| Name | Osteoporosis (A:m6A) |
| Description | Decreased m6A level in bone marrow mesenchymal stem cells (MSCs) induces pathological features of osteoporosis in mice (impaired bone formation, incompetent osteogenic differentiation potential, and increased marrow adiposity). PTH (parathyroid hormone)/Pth1r (parathyroid hormone receptor-1) signaling axis is an important downstream pathway for m6A regulation in MSCs. METTL3 loss of function reduces the translation efficiency of MSCs lineage allocator Pth1r and disrupts the PTH-induced osteogenic and adipogenic responses in vivo. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | Pth1r |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | qRT-PCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | None | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1100 | Mettl3-mediated mA RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. | Liang Xie,Mengyuan Wang,Qiuchan Xiong,Yuchen Guo,Yu Liang,Jing Li,Rui Sheng,Peng Deng,Yuan Wang,Rixin Zheng,Yizhou Jiang,Ling Ye,Qianming Chen,Xuedong Zhou,Shuibin Lin, | Nat Commun | [details] | 30429466 | 10.1038/s41467-018-06898-4 |