Summary:

NameNon-small cell lung cancer (A:m6A)
DescriptionMETTL3 promotes the translation of oncogenes such as EGFR and TAZ independently from its catalytic activity and m6A readers. The expression of these oncogenes mediates NSCLC cells growth, survival and invasion. METTL3 upregulation is reached by the downregulaion of miR-33a in NSCLC cells which normally reduces the expression of METTL3 by targeting its 3'UTR region.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptEGFR, TAZ
Mapping TechnologyMeRIP-seq
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1086 The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Lin S Mol Cell [details] 27117702 S1097-2765(16)30004-1
1087 MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. Du M Biochem Biophys Res Commun [details] 27856248 S0006-291X(16)31933-7

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