Summary:

NameGlioblastoma (A:m6A)
Descriptionm6A methylation protects against GSCs growth and self-renewal. FTO induced demethylation regulates GSCs growth and self-renewal, promotes tumor progression and shortens the lifespan of GSC-grafted animals.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptADAM19
Mapping TechnologyMeRIP-seq
Quantification techniquesm6A dot blot assay

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1027 m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of GlioblastomaStem Cells. Cui Q Cell Rep [details] 28297667 S2211-1247(17)30274-7

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