Summary:

NameGlioblastoma (A:m6A)
DescriptionIncreased m6A methylation (mediated by METTL3) induces GSCs mantainance and radioresistence, regulation of alternative splicing events and stability, differential regulation of miRNA and lincRNA, and expression of direct and indirect targets in key glioblastoma-related oncogenic pathways ( NOTCH, NFkB, Wnt, c-Myc, and TGF-b)
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptNOTCH, NFkB, Wnt, c-Myc, and TGF-b
Mapping TechnologyMeRIP-seq
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1387 N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Abhirami Visvanathan Genes (Basel) [details] 30781903 -
1388 Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. A Visvanathan Oncogene [details] 28991227 -

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