Furthermore, FTO-mediated demethylation plays an important role in therapeutic resistance to anti-PD-1 immunotherapy and cell killing by IFNγ
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptPD-1 (PDCD1), CXCR4, and SOX10
Mapping TechnologyMeRIP-seq
Quantification techniquesm6A dot blot assay, MeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1075 mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Seungwon Yang Nat Commun [details] 31239444 10.1038/s41467-019-10669-0

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