Modomics - A Database of RNA Modifications


NameGastric cancer (A:m6A)
DescriptionDecreased m6A methylation level, by METTL14 downregulation or FTO upregulation, promotes the activation of oncogenic signaling pathways, such as Wnt and PI3K‐Akt and supports GC cell proliferation, migration and invasion.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptWnt and PI3K‐Akt pathways and E-chaderin
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1023 Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer. Cheng Zhang Cancer Med [details] 31243897 10.1002/cam4.2360

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