Summary:

NameCervical cancer (A:m6A)
DescriptionFTO is frequently overexpressed in human cervical cancer tissues and highly correlated with cervical cancer progression.Mechanistically, FTO directly interacted with E2F1 and Myc mRNAs and inhibition FTO dramatically impaired the translation of these two important oncogenes, thus suppressed cervical cancer cells’ proliferation and migration.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptMYC, E2F1
Mapping Technology
Quantification techniquesm6A dot blot assay

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
994 The mA eraser FTO facilitates proliferation and migration of human cervical cancer cells. Dongling Zou Cancer Cell Int [details] 31827395 10.1186/s12935-019-1045-1

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