Summary:

NameBladder cancer (A:m6A)
DescriptionMETTL3 is upregulated in bladder cancer and m6A level is thus increased. AF4/FMR2 family member 4 (AFF4), two key regulators of NF-κB pathway (IKBKB and RELA) and MYC were further identified as direct targets of METTL3-mediated m6A modification
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptAFF4/NF-κB/MYC signaling axis
Mapping TechnologyMeRIP-seq
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
974 The mA methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network. Maosheng Cheng Oncogene [details] 30659266 10.1038/s41388-019-0683-z

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