Myoclonus epilepsy, ragged-red fibers (MERRF) (A:m1A) - disease summary
Myoclonus epilepsy, ragged-red fibers (MERRF) (A:m1A)
Missing m1A modification on mitochondrial tRNA at the 58 position is associated with the MERRF disease. m1A58 provides a positive charge on tRNA tertiary structure that affect the binding of elongation factor which delivers tRNA to ribosome.
Related RNA reaction
Found in RNA
DM-tRNA-seq , tRNA-seq
Enzymes connected to this disease:
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
RNA modification landscape of the human mitochondrial tRNA regulates protein synthesis.
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