| Name | Glioblastoma (A:m6A) |
| Description | Increased m6A methylation (mediated by METTL3) induces GSCs mantainance and radioresistence, regulation of alternative splicing events and stability, differential regulation of miRNA and lincRNA, and expression of direct and indirect targets in key glioblastoma-related oncogenic pathways ( NOTCH, NFkB, Wnt, c-Myc, and TGF-b) |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | NOTCH, NFkB, Wnt, c-Myc, and TGF-b |
| Mapping Technology | MeRIP-seq |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1387 | N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. | Abhirami Visvanathan | Genes (Basel) | [details] | 30781903 | - |
| 1388 | Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. | A Visvanathan | Oncogene | [details] | 28991227 | - |