| Name | Colorectal cancer (A:m6A) |
| Description | The increased m6A methylation level (by METTL3) induces a RP11 accumulation in the nucleus and on chromatin. RP11 increased expression downregulates Siah1 and Fbxo45 and mediates the RP11-induced stabilization of Zeb1 which is fondamental to trigger CRC cells migration, invasion and EMT both in vitro and in vivo. |
| Related RNA reaction | A:m6A |
| Found in RNA | lncRNA |
| Modified Transcript | RP11 |
| Mapping Technology | |
| Quantification techniques | MeRIP-RT-PCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1003 | mA-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1. | Yingmin Wu | Mol Cancer | [details] | 30979372 | 10.1186/s12943-019-1014-2 |