| Name | Colorectal cancer (A:m6A) |
| Description | METTL3 is upregulated in colorectal cancer. METTL3 can methylate pri-miR-1246, which further promotes the maturation of pri-miR-1246. The anti-oncogene SPRED2 was identified as the downstream target of miR-1246, wherein downregulated SPRED2 further reverses the inhibition of the MAPK pathway. The METTL3/miR-1246/SPRED2 axis plays an important role in tumor metastasis and provides a new m6A modification pattern in CRC development. |
| Related RNA reaction | A:m6A |
| Found in RNA | miRNA |
| Modified Transcript | pri-miR-1246 |
| Mapping Technology | |
| Quantification techniques | m6A dot blot assay, MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1004 | Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway. | Jie Li,Ranran Chen,Qiou Gu,Peng Yang,Wenwei Qian,Dongjian Ji,Qingyuan Wang,Zhiyuan Zhang,Junwei Tang, | J Exp Clin Cancer Res | [details] | 31492150 | 10.1186/s13046-019-1408-4 |