|Neuro-developmental disorder (C:m5C)
|Loss of m5C causes the accumulation of tRNA fragments in the absence of NSUN2. Therefore, reduction in protein translation rates and activation in stress pathways leading to reduced cell size and increased apoptosis of cortical, hippocampal, and striatal neurons occurred.
|Related RNA reaction
|Found in RNA
|NOP2/Sun RNA methyltransferase 2
|Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.