| Name | Non-small cell lung cancer (A:m6A) |
| Description | METTL3 promotes the translation of oncogenes such as EGFR and TAZ independently from its catalytic activity and m6A readers. The expression of these oncogenes mediates NSCLC cells growth, survival and invasion. METTL3 upregulation is reached by the downregulaion of miR-33a in NSCLC cells which normally reduces the expression of METTL3 by targeting its 3'UTR region. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | EGFR, TAZ |
| Mapping Technology | MeRIP-seq |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1086 | The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. | Lin S | Mol Cell | [details] | 27117702 | S1097-2765(16)30004-1 |
| 1087 | MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. | Du M | Biochem Biophys Res Commun | [details] | 27856248 | S0006-291X(16)31933-7 |