| Name | Osteosarcoma (A:m6A) |
| Description | Expression level of METTL3 are up-regulated in human OS tissues and OS cell lines. METTL3 promotes osteosarcoma cell progression by regulating the m6A level of LEF1 and activating Wnt/b-catenin signaling pathway. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | LEF1 |
| Mapping Technology | |
| Quantification techniques | MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1101 | The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating them6A level of LEF1. | Miao W, Chen J, Jia L, Ma J, Song D | Biochem Biophys Res Commun | [details] | 31253399 | 10.1016/j.bbrc.2019.06.128 |