Modomics - A Database of RNA Modifications

Summary:

NameType 2 Diabetes (A:m6A)
DescriptionAssociations between the FTO SNPs and type 2 diabetes,  further investigation is needed to identify the causal genetic variants and potential mechanisms underlying the observed genetic associations
Related RNA reactionA:m6A
Modified TranscriptNone
Mapping TechnologyNone
Quantification techniquesNone

Enzymes connected to Type 2 Diabetes:

Acronym Full name Enzyme Role Organism Comment
FTO Alpha-ketoglutarate-dependent dioxygenase FTO None Homo sapiens

Publications:

ID Title Authors Journal Details PubMed Id DOI
1123 A common variant in the FTO gene is associated with body mass index and predisposesto childhood and adult obesity. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI Science [details] 17434869 1141634