Summary:

NameGastric cancer (A:m6A)
DescriptionIncreased m6A methylation level was found to be correlated with the upregulation of METTL3 in GC patients. The increased methylation influences cell proliferation, migration and invasion by regulting transcription factors like GFI-1, apoptotic-related protein expression, AKT signaling pathway (p-AKT, p70S6K and Cyclin D1).
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptAKT pathway , α‐smooth muscle actin (α‐SMA), GFI-1
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1383 METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells S Lin Open Med (Wars) [details] 30886897 -
1384 Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. Tong Liu J Cell Physiol [details] 31232471 -

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