Summary:

NameParkinson (A:m6A)
DescriptionThe overexpression of FTO reduces m6A levels and increases NMDAR1 expression levels, NMDAR1, which could elevate oxidative stress and Ca2+. High expression of NMDAR1 will damage neurons and cause subsequent apoptotic death
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptNMDAR1
Mapping Technology
Quantification techniquesm6A dot blot assay

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1108 Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. Xuechai Chen ACS Chem Neurosci [details] 30835997 10.1021/acschemneuro.8b00657

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