Summary:

NameColorectal cancer (A:m6A)
DescriptionMETTL3 is upregulated in colorectal cancer. METTL3 can methylate pri-miR-1246, which further promotes the maturation of pri-miR-1246. The anti-oncogene SPRED2 was identified as the downstream target of miR-1246, wherein downregulated SPRED2 further reverses the inhibition of the MAPK pathway. The METTL3/miR-1246/SPRED2 axis plays an important role in tumor metastasis and provides a new m6A modification pattern in CRC development.
Related RNA reactionA:m6A
Found in RNAmiRNA
Modified Transcriptpri-miR-1246
Mapping Technology
Quantification techniquesm6A dot blot assay, MeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1004 Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway. Wen Peng J Exp Clin Cancer Res [details] 31492150 10.1186/s13046-019-1408-4

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