| Name | Gastric cancer (A:m6A) |
| Description | Increased m6A methylation level was found to be correlated with the upregulation of METTL3 in GC patients. The increased methylation influences cell proliferation, migration and invasion by regulting transcription factors like GFI-1, apoptotic-related protein expression, AKT signaling pathway (p-AKT, p70S6K and Cyclin D1). |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | AKT pathway , α‐smooth muscle actin (α‐SMA), GFI-1 |
| Mapping Technology | |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1383 | METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells | S Lin | Open Med (Wars) | [details] | 30886897 | - |
| 1384 | Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. | Tong Liu | J Cell Physiol | [details] | 31232471 | - |